Platelet‐Derived Growth Factor‐BB Release Profile in Gingival Crevicular Fluid After Use of Marginal Periosteal Pedicle Graft as an Autogenous Guided Tissue Membrane to Treat Localized Intrabony Defects

Abstract

Periosteal coverage of periodontal defects is not associated with a significant increase in PDGF-BB levels.

Crevicular Fluid Growth Factors Release Profile Following the Use of Platelet‐Rich Fibrin and Plasma Rich Growth Factors in Treating Periodontal Intrabony Defects: A Randomized Clinical Trial

“…Growth factor levels decreased gradually in the three groups during different observation periods with no significant differences. This finding runs parallel with those of other studies that reported high levels of growth factors following initial stages of tissue injury 28–31 . The washing action of GCF appeared to dilute the claimed high levels of GF contained within platelet concentrate membranes.…”

Gingival crevicular fluid vascular endothelial cell growth factor and platelet‐derived growth factor‐BB release profile following the use of perforated barrier membranes during treatment of intrabony defects: a randomized clinical trial

“…To the authors’ knowledge, this study is the first to investigate these GF levels in the gingival crevicular fluid following PM coverage of intrabony defects. For optimal regeneration, physiologic GF levels should not be interrupted during the initial stages of healing or during remodeling stages . It was found that application of neutralizing VEGF‐A antibodies that disturb VEGF levels caused a striking reduction in wound angiogenesis, fluid accumulation and granulation tissue formation in a pig wound model .…”

Guided tissue regeneration of intrabony defects with perforated barrier membranes, simvastatin, and EDTA root surface modification: A clinical and biochemical study

“…Regenerative periodontal therapy uses specific techniques designed to restore those parts of the tooth‐supporting structures that have been lost as a result of periodontitis . One of the most important factors that could limit the outcomes of guided tissue membranes (GTR) as one of the main regenerative materials used in treatment of intrabony defects is the gingival vasculature, fibroblasts, stem cells, and periosteal isolation . During a GTR procedure, the periosteum is elevated with the flap, and occlusive guided tissue membranes are placed over the defect, thereby excluding any contribution of gingival cells and osteoblasts from the periosteum.…”

“…1 One of the most important factors that could limit the outcomes of guided tissue membranes (GTR) as one of the main regenerative materials used in treatment of intrabony defects is the gingival vasculature, fibroblasts, stem cells, and periosteal isolation. 2,3 During a GTR procedure, the periosteum is elevated with the flap, and occlusive guided tissue membranes are placed over the defect, thereby excluding any contribution of gingival cells and osteoblasts from the periosteum. This actually deprives the wound from a huge regenerative power of the gingiva and the periosteum, limiting the number of progenitor cells and biologic mediators required to repopulate periodontal defects.…”