Gingival crevicular fluid vascular endothelial cell growth factor and platelet‐derived growth factor‐<scp>BB</scp> release profile following the use of perforated barrier membranes during treatment of intrabony defects: a randomized clinical trial

Gamal, Ahmed; Abdel-Ghaffar, Khaled; Iacono, Vincent J.

doi:10.1111/jre.12321

Cited by 29 publications

(52 citation statements)

References 45 publications

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“…Such increase in the growth factors (GFs) levels could be considered an indirect factor for increased gingival fibroblast and GMSCs transmigration to the defect area through the membrane perforations which in turn enhance the periodontal tissue regeneration. This is in agreement with Gamal et al [25,31] who reported that the use ofMPM was associated with significantly higher gingival crevicular levels of bone morphogenic protein (BMP), patelate-derived growth factor(PDGF-BB) and vascular endothelial growth factor (VEGF).…”

Section: Discussionsupporting

confidence: 81%

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Quantitative Analysis of Interradicular Bone Regeneration after Use of Modified Perforated Collagen Membrane versus Occlusive Membrane in the Management of Grade II Furcation Defects in Dogs

2016

IJSR

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Aim of the work:the aim of this study is to find out the changes in the percentage of the bone surface area in the regenerating interradicular bone which take place in association with using occlusive or modified perforated collagen membranes in management of grade II furcation defects in dogs. Materials and Methods: A total number of four adult clinically healthy mongrel dogs were included in the current study. Sixteen grade II critical-sized furcation defects were surgically createdin lower premolars. In all four dogs, defects on the right quadrants were managed by ß-Tricalcium phosphate (ß-TCP) bone graft and occlusive collagen membrane and defects on the left quadrants were managed by ß-TCP bone graft and modified perforated collagen membrane. Results and conclusions: The obtained data revealed that modified perforated membrane had a positive better role in the regenerating of interradicular bone as revealed by significantly greater value of mean percentage of bone surface area which has taken place in association with it. (P < 0.05)

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Section: Discussionsupporting

confidence: 81%

“…Perforated barrier membranes were reported to open channels that allow for gingival stem cells and periosteal cells to take part in the regeneration. [15]Also they permit the growth and differentiation factors to pass from cells in the periosteum and gingival CT and augment regeneration [25].…”

Section: Discussionmentioning

confidence: 99%

Quantitative Analysis of Interradicular Bone Regeneration after Use of Modified Perforated Collagen Membrane versus Occlusive Membrane in the Management of Grade II Furcation Defects in Dogs

2016

IJSR

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“…However, in our study, xenogenic DBBA was added to maintain the volume of the filled defects. In further investigations, MPM coverage of periodontal defects was associated with a significant increase of BMP2 concentration and growth factor upregulation (vascular endothelial growth factor VEGF, platelet-derived growth factor-BB PDGF-BB) in gingival crevicular fluid during the early postoperative period [35,36].…”

Section: Discussionmentioning

confidence: 90%

Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: a 12-month randomized controlled trial

et al. 2018

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Objective The aim of this study was to compare the clinical and radiographic efficacy of guided tissue regeneration with a modified perforated collagen membrane (MPM) or standard collagen membrane (CM) in the treatment of intrabony defects in patients with aggressive periodontitis (AgP). Materials and methods Fifteen AgP patients were included in the study. Two single intrabony defects of at least 3 mm depth with ≥ 6 mm probing pocket depth (PPD) from each patient were randomly assigned to either xenogenic graft plus MPM (test group) or xenogenic graft plus CM (control group). PPD, clinical attachment level (CAL), and gingival recession (GR) were recorded at baseline and at 12 months. The radiographic assessments included the measurements of defect depth (DD), change in alveolar crest position (ACP), linear defect fill (LDF), and percentage defect fill (%DF). Results After treatment, PPD, CAL, DD, and ACP values improved significantly in both groups, without statistical differences between them. However, with respect to LDF and %DF, the 12-month radiographic analysis at MPM-treated sites showed a significant improvement compared to the 6-month outcomes, that was not observed at control sites (additional LDF of 0.4 ± 0.5 mm, p = 0.010 and %DF of 6.4 ± 7.6%, p = 0.025). Conclusions Both strategies proved effective in the treatment of intrabony defects in patients with AgP. Nonetheless, enhanced LDF and %DF 12 months postoperatively at MPM-treated sites may stem from cellular and molecular migration from the periosteum and overlying gingival connective tissue through barrier's pores. Clinical relevance Modification of CM may have positive ramifications on periodontal regeneration.

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“…GCF flow, with its physical protective effects of flushing the pocket, is considered an excellent undispersed media for evaluating released growth factors from platelet concentrate products at different time periods 26 . The selection of intrabony defect type is another factor that helps in maintaining PDGF‐BB or VEGF for accurate evaluation of its availability and release pattern.…”

Section: Discussionmentioning

confidence: 99%

Crevicular Fluid Growth Factors Release Profile Following the Use of Platelet‐Rich Fibrin and Plasma Rich Growth Factors in Treating Periodontal Intrabony Defects: A Randomized Clinical Trial

Gamal

Abdel-Ghaffar

Alghezwy

2016

Journal of Periodontology

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Gingival crevicular fluid vascular endothelial cell growth factor and platelet‐derived growth factor‐BB release profile following the use of perforated barrier membranes during treatment of intrabony defects: a randomized clinical trial

Abstract: Within the limits of the present study, one can conclude that PM coverage of periodontal defects is associated with initial gingival crevicular fluid growth factor upregulation that could improve the clinical outcomes of guided tissue regeneration surgery.

Cited by 29 publications

References 45 publications

Quantitative Analysis of Interradicular Bone Regeneration after Use of Modified Perforated Collagen Membrane versus Occlusive Membrane in the Management of Grade II Furcation Defects in Dogs

Quantitative Analysis of Interradicular Bone Regeneration after Use of Modified Perforated Collagen Membrane versus Occlusive Membrane in the Management of Grade II Furcation Defects in Dogs

Treatment of intrabony defects with modified perforated membranes in aggressive periodontitis: a 12-month randomized controlled trial

Crevicular Fluid Growth Factors Release Profile Following the Use of Platelet‐Rich Fibrin and Plasma Rich Growth Factors in Treating Periodontal Intrabony Defects: A Randomized Clinical Trial

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