Platelet-derived chemokines in inflammation and atherosclerosis

Bakogiannis, Constantinos; Sachse, Marco; Stamatelopoulos, Kimon; Stellos, Konstantinos

doi:10.1016/j.cyto.2017.09.013

Cited by 182 publications

(147 citation statements)

References 115 publications

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“…The atherothrombotic process underlies acute coronary and cerebrovascular events where the activation of inflammatory mechanisms is strictly dependent on interaction among different cell types, such as platelets, leukocytes, and cells of the vascular wall. As extensively reviewed [29][30][31], once adhered to the damaged vessel wall platelets participate in multiple mechanisms promoting thromboinflammation by releasing storage granules and aggregating to form thrombi. As mentioned, platelet adhesion is influenced by adhesion molecules present in the subendothelial matrix components, such as E-selectin [32], vWF [33], collagen, fibronectin, and by the level of shear stress in the circulation [34].…”

Section: Platelets In Hemostasis and Thrombosismentioning

confidence: 99%

Influence of Cardiometabolic Risk Factors on Platelet Function

Barale

Russo

2020

IJMS

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Platelets are key players in the thrombotic processes. The alterations of platelet function due to the occurrence of metabolic disorders contribute to an increased trend to thrombus formation and arterial occlusion, thus playing a major role in the increased risk of atherothrombotic events in patients with cardiometabolic risk factors. Several lines of evidence strongly correlate metabolic disorders such as obesity, a classical condition of insulin resistance, dyslipidemia, and impaired glucose homeostasis with cardiovascular diseases. The presence of these clinical features together with hypertension and disturbed microhemorrheology are responsible for the prothrombotic tendency due, at least partially, to platelet hyperaggregability and hyperactivation. A number of clinical platelet markers are elevated in obese and type 2 diabetes (T2DM) patients, including the mean platelet volume, circulating levels of platelet microparticles, oxidation products, platelet-derived soluble P-selectin and CD40L, thus contributing to an intersection between obesity, inflammation, and thrombosis. In subjects with insulin resistance and T2DM some defects depend on a reduced sensitivity to mediators-such as nitric oxide and prostacyclin-playing a physiological role in the control of platelet aggregability. Furthermore, other alterations occur only in relation to hyperglycemia. In this review, the main cardiometabolic risk factors, all components of metabolic syndrome involved in the prothrombotic tendency, will be taken into account considering some of the mechanisms involved in the alterations of platelet function resulting in platelet hyperactivation.

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Section: Platelets In Hemostasis and Thrombosismentioning

confidence: 99%

Influence of Cardiometabolic Risk Factors on Platelet Function

Barale

Russo

2020

IJMS

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“…Circulatory neutrophils and lymphocytes may have different key roles in the pathophysiologic development of atherosclerosis through their respective secretory [34]. In atherosclerotic plaques at each stage, a certain number of neutrophils are usually observed to accumulate on the vascular wall, triggering inflammatory reactions by releasing active molecules, such as proinflammatory cytokines and oxyradical, and may lead to endothelial dysfunction and the formation of atherosclerosis by reducing the utilization of nitrogen oxide [35].…”

Section: Tablementioning

confidence: 99%

Neutrophils and neutrophil-lymphocyte ratio: Inflammatory markers associated with intimal-media thickness of atherosclerosis

Meng

Guo

et al. 2018

Thrombosis Research

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Based on χ, Spearman's rho test and multiple linear regression, NEU is related with intimal thickness (P < 0.05). Furthermore, NEU can predict the intimal thickness through the ROC curve. What's more, N/L is a risk factor of carotid media thickness (P < 0.05) by the Spearman's rho test, and is also correlated with poor NDT (P < 0.05) based on univariate Cox proportional regression analysis. Through ROC curve, N/L can predict the carotid media thickness. The carotid atherosclerotic endarterium is richest in macrophagocytes, and the arrangement of endotheliocytes is disordered. In summary, the increased NEU and N/L respectively have a strong correlation and precise predictability for carotid intimal and media thickness of atherosclerosis.

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“…Blood platelets and chemokines constitute particularly significant factors in the process of atherosclerosis. CXCL4 (also known as blood platelet factor 4) is one of the platelet chemokines which is most abundantly secreted to plasma (in micromolar concentrations) after the activation of blood platelets [6,7]. CXCL4 supports the differentiation of monocytes into macrophages and decreases the expression of CD163 receptor indicating protective action against atherosclerosis and significantly contributing to elimination of haemoglobin and haptoglobin complexes [8,9].…”

Section: Introductionmentioning

confidence: 99%

DASH diet decreases CXCL4 plasma concentration in patients diagnosed with coronary atherosclerotic lesions

Makarewicz‐Wujec

Henzel

Kruk

et al. 2020

Nutrition, Metabolism and Cardiovascular Diseases

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Background and aims: Aim of this study involved assessment of the intensive intervention concerning lifestyle based on the DASH diet model on plasma concentration of CXCL4 chemokine among patients with coronary atherosclerosis. Methods and results: The Dietary Intervention to Stop Coronary Atherosclerosis in Computed Tomography Study randomized patients with stable CAD to an interventional group (n Z 41), where DASH diet was implemented and the control group (n Z 40) without dietary intervention.Dietary counselling was provided to DASH group during all 6 control visits within 6 months of observation. During the study, body weight and body composition were controlled using the bioimpedance method. CXCL4 concentration was determined with the use of ELISA test.Within the DASH group, a significant decrease in body weight, a decrease in high sensitivity Creactive protein concentration (À0.32 AE 2.8 mg/l; p < 0.05), as well as a decrease in CXCL4 concentration (À3.35 AE 3.4 ng/ml; p < 0.0001) were observed. Occurring changes were not statistically significant within the control group. Conclusions: DASH diet lessens CXCL4 concentration among patients with a stable CAD, however, further research is necessary in order to confirm aforementioned results and evaluate the impact on atherosclerotic plaque. This trial was registered at: www.clinicaltrials.gov as NCT02571803.

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Platelet-derived chemokines in inflammation and atherosclerosis

Cited by 182 publications

References 115 publications

Influence of Cardiometabolic Risk Factors on Platelet Function

Influence of Cardiometabolic Risk Factors on Platelet Function

Neutrophils and neutrophil-lymphocyte ratio: Inflammatory markers associated with intimal-media thickness of atherosclerosis

DASH diet decreases CXCL4 plasma concentration in patients diagnosed with coronary atherosclerotic lesions

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