DASH diet decreases CXCL4 plasma concentration in patients diagnosed with coronary atherosclerotic lesions

Abstract

Background and aims: Aim of this study involved assessment of the intensive intervention concerning lifestyle based on the DASH diet model on plasma concentration of CXCL4 chemokine among patients with coronary atherosclerosis. Methods and results: The Dietary Intervention to Stop Coronary Atherosclerosis in Computed Tomography Study randomized patients with stable CAD to an interventional group (n Z 41), where DASH diet was implemented and the control group (n Z 40) without dietary intervention.Dietary counselling was provided to DASH group during all 6 control visits within 6 months of observation. During the study, body weight and body composition were controlled using the bioimpedance method. CXCL4 concentration was determined with the use of ELISA test.Within the DASH group, a significant decrease in body weight, a decrease in high sensitivity Creactive protein concentration (À0.32 AE 2.8 mg/l; p < 0.05), as well as a decrease in CXCL4 concentration (À3.35 AE 3.4 ng/ml; p < 0.0001) were observed. Occurring changes were not statistically significant within the control group. Conclusions: DASH diet lessens CXCL4 concentration among patients with a stable CAD, however, further research is necessary in order to confirm aforementioned results and evaluate the impact on atherosclerotic plaque. This trial was registered at: www.clinicaltrials.gov as NCT02571803.

The Effect of Intensive Dietary Intervention on the Level of RANTES and CXCL4 Chemokines in Patients with Non-Obstructive Coronary Artery Disease: A Randomised Study

“…Contrarily, in the control group, there was a significant increase in the CXCL4 level by 18.8% in the last 6 months of the observation. As reported previously, the increase in the CXCL4 level in the first half of the study in the control group was only insignificant [34].…”

Effects of Dietary Patterns on Biomarkers of Inflammation and Immune Responses: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…Nineteen studies included both sexes, with prevailing proportions of participating women than men (28, 29, 31, 33-36, 38-46, 49, 50), whereas 4 studies included only women (32,37,48) or men (30), respectively. With regards to prevalent diseases, 3 studies included adults with cardiovascular disease (28,33,34), whereas 11 studies included adults characterized by existing cardiovascular disease risk factors (including obesity and type 2 diabetes) (31,32,36,37,39,(43)(44)(45)50). Within all studies included in the meta-analysis, 4 included older participants (aged >55 y) (38,40,42,46) among which 2 studies included only healthy participants (38,40) and the other 2 included older adults with a high risk of cardiovascular disease (42,46).…”

“…Duration of interventions ranged from 4 wk to 5 y (28-50). Among the dietary patterns assessed, the Mediterranean diet was the most investigated diet (n = 16) (30-33, 35-44, 46, 47), followed by the Dietary Adherence to Stop Hypertension (DASH) diet (n = 4) (28,29,45,48). Other studies assessed a vegan diet (n = 1) (34), a vegetarian diet (n = 1) (29), the New Nordic Diet (n = 1) (49), and the Nordic prudent diet (n = 1) (50) collectively categorized as "vegetarian/vegan diet" in the current metaanalysis.…”

Association Between Dietary Quality Indices and Atherosclerosis Risk: A Case-Control Study

“…Moreover, Magdalena et.al showed a decrease in hs-CRP levels, with concomitant reduction in CXCL4 concentration, which most probably was a result of a significant increase in the consumption of vegetables, indicated in the analysis results of correlation with DASH index for vegetable consumption. 29 Studies show that CXCL4 chemokine could induce differentiation of macrophages which constitute main cellular components of atherosclerotic plaque during its formation and progression. 30 The present study demonstrated that the control group had a higher score of the Mediterranean pattern.…”