Platelet Deposition on ePTFE Grafts Coated with Fibrin Glue with or without FGF-1 and Heparin

Zarge, Joseph I.; Gosselin, Claire; Huang, Peter; Greisler, Howard P.

doi:10.1006/jsre.1996.4903

Cited by 31 publications

(11 citation statements)

References 5 publications

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“…30 Successful use of this sealing technique using fibrin glue confirms the experimental feasibility reported in the 1980s. [9][10][11][12] Also in agreement with earlier experiments 31,32 is the finding that the immediate thrombogenicity of grafts sealed with the fibrin glue matrix was not greater than that of preclotted grafts.…”

Section: Discussionsupporting

confidence: 88%

Sealing of Polyester Prostheses with Autologous Fibrin Glue and Bone Marrow

Cardon

Chakfé

Thaveau

et al. 2000

Annals of Vascular Surgery

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Section: Discussionsupporting

confidence: 88%

Sealing of Polyester Prostheses with Autologous Fibrin Glue and Bone Marrow

Cardon

Chakfé

Thaveau

et al. 2000

Annals of Vascular Surgery

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“…In the 1990s, fibrin matrix collected from the patient's plasma was used as a fibrin coating in the prosthetic vascular graft (9,19). Recent reports demonstrated that the fibrin coating in small caliber vascular prostheses decreased acute platelet deposition and prevented early thrombosis significantly (1,2).…”

Section: Discussionmentioning

confidence: 99%

“…Currently, fibrin coatings in small caliber vascular prostheses has been shown to decrease acute platelet deposition and to prevent early thrombus formation (1,2). It is generally believed that a fibrin can interact with tissues and blood without inducing inflammation or thrombosis because of its biocompatibility (3).…”

mentioning

confidence: 99%

Thrombin‐free Fibrin Coating on Small Caliber Vascular Prostheses Has High Antithrombogenicity in Rabbit Model

et al. 2005

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Fibrin coatings on prosthetic vascular graft, which are conventionally produced by fibrinogen and thrombin, are expected to improve antithrombogenicity and healing characteristics. Thrombin is one of the factors of blood coagulation cascade; however, it has a possibility to play a negative role in the graft antithrombogenicity. The purpose of this study was to evaluate the performance of our new grafts, thrombin-free fibrin-coated small caliber vascular prostheses. Knitted polyester fabric vascular prostheses 2 mm in internal diameter were coated with fibrin coating with thrombin (Graft I) or without thrombin (Graft II). Both grafts were implanted in bilateral common carotid arteries of 35 Japanese white rabbits, with Graft I in one side and Graft II in the contralateral side. Graft patency, histology, thrombin activity, and platelet deposition were compared between both grafts on postoperative days (PODs) 1, 3, 7, 10, 14, 30, and 60. Both grafts were patent without thrombus or stenosis at each end point (maximal period, POD 60). Macro- and microscopic findings revealed that no obvious difference was observed between both grafts. Before graft implantation, thrombin activities in Grafts I and II were 0.711 +/- 0.086 and 0.009 +/- 0.007 optical density at 405 nm, respectively. Thrombin activity of Graft II was significantly less than that of Graft I in every period after graft implantation, and platelet deposition of Graft II was significantly less than that of Graft I until POD 30. Thrombin-free fibrin-coated vascular prostheses have superior performance of antithrombogenicity to conventional fibrin-coated vascular prostheses with thrombin.

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“…The second approach is to promote the binding of selected molecules chosen for their biological activity. These molecules can, for example, promote cell adhesion [fibronectin (FN), laminin, vitronectin, and RGDS peptide],12–17 migration and proliferation (VEGF, FGF)18–20 or inhibit coagulation (heparin, heparan sulfate) 21–23. Biomolecules are frequently used to modify the surface of biomaterials with the objective of improving their biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Covalent Grafting of Fibronectin onto Plasma‐Treated PTFE: Influence of the Conjugation Strategy on Fibronectin Biological Activity

Vallières

Petitclerc

Laroche

2007

Macromolecular Bioscience

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Surface coating of synthetic materials is often considered to improve biomedical devices biocompatibility. In this study, we covalently bound fibronectin (FN) onto ammonia plasma-treated PTFE via two crosslinkers, namely glutaric anhydride (GA) and sulfosuccinimidyl-4-(p-maleimidophenyl)butyrate (sulfo-SMPB). With respect to clean PTFE, cell adhesion increased markedly on both FN grafted surfaces, although it was twice higher on PTFE-GA-FN than on PTFE-SMPB-FN. ELISA experiments performed with a polyclonal antibody revealed that the amount of FN is identical on both surfaces while monoclonal antibody specific to the RGD binding site clearly demonstrated a greater availability when FN is surface grafted through GA. These results provide evidence of a variation in protein conformation correlated with the surface conjugation strategy.

show abstract

Platelet Deposition on ePTFE Grafts Coated with Fibrin Glue with or without FGF-1 and Heparin

Cited by 31 publications

References 5 publications

Sealing of Polyester Prostheses with Autologous Fibrin Glue and Bone Marrow

Sealing of Polyester Prostheses with Autologous Fibrin Glue and Bone Marrow

Thrombin‐free Fibrin Coating on Small Caliber Vascular Prostheses Has High Antithrombogenicity in Rabbit Model

Covalent Grafting of Fibronectin onto Plasma‐Treated PTFE: Influence of the Conjugation Strategy on Fibronectin Biological Activity

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