Platelet count and volume indices in patients with contrast-induced acute kidney injury and acute myocardial infarction treated invasively

Francuz, Paweł; Kowalczyk, Jacek; Swoboda, Ryszard; Przybylska-Siedlecka, Katarzyna; Kozieł, Monika; Podolecki, Tomasz; Świątkowski, Andrzej Marian; Lenarczyk, Radosław; Średniawa, Beata; Kalarus, Zbigniew

doi:10.5603/kp.a2015.0054

Cited by 4 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the one hand, higher platelet count was an independent risk factor for CIN in patients with diabetes or baseline kidney dysfunction. [31] On the other hand, in patients with non-ST-segment-elevation myocardial infarction (NSTEMI) after PCI, lymphocyte counts were significantly lower in the CIN group compared with the non-CIN group. [32] What is more, previous studies have shown that PLR is an independent predictor of CIN in ACS patients after PCI or angiography.…”

Section: Discussionmentioning

confidence: 99%

Could platelet-to-lymphocyte ratio be a predictor for contrast-induced nephropathy in patients with acute coronary syndrome?

Jiang¹,

Xie

et al. 2019

Medicine

View full text Add to dashboard Cite

Background: Contrast-induced nephropathy (CIN) is acute renal failure observed after administration of iodinated contrast media during angiographic or other medical procedures. In recent years, many studies have focused on biomarkers that recognize CIN and/or predict its development in advance. One of the many biomarkers studied is the platelet-to-lymphocyte ratio (PLR). We performed a systematic review and meta-analysis to evaluate the correlation between PLR level and CIN. Methods: Relevant studies were searched in PUBMED, EMBASE, and Web of Science until September 15, 2018. Case-control studies reporting admission PLR levels in CIN and non-CIN group in patients with acute coronary syndrome (ACS) were included. The pooled weighted mean difference (WMD) and 95% confidence intervals (95%CI) were calculated to assess the association between PLR level and CIN using a random-effect model. Results: Six relevant studies involving a total of 10452 ACS patients (9720 non-CIN controls and 732 CIN patients) met our inclusion criteria. A meta-analysis of 6 case-control studies showed that PLR levels were significantly higher in CIN group than those in non-CIN group (WMD = 33.343, 95%CI = 18.863 to 47.823, P < .001, I 2 = 88.0%). Conclusion: For patients with ACS after contrast administration, our meta-analysis shows that on-admission PLR levels in CIN group are significantly higher than those of non-CIN group. However, large and matched cohort studies are needed to validate these findings and assess whether there is a real connection or just an association.

show abstract

Section: Discussionmentioning

confidence: 99%

Could platelet-to-lymphocyte ratio be a predictor for contrast-induced nephropathy in patients with acute coronary syndrome?

Jiang¹,

Xie

et al. 2019

Medicine

View full text Add to dashboard Cite

show abstract

“…27 In the present study, the development of CIN was higher in female patients, smokers, patients with multi-vessel disease, low hct, low ejection fraction, high platelet count, low serum albumin, in line with the literature. [39][40][41][42][43] In addition to C-peptide, HbA1c and albumin were independent predictors of CIN development. The predictive value of HbA1c and albumin for the development of CIN has been shown in previous studies.…”

Section: Discussionmentioning

confidence: 99%

Effect of Serum C-Peptide Levels on the Development of Contrast-Induced Nephropathy in Diabetic Patients Undergoing Coronary Angiography

Toprak

2022

Angiology

View full text Add to dashboard Cite

Contrast-induced nephropathy (CIN) is an important cause of morbidity and mortality, in patients with diabetes who undergo coronary angiography (CAG). It is known that serum C-peptide has renoprotective effects in diabetic nephropathy. Patients with diabetes (n = 552) who underwent CAG in our center between January 2020 and December 2021 were included, retrospectively. The patients were divided into 2 groups: not-developing CIN (group 1) and developing CIN (group 2). CIN developed in 128 (23.1%) of the patients with diabetes who underwent CAG. C-peptide, albumin, hemoglobin, hematocrit, initial creatinine, ejection fraction (EF), were significantly lower in the group that developed CIN compared with the group that did not ( P < .05, for all). In correlation analysis, creatinine increase rate (ΔCr) was negatively correlated with C-peptide, hematocrit, and ejection fraction (r = −.241, P < .001; r = −.135, P < .001; r = −.194, P = .001; respectively). In logistic regression analysis, C-peptide level (Odds Ratio: .404, 95% Confidence Interval: .286-.571, P < .001) was an independent predictor of CIN. In the present study, C-peptide level was an independent predictor of CIN in patients with diabetes. This study suggests that low levels of C-peptide are associated with a greater risk of CIN.

show abstract

“…According to Han JS et al study, it was found that applying mean platelet volume is construed a dear but effective predictor for 28-day all-cause mortality for patients suffering from AKI who are in need of continuous renal replacement therapy (5). In the study of Francuz P et al, it was reported that AKI development was not related to platelet volume index; however, higher platelet count was an independent risk factor for AKI in patients with diabetes or baseline kidney dysfunction (8). According to a previous study, MPV declines in some diseases including reflux nephropathy, Crohn's disease, pulmonary tuberculosis, and chronic spontaneous urticaria (1,(9)(10)(11)(12).…”

Section: Discussionmentioning

confidence: 99%

Complete Blood Cell and HCO3 as a Predictor of Developing Acute Kidney Injury in Children

et al. 2016

View full text Add to dashboard Cite

Background: Acute kidney injury (AKI) due to hypovolemia and gastroenteritis is still a common disease, especially among children in developing countries. The risk, injury, failure, loss, and end-stage renal disease (RIFLE) classification is used as the estimated indicator of outcomes and incidence of AKI. Leukocytosis may be seen with systemic infectious, inflammatory diseases, and pyelonephritis. However, the cell blood count is unspecific. Some studies have shown the role of complete blood count in AKI as a useful predictive factor for mortality. We aimed at investigating cell blood count indexes and HCO3 in the prognosis of children with RIFLE criteria of AKI. Methods: In this prospective study, 206 patients with AKI, who were admitted to Amir-Kabir emergency department, were investigated. The complete blood count, erythrocyte sedimentation rate, serum HCO3, and electrolytes of the patients were measured and compared. All patients were followed monthly for 4 months for renal function test and clinical manifestation. Data analysis was performed by SPSS Version 18 (IBM Corp., NY, US.). Mean, standard deviation, standard error, and frequency were used for descriptive analysis; and t-test, Chi-square, Mann-Whitney and Friedman tests were used for data analysis. Results: There were no significant differences between the 4 groups in white blood cell count, hemoglobin, hematocrit, and ESR at baseline (P > 0.05). The number of platelet units was remarkably higher, but the number of MPV and HCO3 was considerably lower in patients with loss/ failure criteria. Conclusions: MPV is higher in the case of platelets destruction, and this is commonly observed in inflammatory diseases. Metabolic acidosis is related to AKI and may lead to disorders such as hypotension, cardiac dysfunction, and mortality. HCO3, and MPV are likely to act as a predictor of the development of AKI. Conducting a multicenter study with a larger sample size and longer follow-up is suggested to examine the predictive factor of AKI.

show abstract

Platelet count and volume indices in patients with contrast-induced acute kidney injury and acute myocardial infarction treated invasively

Abstract: Any similarities in the pathophysiology of CI-AKI and IR were not reflected in platelet parameters. CI-AKI development was not related to PVI; however, higher PC was an independent risk factor for CI-AKI in patients with diabetes or baseline kidney dysfunction.

Cited by 4 publications

References 0 publications

Could platelet-to-lymphocyte ratio be a predictor for contrast-induced nephropathy in patients with acute coronary syndrome?

Could platelet-to-lymphocyte ratio be a predictor for contrast-induced nephropathy in patients with acute coronary syndrome?

Effect of Serum C-Peptide Levels on the Development of Contrast-Induced Nephropathy in Diabetic Patients Undergoing Coronary Angiography

Complete Blood Cell and HCO3 as a Predictor of Developing Acute Kidney Injury in Children

Contact Info

Product

Resources

About