Platelet Aggregation Inhibitors from the Seeds ofSwietenia mahagoni: Inhibition ofin vitroandin vivoPlatelet-Activating Factor-Induced Effects of Tetranortriterpenoids Related to Swietenine and Swietenolide

Ekimoto, Hisao; Irie, Y; Araki, Y; Han, Gui-Qiu; Kadota, Shigetoshi; Kikuchi, Tohru

doi:10.1055/s-2006-960018

Cited by 33 publications

(23 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among them, several new compounds, named swietemahonins A, D, E, and G and 3-O-acetyl-swietenolide and 6-O-acetyl-swietenolide were identified. These compounds have been shown to strongly inhibit plateletactivating factor (PAF)-induced platelet aggregation [16] . In the seeds, two tetranotriterpenoids, mahonin ( Figure 4) and secomahoganin ( Figure 5), were isolated.…”

Section: Constituent Phytochemicalsmentioning

confidence: 99%

Pharmacological effects and active phytoconstituents of Swietenia mahagoni: a review

Naveen

Rupini

Ahmed

et al. 2014

Journal of Integrative Medicine

View full text Add to dashboard Cite

Section: Constituent Phytochemicalsmentioning

confidence: 99%

Pharmacological effects and active phytoconstituents of Swietenia mahagoni: a review

Naveen

Rupini

Ahmed

et al. 2014

Journal of Integrative Medicine

View full text Add to dashboard Cite

“…Ekimoto et al (1991) showed that several tetranotriterpenoids, isolated from Swietenia mahogany L. Jacq. (Meliaceae), strongly inhibited PAFinduced aggregation, while glycyrrhizin, an anti-inflammatory compound from Glycyrrhiza glabra Linne, has been identified as a new thrombin inhibitor (Franscichetti et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Antiplatelet Activity ofα.- andβ.-Amyrin, Isomeric Mixture fromProtium heptaphyllum.

Aragão

Carneiro

Júnior

et al. 2007

Pharmaceutical Biology

View full text Add to dashboard Cite

A mixture of triterpenes named a-and b-amyrin (AMI), isolated from the Brazilian medicinal herb Protium hetaphyllum (Aubl) March (Burseraceae), was evaluated for the ability to inhibit aggregation of human platelets induced by adenosine 5 0 -diphosphate (ADP, 1.5 and 3 mM), collagen, and arachidonic acid (AA) in vitro. The results showed that AMI significantly inhibited platelet aggregation (40, 64, and 60%) in the assay carried out with ADP (3 mM) as agonist, at the doses of 100, 150, and 200 mM, respectively. In the presence of a lower ADP concentration (1.5 mM), a 3-time higher percentage of inhibition (32%) was observed with AMI 50 mM, as compared to that seen with 3.0 mM ADP. In the test using collagen (10 mg=mL) as agonist, AMI (50, 100, and 150 mM) inhibited aggregation by 26, 47, and 39%, respectively, while in the presence of the arachidonic acid (150 mM) at the doses of 50, 100, 150, and 200 mM, it inhibited platelet aggregation by 20, 21, 25, and 27%, respectively. The lowest IC 50 value for the AMI inhibitory effect was observed with collagen (90.0 mM), followed by ADP (117.9 mM) and arachidonic acid (181.4 mM). With ADP as agonist, the anti-aggregant effect of the acetylsalicylic acid (ASA) was potentiated by AMI but not by dipyridamole. No potentiation was observed after the combination of ASA and AMI with collagen or arachidonic acid as agonists. Our results indicated that AMI possesses a platelet anti-aggregant activity in a concentration-dependent manner and probably acts on a biochemical pathway common to all the agonists tested.

show abstract

“…The platelet aggregation test described by Ekimoto et al (1991) was modified and performed with collagen (500 µg/mL) and ADP (0.05 µm) was used as an aggregation agent. A 0.2 mL aliquot of PRP to which was added a 10 µL aliquot of a test solution was placed in a test tube and stirred at 1200 rpm, at 37°C, for 1 min.…”

Section: Anti-endotoxin-induced Dic Effect In Normal Ratsmentioning

confidence: 99%

Effects of traditional herbal medicine, hwaotang, on atherosclerosis using the spontaneous familial hypercholesterolemia model, kurosawa and kusanagi-hypercholesterolemic rabbits and the venous thrombosis rats

et al. 2005

View full text Add to dashboard Cite

Hwaotang (HOT), a traditional Korean medicinal formulation, is a dried decoctum of a mixture of seven herbal medicines, consisting of Angelica gigantis Radix, Rehmanniae Radix, Paeoniae Radix, Ciniamomi Cortex, Cnidii Rhizoma, Persicae Semen and Carthami Flos. In the present study, the inhibitory effects and anti thrombic properties of HOT on the progression of atherosclerotic lesions were studied using the spontaneous familial hypercholesterolemia (FH) model, Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits and rats. Changes in blood chemistry, pathology and low-density lipoprotein (LDL) oxidation were measured in a control and HOT group. In the control group, the area of atheromatous plaques of the aorta progressed between week 12 (36.65%) and week 14 (46.22%). This progression of atherosclerotic lesions did not occur in the HOT-treated group after 12 (24.24%) and 14 (23.34%) weeks. Antioxidative effects on LDL were seen in the HOT in weeks 12 and 14. HOT improved the hypercholesterolemia in the KHC rabbits. On the other hand, HOT and five of the seven herbs, except Cnidii Rhizoma and Carthami Flos, inhibited the endotoxin-induced hepatic venous thrombosis in high cholesterol diet-treated rats. However, Ciniamomi Cortex showed a very weak inhibitory effect on the endotoxin-induced hepatic venous thrombosis. The extract also inhibited the endotoxin-induced decrease in blood platelets and fibrinogen, and endotoxin-induced increase in fibrin degradation products (FDP) on disseminated intravascular coagulation in normal rats. In conclusion, these results suggest that HOT has inhibitory effects on the development of atheromatous plaque formation in spontaneous FH rabbits. It is also suggested that the antioxidative effects of HOT on LDL led to the beneficial effects observed in this study. The protection by HOT and its herbs on the artificially induced ischemic infarction might be related to their inhibitory effects on disseminated intravascular coagulation, platelet coagulation and thrombotic action.

show abstract

Platelet Aggregation Inhibitors from the Seeds ofSwietenia mahagoni: Inhibition ofin vitroandin vivoPlatelet-Activating Factor-Induced Effects of Tetranortriterpenoids Related to Swietenine and Swietenolide

Cited by 33 publications

References 0 publications

Pharmacological effects and active phytoconstituents of Swietenia mahagoni: a review

Pharmacological effects and active phytoconstituents of Swietenia mahagoni: a review

Antiplatelet Activity ofα.- andβ.-Amyrin, Isomeric Mixture fromProtium heptaphyllum.

Effects of traditional herbal medicine, hwaotang, on atherosclerosis using the spontaneous familial hypercholesterolemia model, kurosawa and kusanagi-hypercholesterolemic rabbits and the venous thrombosis rats

Contact Info

Product

Resources

About