Platelet Aggregation Inhibitors and Inotropic Constituents in Pyrolae Herba.

In Vitro Study of the Anti-Inflammatory Activity of Some Medicinal and Edible Plants Growing in Russia

“…Two wintergreen compounds shown to be active in anti-inflammatory tests (carrageenan-induced hind paw edema in rats) and analgesic tests (acetic acid-induced writhing in mice) were identified as chimaphilin and ursolic acid [22]. The inotropic and platelet aggregation inhibitory activity of Pyrola plants has also been attributed to chimaphilin [23]. Clearly, chimaphilin plays an important role in the bioactivity of P. decorata and, possibly, in other plants of the Pyrolaceae family.…”

Phenolic Glycosides from Pyrola japonica

“…3,5,6,19) TLC analysis of the acid hydrolysates of 4, 5, 7, 8, and 10 indicated the presence of glucose in 4, 5, 7, and 8, and glucose and xylose in 10. The absolute configuration of the sugars was determined to be D by GC analysis of their thiazolidine derivatives.…”

“…Earlier investigations of Pyrola plants led to the isolation of ursolic acid, 3) an iridoid, 4) quinones, 5,6) flavonoids, 4,5,7) tetralones 5) and other phenolic glycosides. 4,[8][9][10][11][12] As part of our continuing search for anti-inflammatory agents from plants, [13][14][15][16] a BuOH extract of the whole plant of P. japonica was subjected to a chemical investigation leading to the isolation of twelve compounds, among which five were new.…”

“…The BuOH fraction from the MeOH extract of the whole plant of P. japonica yielded 5 new compounds (4, 5, 7, 8, 10) upon column chromatographic separation, together with 7 known compounds, 5 phenolic glycosides, androsin (2), 17) (Ϫ)-syringaresinol glucoside (3), 18) homoarbutin (6), 4,10) hyperin (11), 4,5,12) pirolatin (12) 8,9) together with an iridoid, monotropein (1) 4,7) and a naphthoquinone, chimaphilin (9). 3,5,6,19) TLC analysis of the acid hydrolysates of 4, 5, 7, 8, and 10 indicated the presence of glucose in 4, 5, 7, and 8, and glucose and xylose in 10.…”

LC-MS Method for Determination and Pharmacokinetic Study of Chimaphilin in Rat Plasma after Oral Administration of the Traditional Chinese Medicinal Preparation Lu Xian Cao Decoction

“…6) Chimaphilin also contributed to both inotropic and platelet aggregation inhibitory activity of Pyrola plants. 7) In addition, the cytotoxic active component in Pyrola incarnata against L1210 and K562 cells isolated by bioassay-guided method gave rise to chimaphilin. 8) Thus chimaphilin plays an important role in the bioactivity of Lu xian cao; using chimaphilin as one of the marker compounds to characterize Lu xian cao is reasonable.…”