2006
DOI: 10.1248/bpb.29.2523
|View full text |Cite
|
Sign up to set email alerts
|

LC-MS Method for Determination and Pharmacokinetic Study of Chimaphilin in Rat Plasma after Oral Administration of the Traditional Chinese Medicinal Preparation Lu Xian Cao Decoction

Abstract: Lu xian cao (Hebra pyrolae) is a traditional Chinese medicine used for the treatment of several major diseases. Chimaphilin has been demonstrated one of the major active components in Lu xian cao by modern pharmacological studies. In this study, a liquid chromatography-mass spectrometry method for the determination of chimaphilin in rat plasma was developed and validated. The separation was carried out on a C 18 column using methanol and water as mobile phase after the plasma sample was extracted with diethyl … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
5
0

Year Published

2010
2010
2020
2020

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 8 publications
(5 citation statements)
references
References 6 publications
0
5
0
Order By: Relevance
“…Chimaphilin is a kind of naphthoquinones. It possesses anti-inflammatory and analgesic properties (Babula et al, 2006;Ribeiro et al, 2009;Zang et al, 2006). Efficient extraction of main active compounds from P. incarnata is a rational strategy to increase the economic value of this plant.…”
Section: Contents Lists Available At Sciencedirectmentioning
confidence: 99%
“…Chimaphilin is a kind of naphthoquinones. It possesses anti-inflammatory and analgesic properties (Babula et al, 2006;Ribeiro et al, 2009;Zang et al, 2006). Efficient extraction of main active compounds from P. incarnata is a rational strategy to increase the economic value of this plant.…”
Section: Contents Lists Available At Sciencedirectmentioning
confidence: 99%
“…45) Additionally, this compound showed the ability to improve the functioning of the muscular system and lipid and protein metabolism in first-and secondtype diabetic patients. 46) 2.4. Anti-inflammatory and Analgesic Properties Anti-inflammatory and analgesic properties of a number of naphthoquinones have been discovered.…”
Section: Cardioprotective and Anti-ischemic Propertiesmentioning
confidence: 99%
“…In subsequent studies, the biologically active nucleus of natural quinones was modified by organic synthesis 63,64) and the newly obtained biologically active derivatives of these 1,4-naphthoquinones were patented. 65) The efficacy of a series of 2-hydroxy-3-phenylsulfanylmethyl- [ (46) (Fig. 11) showed higher susceptibility to bloodstream trypomastigotes and exhibited a greater efficacy against trypomastigotes from different T. cruzi of Brazil and CL strains through the induction of intracellular autophagy and elevation of ROS level, leading to parasite death.…”
Section: Cardioprotective and Anti-ischemic Propertiesmentioning
confidence: 99%
See 1 more Smart Citation
“…[ 15 16 ] Moreover, the dried whole plant of Pyrola decorata H. Andres has been used as tonics, sedatives, hemostatics, anti-inflammatory, and analgesics against RA in China since the antiquity. [ 17 ] Cinnamomum cassia Presl is used as an analgesic and anti-pyretic against influenza and rheumatic pain. [ 18 ] Lonmicera japonica Thunb and Morus alba L were also investigated in various inflammatory models.…”
Section: Introductionmentioning
confidence: 99%