Platelet Aggregation Increased by Advanced Glycated Hemoglobin

M, Asadifar M Bakhti

doi:10.4172/2155-9864.1000293

Cited by 4 publications

(5 citation statements)

References 43 publications

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“…The fact that, in our study, neither T2DM nor HbA1c was associated with higher platelet reactivity ( Supplementary Table S2 ) appears to be discordant with the results of some previous studies [ 20 , 39 , 40 ]. However, these conflicting results could be a consequence of the dependence of platelet reactivity on multiple factors, including glycemic variability [ 40 ] and short-term hyperglycemia [ 41 ], a fact not reflected by HbA1c.…”

Section: Discussionsupporting

confidence: 85%

Association of ADP-Induced Whole-Blood Platelet Aggregation with Serum Low-Density Lipoprotein Cholesterol in Patients with Coronary Artery Disease When Receiving Maintenance Ticagrelor-Based Dual Antiplatelet Therapy

Chyrchel

Kruszelnicka

Wieczorek-Surdacka

et al. 2023

JCM

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The degree of platelet inhibition in patients undergoing dual antiplatelet therapy (DAPT) affects cardiovascular outcomes after acute coronary syndromes (ACS) and/or percutaneous coronary intervention. Our aim was to search for correlates of residual ex vivo platelet reactivity and circulating soluble P-selectin (sP-selectin), an index of in vivo platelet activation, in patients being treated by DAPT with ticagrelor. Adenosine diphosphate (ADP)-induced platelet aggregability (by multiple electrode aggregometry) and plasma sP-selectin were estimated in 62 stable post-ACS subjects (46 men and 16 women; mean age: 64 ± 10 years; 30 with type 2 diabetes (T2DM)) undergoing maintenance DAPT with ticagrelor and aspirin. These patients did not exhibit heart failure or other relevant coexistent diseases except for properly controlled T2DM, mild renal insufficiency, and hypertension. We also assessed this in 64 subjects on clopidogrel-based DAPT matched for age, sex, and T2DM status. ADP-induced platelet aggregation was below the optimal levels (190–460 arbitrary units (AU) * min) in most patients receiving ticagrelor-based DAPT, especially in those with below-median (<1.9 mmol/L) serum concentrations of low-density lipoprotein cholesterol (LDL-c) (128 ± 61 vs. 167 ± 73 AU * min for below-median and above-median LDL-c, respectively, p = 0.025). In contrast, platelet reactivity did not differ by LDL-c on clopidogrel-based DAPT (246 ± 101 vs. 268 ± 108 AU * min for below-median and above-median LDL-c, respectively, p > 0.4). Plasma sP-selectin was found to be unrelated to serum LDL-c when receiving DAPT with ticagrelor (p > 0.4) or clopidogrel (p > 0.8). In conclusion, our preliminary observational study suggests the association of lower residual ex vivo platelet aggregability with better LDL-c control in patients undergoing ticagrelor-based maintenance DAPT, which does not appear to be reflected by plasma sP-selectin. Whether the serum LDL-c level should be considered among the factors affecting the degree of platelet inhibition for those treated with ticagrelor-based DAPT needs to be investigated in larger studies.

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Section: Discussionsupporting

confidence: 85%

Association of ADP-Induced Whole-Blood Platelet Aggregation with Serum Low-Density Lipoprotein Cholesterol in Patients with Coronary Artery Disease When Receiving Maintenance Ticagrelor-Based Dual Antiplatelet Therapy

Chyrchel

Kruszelnicka

Wieczorek-Surdacka

et al. 2023

JCM

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“…Although this study did not establish a relationship between pathological values of HbA1c and the occurrence of this complication, it can be understood that the endothelial dysfunction caused by high levels of HbA1c and by Advanced glycation end-products would be one of the pathophysiological mechanisms. In the study by Asadifar et al [77], it was shown that high levels of HbA1c also favored aggregability and the platelet activation which would be responsible for the formation of microthrombi and multi visceral attack which can lead HELLP syndrome.…”

Section: Glycated Hemoglobin and Preeclampsia Prognosismentioning

confidence: 99%

The Profile of Glycated Hemoglobin in Non-Diabetic Pregnant Women with Preeclampsia: A Case-Control Study in Kinshasa, the Democratic Republic of Congo

Luzolo¹,

Beya²,

Numbi³

et al. 2020

OJOG

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Background: A disturbed glucose metabolism is quite common during pregnancy. It is due to the diabetogenic potential of pregnancy and responsible for many obstetric complications. The glycated hemoglobin is one of the markers used to depict these disorders. Higher concentrations of this marker would be associated with unfavorable results of pregnancy. Objective: To describe the profile of HbA1c in non-diabetic preeclamptic pregnant women and to establish the association between the values of this marker and the maternal and fetal complications. Materials and Method: This is a case-control study of 142 pregnant women in their second and third trimester. They were followed in the maternity hospitals of University Clinics and the General Reference Hospital in Kinshasa, Democratic Republic of Congo between May and October 2019. The sampling of preeclamptic pregnant women was exhaustive.

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“…Although other hormonal, neuronal, and functional factors are chronically affected as well. In the DMAFs subjects, this is due to either the pancreas not producing enough insulin or the cells of the body not responding properly to the insulin produced, [3][4][5][6][7][8][9][10][11] increasing BLEC-dependent disorders eventually. If DMAFs patients are left untreated, collateral damage and side effects of too much glucose lead to many health complications i.e., platelets hyper-and/or hypo-activities, which both are very dangerous progression when chronically prolonged [4][5][6].…”

mentioning

confidence: 99%

“…In the DMAFs subjects, this is due to either the pancreas not producing enough insulin or the cells of the body not responding properly to the insulin produced, [3][4][5][6][7][8][9][10][11] increasing BLEC-dependent disorders eventually. If DMAFs patients are left untreated, collateral damage and side effects of too much glucose lead to many health complications i.e., platelets hyper-and/or hypo-activities, which both are very dangerous progression when chronically prolonged [4][5][6]. Whether a diabetes patient could be clinically supported in such a way that does not need any medicinal/therapeutic management is a big desired wish of any DMAFs, who are suffering from chronic insulin injection, drug usage, obesity discomfort, and an increased morbidity/mortality risk.…”

mentioning

confidence: 99%

“…Why human blood platelets do react to hyperglycemia conditions differently? [4][5][6] Inconsistent platelets reaction either hyperactivity or hypo-activity in certain groups of DMAFs' patients despite their diabetic background were observed to be the same i.e., all diabetes mellitus type 2 patients. There are big missing links and regrettably (with all due respect) know-how still missing, which are both affecting DMAFs' patients' morbidity and mortality rates, however.…”

mentioning

confidence: 99%

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Diabetic Processes are Potentially Reversible

Badlou¹

2023

Series Endo Diab Met.

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Diabetes mellitus all forms (DMAFs) could be said to be a metabolic syndrome with and without obesity-associated bloated disease, neuronal stress, and chronically pathophysiologic disorder -a kind of accumulation disease associated with mainly dysfunctional glucose, insulin, and fat metabolism diseases which might become a popular disease combination number 1, soon.DMAFs are not only a simple metabolic disorder that affects the lives of different subjects significantly and increases mortality and morbidity rates when too late diagnosed, but also are "clinical and laboratories' failure indicating-end results" concerning National Health status. Consequently, one should make a very long description of DMAFs, which unfortunately are not defined yet, appropriately. Untreated or poorly treated diabetes accounts for approximately 1.5 million deaths per year [1]. The U.S. Centers for Disease Control and Prevention indicates that about 79 million American adults over the age of 20 have prediabetes. An estimated 30-40 million Americans have diabetes, a disease in which there is too much sugar in the bloodstream. Between 7-10 million of them, however, have not yet been diagnosed with the disease. The number of adults with diabetes in the world has increased from 108 million in 1980 to 422 million in 2014 due to a rise in prevalence, population growth, and aging [1]. Diabetes mellitus has been projected to become the 7th leading cause of death in 2030 [1, 2]. It has been estimated that the direct medical costs of diabetes to the world are more than the United States > 827 million dollars [2]. If we look at different developed countries, almost half of the USA and Dutch population is overweight now, and almost one to six are even seriously overweight in The Netherlands. That means too much fat storage, especially belly fat, blown up unhealthy either subcutaneous or visceral fat. Recall in human fat tissue hundreds of types of hormones are produced, and essentially each second after any noxious stimuli communicate with the different vital organs like the heart, lung, gastrointestinal tract, and brain axis (HLGB axis) in a bidirectional positive and negative feedback via neuronal, hormonal, lymphatic circulations (NHLC).

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Platelet Aggregation Increased by Advanced Glycated Hemoglobin

Cited by 4 publications

References 43 publications

Association of ADP-Induced Whole-Blood Platelet Aggregation with Serum Low-Density Lipoprotein Cholesterol in Patients with Coronary Artery Disease When Receiving Maintenance Ticagrelor-Based Dual Antiplatelet Therapy

Association of ADP-Induced Whole-Blood Platelet Aggregation with Serum Low-Density Lipoprotein Cholesterol in Patients with Coronary Artery Disease When Receiving Maintenance Ticagrelor-Based Dual Antiplatelet Therapy

The Profile of Glycated Hemoglobin in Non-Diabetic Pregnant Women with Preeclampsia: A Case-Control Study in Kinshasa, the Democratic Republic of Congo

Diabetic Processes are Potentially Reversible

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