Platelet Aggregation Following Heparin and Protamine Administration

RETRACTED ARTICLE: Does continuous heparinization influence platelet function in the intensive care patient?

“…Most cardiac surgery patients are treated with a variety of different substances (e. g., aspirin, nitroglycerine), which are thought to have a marked influence platelet function [30]. Additionally, subsequent cardiopulmonary bypass may influence platelet function independently of heparin [9,30]. Others have studied the sequelae of heparin administration in the experimental setting [21,31].…”

“…Whether or not heparin has an effect on platelet function, however, is a controversial issue. Heparin has been reported to reduce [7,8] and enhance [9,10] platelet aggregation. Unfractionated "standard" heparin appears to be considerably more active in modifying platelet aggregation than low-molecular weight heparin [11].…”

Hemostatic function and inflammatory activation after weaning from cardio pulmonary bypass

“…The cause of the dysfunction is incompletely understood but contact with foreign material, hypothermia, hemodilution and pharmaceuticals are factors that affects the platelets 41 . Previous studies has suggested that the interaction between the heparin-protamine complex and platelets can affect platelet aggregation 128 . Platelet function could be affected at different heparin-protamine ratios 6 , and excessive protamine has been suggested to contribute to the dysfunction 34,129 .…”

Cardiopulmonary bypass technology transfer: musings of a cardiac surgeon

“…Other biomaterial-independent factors contributing to platelet activation (and subsequent dysfunction) after CPB include heparin at the doses used for CPB [92], activated complement [93], plasmin [94] and a variety of other soluble blood elements. Platelets adhere to binding sites located on surface-adsorbed brinogen and form aggregates [95].…”