Platelet aggregation during menstrual cycle and pregnancy

Yamazaki, Hiroh; Motomiya, Takeshi; Kikutani, Norihisa; Sakakibara, Chieko; Watanabe, Setsuko; Numata, Masahiro; Noguchi, Kunio

doi:10.1016/0049-3848(79)90242-1

Cited by 32 publications

(14 citation statements)

References 6 publications

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“…To some extent, the cAMP levels we observed in platelets are congruous with those reported in the brain [1] and this is in agreement with the sugges tion of Bloomfield et al [7]. The conclusion to be drawn from this study is that gender difference in platelet function is not a simple reflection of hormonal levels or of adenylate cyclase activity of platelets.…”

Section: Discussionsupporting

confidence: 81%

“…The sensitivity of platelets has been sug gested to be a function of sex hormones and changes have been reported in platelet reac tivity to aggregating agents during the oestrous cycle in the rat [4,5]. Similar observa tions have been reported in women during the menstrual cycle and following the admin istration of contraceptive hormones [6,7], There has been much obsession with gender difference in platelet reactivity and the dogma has been to implicate oestradiol or testosterone in inhibiting or potentiating platelet reactivity, respectively.…”

Section: Discussionsupporting

confidence: 60%

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There Is No Evidence of Sexual Dimorphism in Platelet Reactivity in the Rat

Oyekan

1988

Pharmacology

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Changes in platelet reactivity (in vivo) to adenosine diphosphate (ADP) were evaluated in intact male and female rats, gonadectomized rats (with or without hormonal treatment with oestradiol or testosterone), feminized and androgenized rats (with or without hormonal treatment with oestradiol and testosterone). The 3’,5’-cyclic adenosine monophosphate (cAMP) content of the respective platelet suspensions was also determined simultaneously. Changes recorded in platelet reactivity to ADP showed striking changes unreflective of endocrine status. No consistent concomitant changes were observed in the cAMP content of the respective platelet suspensions. The data obtained casts doubts on the presence of sexual dimorphism in platelet reactivity. A dependence of platelet reactivity on hormones per se as well as the second messenger role for cAMP in platelet reactivity also raises some doubts.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 60%

There Is No Evidence of Sexual Dimorphism in Platelet Reactivity in the Rat

Oyekan

1988

Pharmacology

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“…Some investigators found increased aggregability to ADP and adrenaline during pregnancy. 21,27,41 Our results disagree with these observations, since the aggregation responses to ADP, adrenaline, arachidonic acid, collagen, and ristocetin were significantly lower during pregnancy compared to nonpregnant controls. In contrast, other investigators could not establish any differences between pregnant and nonpregnant women.…”

Section: Discussioncontrasting

confidence: 57%

“…Reports on platelet count in pregnancy have provided discordant results. In most studies, no significant changes were observed, 11,15,21,26,27 while in others, like our own, a slight reduction was found. 15,28,29 In contrast to these findings, Mor et al 30 found a marked and progressive increase in the platelet count during pregnancy and a sharp drop at the time of placental delivery.…”

Section: Discussionmentioning

confidence: 76%

Hemostasis in Pregnant Saudi Women

et al. 1990

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A cross-sectional study of various hemostatic variables was undertaken in women during the three trimesters of normal pregnancy. In the third trimester of pregnancy, there was significant elevation of plasma fibrinogen, 55%; factor VIII activities, 64%; factor VIII:ristocetin cofactor, 44% ; factor VIII-related antigen, 49% ; factor X, 9% ; and plasminogen, 19%, and a reduction of antithrombin III, 10%; alpha2-antiplasmin, 7%; and platelet count, 20%, compared with those values obtained in healthy nonpregnant controls. These fluctuations developed gradually during the first and second trimesters. Prothrombin time, partial thromboplastin time, thrombin time, and reptilase time were similar in pregnant women and nonpregnant controls. Platelet aggregation in response to adenosine diphosphate, collagen, adrenaline, and arachidonic acid was significantly reduced in pregnant women compared to controls. The reduced platelet aggregability in Saudi pregnant women may counterbalance the increased plasmatic coagulation potential, thereby minimizing the risk of thromboembolic disease during pregnancy.

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“…1979], Although a platelet count was not included, it has been previously shown that there is no significant change in platelet counts during the premenstrual phase [Yamazaki et al, 1979;Baron et al, 1980]. It seems unlikely, therefore, that the decreased 5-HT uptake, result ing from the lowering of Vmax during premenstrual tension, is due solely to a change in the number of platelets.…”

Section: Discussionmentioning

confidence: 99%

Serotonin Levels and Platelet Uptake during Premenstrual Tension

et al. 1984

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Premenstrual tension was studied in 16 females, using both biochemical and psychological parameters during the pre- and postmenstrual phases. Uptake of serotonin (5-HT) and the levels of 5-HT in platelet-rich plasma and platelet-poor plasma were determined. Degrees of distress experienced pre- and postmenstrually were quantified via the Moos menstrual distress questionnaire. The mean V_max was significantly lower during the premenstrual (tension) phase (8.2 ± 0.9 pmol/min) as compared to the postmenstrual (normal) phase (14.4 ± 3.2 pmol/min). There was no significant difference in the K_m values. A highly significant (p < 0.001) reduction in the levels of 5-HT in platelet-rich plasma (–23.2%) and platelet-poor plasma (-19.1%) was found during the premenstrual phase. There were correlations between the kinetic parameters of 5-HT uptake and some of the Moos symptoms.

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Platelet aggregation during menstrual cycle and pregnancy

Cited by 32 publications

References 6 publications

There Is No Evidence of Sexual Dimorphism in Platelet Reactivity in the Rat

There Is No Evidence of Sexual Dimorphism in Platelet Reactivity in the Rat

Hemostasis in Pregnant Saudi Women

Serotonin Levels and Platelet Uptake during Premenstrual Tension

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