Serotonin Levels and Platelet Uptake during Premenstrual Tension

Taylor, Dorothy; Mathew, Roy J.; Ho, Beng T.; Weinman, Maxine L.

doi:10.1159/000118103

Cited by 118 publications

(40 citation statements)

References 5 publications

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“…Our finding is contradictory to the finding of Taylor et al [1984], who found that Vmax was decreased, al though not markedly so, during the luteal phase of the menstrual cycle in women with PMS. In their study, however, the Vmax values were obtained without deter minations of the platelet count.…”

Section: Discussioncontrasting

confidence: 99%

Platelet Serotonin Uptake and Effects of Vitamin B<sub>6</sub>-Treatment in Premenstrual Tension

Malmgren¹,

Collins²,

Nilsson

1987

Neuropsychobiology

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The platelet serotonin uptake kinetics was studied in 19 women with premenstrual tension syndrome (PMS) and 19 age-matched symptom-free controls during the pre- and postmenstrual phases. Both groups exhibited stable V_max and K_m values at the two phases of the menstrual cycle. There were no differences between the two groups regarding the level of V_max and K_m, respectively. The effect of season (p < 0.001), with lowered values of V_max during spring compared to corresponding values during the later half of the year, was identical in both groups. A tendency to lowered V_max values in the follicular phase in women with PMS during spring may indicate that women with PMS are more vulnerable to developing depressive episodes during this period than symptom-free women. The blood platelet count in whole blood was decreased in the luteal phase in the control group but remained stable in the PMS group. The effect of vitamin B₆ on clinical symptoms and the platelet serotonin uptake during the luteal phase was investigated in a double-blind crossover design. Vitamin B₆ treatment did not significantly improve the PMS symptoms. There was no effect of treatment on K_m. V_max increased significantly in response to treatment (F = 9.6; p < 0.001) in both groups, but there was no significant difference between placebo and vitamin B₆.

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Section: Discussioncontrasting

confidence: 99%

Platelet Serotonin Uptake and Effects of Vitamin B<sub>6</sub>-Treatment in Premenstrual Tension

Malmgren¹,

Collins²,

Nilsson

1987

Neuropsychobiology

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“…The greater increase in allopregnanolone concentrations after administration of L-TP in women with PMS compared with controls most probably reflects the lower baseline serotonergic activity in this group of women, as has been suggested by us and others (1,2,37,38). Therefore any mechanism by which central serotonergic activity is increased, as with the administration of L-TP in our study, or after administration of SSRIs ± especially if the baseline central serotonergic activity is low ± is likely to increase allopregnanolone concentrations to a greater degree than when the central serotonergic activity is high.…”

Section: Discussionsupporting

confidence: 55%

“…Serotonergic dysfunction as a potential cause of premenstrual syndrome (PMS) has been postulated on the basis of decreased concentrations of whole-blood serotonin and diminished platelet uptake of serotonin (1,2). This concept has been supported by studies demonstrating the effectiveness of selective serotonin reuptake inhibitors (SSRIs) in the treatment of premenstrual dysphoric disorder (PMDD), a severe form of PMS (3,4).…”

Section: Introductionmentioning

confidence: 99%

Neuroactive steroid-serotonergic interaction: responses to an intravenous L-tryptophan challenge in women with premenstrual syndrome

Rasgon

Serra²,

Biggio³

et al. 2001

European Journal of Endocrinology

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Objective: To evaluate the circulating concentrations of the neuroactive steroids in response to an i.v. L-tryptophan (L-TP) challenge across the menstrual cycle in women with premenstrual syndrome (PMS) and in controls. Method: An i.v. L-TP challenge was administered eight times during 1 month to five women with prospectively documented PMS and five age-and body mass-matched controls. Progesterone, allopregnanolone pregnenolone and 3a-5a-tetrahydrocorticosterone were assessed 15 and 0 min before, and at 30, 60 and 90 min after the challenge, across the menstrual cycle. Results: In response to L-TP challenge, only allopregnanolone concentrations were significantly increased across the cycle and this increase was of a greater magnitude in women with PMS. Pregnenolone and 3a-5a-tetrahydrocorticosterone concentrations were not affected in women with PMS or controls after L-TP challenge. Conclusions: The data provide evidence for possible interaction between the serotonergic system and the neuroactive steroid, allopregnanolone. Women with PMS demonstrated a more significant increase in allopregnanolone concentrations in response to L-TP challenge, which could be due to an initial low basal serotonergic tone in the luteal phase in the PMS group.

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“…10,11 Evidence suggests that serotonin may play an important role in the pathophysiology of PMS. [12][13][14] But other neurotransmitters and neuromodulators, in particular the gammaaminobutyric acid (GABA), adrenergic, and opioid systems, have also been implicated in the pathophysiology of PMS and PMDD. [15][16][17] Venlafaxine is a novel bicyclic antidepressant that inhibits neuronal re-uptake of serotonin and norepinephrine.…”

Section: Introductionmentioning

confidence: 99%

Effective open‐label treatment of premenstrual dysphoric disorder with venlafaxine

Hsiao

Liu

2003

Psychiatry Clin Neurosci

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Various studies have demonstrated the efficacy of selective serotonergic re-uptake inhibitors in the treatment of premenstrual dysphoric disorder (PMDD). But the effectiveness of novel antidepressant, venlafaxine, in PMDD has been reported in only one Western study. The purpose of the present open-label study was to provide preliminary data on the effectiveness of venlafaxine for Asian women with PMDD. Thirty women with PMDD were enrolled and treated with a flexible dosage of venlafaxine for two menstrual cycles. Responses were assessed every 2 weeks. Outcome measures included the scores of the Prospective Record of the Impact and Severity of Menstrual

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Serotonin Levels and Platelet Uptake during Premenstrual Tension

Cited by 118 publications

References 5 publications

Platelet Serotonin Uptake and Effects of Vitamin B<sub>6</sub>-Treatment in Premenstrual Tension

Platelet Serotonin Uptake and Effects of Vitamin B<sub>6</sub>-Treatment in Premenstrual Tension

Neuroactive steroid-serotonergic interaction: responses to an intravenous L-tryptophan challenge in women with premenstrual syndrome

Effective open‐label treatment of premenstrual dysphoric disorder with venlafaxine

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