Platelet aggregation, blood viscosity and serum lipids in hypertensive and obese children

Haszon, Ibolya; Papp, Ferenc; Kovács, József; Borş, M; Németh, Ilona; Bereczki, Csaba; Túri, Sándor

doi:10.1007/s00431-003-1156-4

Cited by 19 publications

(23 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…20 In addition, previous studies have reported that hypertension is associated with an increase in platelet reactivity. 21,22 However, it is unlikely that diminished platelet reactivity in the potassium-supplemented group was mediated through blood pressure because potassium supplementation for 3 days had no significant effect on blood pressure.…”

Section: Kimura Et Al Potassium and Platelet Reactivity 971mentioning

confidence: 99%

Potassium Chloride Supplementation Diminishes Platelet Reactivity in Humans

Kimura¹,

Xiao-bin²,

Skurnick³

et al. 2004

Hypertension

View full text Add to dashboard Cite

Abstract-The prevalence of occlusive stroke is inversely correlated with potassium intake. We explored the hypothesis that a high potassium intake attenuates platelet reactivity, as expressed in ADP-evoked platelet aggregation. We studied healthy men (nϭ31) and women (nϭ42), blacks (nϭ33) and whites (nϭ40). In this cohort, we supplemented the habitual intake of 17 men and 21 women with 60 mmol KCl/70 kg body weight per day for 3 days and maintained 14 men and 21 women on their habitual intake. We then compared the change in ADP concentration causing 50% of the maximal initial rate (EC 50 ) of platelet aggregation in the potassium-supplemented versus control groups. Potassium supplementation attenuated platelet reactivity, expressed by an increase in EC 50 of platelet aggregation (Pϭ0.0005), which was primarily attributable to an increase in EC 50 in whites (Pϭ0.0004). Urinary potassium excretion was significantly lower in blacks than in whites under basal conditions and after potassium supplementation. We conclude that potassium supplementation diminishes platelet reactivity, a phenomenon that provides a link between platelet biology and occlusive stroke. Key Words: stroke Ⅲ cardiovascular disease Ⅲ atherosclerosis T he potential cardiovascular benefits of dietary potassium in the general population have been considered primarily from the perspectives that potassium may serve as a sodium substitute in the diet and that a high potassium intake enhances natriuresis. 1 Accordingly, the beneficial effect of a high dietary potassium intake on the cardiovascular system would presumably be mediated by the concomitant reduction in dietary sodium intake, coupled with enhanced sodium excretion, as well as other mechanisms that may ultimately lower blood pressure. 2 The question that follows is whether or not the cardiovascular effect of a high potassium intake may also be mediated through blood pressure-independent mechanisms, given that large-scale studies strongly suggest that dietary potassium intake is inversely correlated with occlusive stroke, a relationship that is independent of the effect of potassium intake on blood pressure. [3][4][5][6][7] Further, in the Systolic Hypertension in the Elderly Program (SHEP) within the treatment group, the risk for cardiovascular events, including stroke and myocardial infarction, was significantly higher in subjects with hypokalemia (serum potassium Ͻ3.5 mmol/L) associated with diuretic use. 8 Collectively, these findings suggest a link between systemic potassium homeostasis and atherosclerosis and thrombosis. 9,10 We note, however, that potassium is primarily an intracellular ion, so that dietary intake and diuretic use are likely to have an effect on intracellular potassium pool even without detectable changes in serum potassium.Because thromboembolic processes largely depend on platelet biology, we hypothesized that a high potassium intake would diminish platelet reactivity. This concept was explored in the present work. Materials and Methods SubjectsWe studied healthy men (...

show abstract

Section: Kimura Et Al Potassium and Platelet Reactivity 971mentioning

confidence: 99%

Potassium Chloride Supplementation Diminishes Platelet Reactivity in Humans

Kimura¹,

Xiao-bin²,

Skurnick³

et al. 2004

Hypertension

View full text Add to dashboard Cite

show abstract

“…They showed elevated plasma viscosity, higher whole blood viscosity at both low and high shear rates and prolonged erythrocyte filtration time in obese Italian children and adolescents [4] and elevated plasma viscosity and erythrocyte aggregation in Spanish children with familiar hypercholesterolaemia [9]. Hypertensive obese children from Hungary had an elevated plasma viscosity, blood viscosity and platelet aggregation [13]. A relation between plasma viscosity, fibrinogen and the prevalence of hypertension in diabetic Turkish children [5] and improvements of the haemorheological profile upon dietary intervention in obese Italian adolescents [11] have also been documented.…”

Section: Introductionmentioning

confidence: 99%

Association of hyperviscosity and subclinical atherosclerosis in obese schoolchildren

Zhu

Huang

et al. 2005

Eur J Pediatr

View full text Add to dashboard Cite

show abstract

“…In overweight children, irrespectively of hypertension, a non-significant decrease in plasma NO x was observed. In a previous study from our group a marked decrease was seen in plasma NO x in non-obese and also in obese hypertensive patients [44]. These data suggest that endothelial dysfunction, characterized by decreased plasma NO x may be a more important mechanism in EH of lean patients than in OH, but the presence of endothelial dysfunction is detectable in obesity and OH.…”

Section: Question 2 Does No Production Which Is Characterized By Plsupporting

confidence: 67%

“…Increased in vitro platelet aggregation and thromboxane B 2 (stable degradation product of TxA 2 ) levels were observed in hypertensive children [43]. In a second study, the increased platelet aggregability was also confirmed in non-obese and obese hypertensive children, and simultaneously, decreased NO and depletion of plasma free thiols, -as the sign of oxidant injury -were demonstrated in both groups of hypertensives [44]. Increase in platelet aggregation releases …”

Section: Endothelial Dysfunctionmentioning

confidence: 99%

Pathogenetic studies in juvenile essential hypertension and uremia

Papp

Self Cite

View full text Add to dashboard Cite

Platelet aggregation, blood viscosity and serum lipids in hypertensive and obese children

Abstract: in obese children an increased platelet aggregation and oxidative insult contribute to the development of hypertension and to the promotion of vascular damage.

Cited by 19 publications

References 26 publications

Potassium Chloride Supplementation Diminishes Platelet Reactivity in Humans

Potassium Chloride Supplementation Diminishes Platelet Reactivity in Humans

Association of hyperviscosity and subclinical atherosclerosis in obese schoolchildren

Pathogenetic studies in juvenile essential hypertension and uremia

Contact Info

Product

Resources

About