Association of hyperviscosity and subclinical atherosclerosis in obese schoolchildren

Zhu, Weihua; Li, Mengxia; Huang, Xian-Mei; Neubauer, Henning

doi:10.1007/s00431-005-1725-9

Cited by 14 publications

(6 citation statements)

References 24 publications

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“…The aim of the present study was to compare EA in a group of obese patients without type 2 diabetes, arterial hypertension, or dyslipidemia and in a control group and to determine whether this rheological parameter shows significant changes with weight loss obtained with diet treatment. Like us, most authors have found higher values of EA indices in obese patients compared with a control group (2, 3, 4, 5, 6, 7, 8), using a Myrenne aggregometer, one of the most commonly used in clinical hemorheology laboratories because of its easy handling and reproducibility (17). EA has not only been evaluated in the present study with a Myrenne aggregometer but also with a Sefam aggregometer, which supplies additional information on the EA process, assessing the extent of aggregates, Ta and γD, i.e., the shear rate required to disaggregate the rouleaux.…”

Section: Discussionmentioning

confidence: 86%

“…Alterations in the hemorheological profile in obese patients may promote, in addition to other mechanisms, the development of atherothrombotic and thromboembolic events. In this setting, among the hemorheological factors, erythrocyte aggregation (EA) 1 has been reported to show the most contradictory results (2, 3, 4, 5, 6, 7, 8). The studies performed in obese patients have evaluated aggregation index (IA), and only two of them have determined the ability of erythrocyte rouleaux to be dissociated into individual red blood cells by means of the total disaggregation threshold (γD) needed for erythrocytes to disaggregate (6, 9), which is an important contribution to the knowledge of rouleaux characteristics, and, therefore, of its ability to promote thrombus formation.…”

Section: Introductionmentioning

confidence: 99%

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Erythrocyte Hyperaggregation in Obesity: Determining Factors and Weight Loss Influence

Solá

Vayá

Corella

et al. 2007

Obesity

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Research Methods and Procedures:This was a longitudinal, clinical intervention study of a very low-calorie diet for 4 weeks followed by a low-calorie diet for 2 months. In 67 severely obese patients, an anthropometric and analytical evaluation [plasmatic lipids, fibrinogen (Fbg), and EA] was performed at baseline and 3 months after diet. The same determinations were performed in 67 normal-weight volunteers. EA was measured with the Myrenne MA 1 , which determines EA at stasis (EA 0 ) and at a low shear of 3 seconds Ϫ1 (EA 1 ), and the Sefam aggregometer, which determines aggregation index at 10 seconds Ϫ1 (IA 10 ), aggregation time (Ta), and disaggregation threshold (␥D). Insulin resistance (IR) was calculated by homeostasis model assessment. Results: Obese patients showed higher Fbg levels, EA 0 , EA 1 , IA 10 , and ␥D values, and lower Ta values. Differences between obese patients and control group for EA 0 , EA 1 , Ta, IA 10 , and ␥D disappeared after adjusting for BMI or for homeostasis model assessment but were maintained after adjusting for Fbg or low-density lipoprotein-cholesterol. Obese patients with IR showed higher EA 0 and EA 1 values. After weight loss, EA 1 showed a significant improvement. Discussion: Obese patients show increased EA. Erythrocyte hyperaggregation does not seem to be related to a high Fbg level or to an abnormal lipid profile but to IR. Hyperagreggation improves after weight loss.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Erythrocyte Hyperaggregation in Obesity: Determining Factors and Weight Loss Influence

Solá

Vayá

Corella

et al. 2007

Obesity

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“…Results from this study cohort linking intima-media thickening and endothelial dysfunction to childhood obesity and to hyperviscosity have been reported before [31,32]. We defined obesity as having a body weight above the 95% percentile on age-specific and gender-specific Chinese growth charts.…”

Section: Subjectsmentioning

confidence: 92%

Elevated plasma homocysteine in obese schoolchildren with early atherosclerosis

Zhu

Huang

et al. 2005

Eur J Pediatr

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“…Although we did not measure blood viscosity in this study, it is well known that viscosity is increased in animals fed with an atherogenic diet [35] and in hypercholesterolemic patients [36]. The increase in blood viscosity previously reported varies from 0.8% to 8.2% [37], [38], [39]. In hemodynamic studies of early atherosclerotic changes [26], vascular resistance was found to be increased in the resting state and also during maximal vasodilation.…”

Section: Discussionmentioning

confidence: 69%

Compensatory enlargement of Ossabaw miniature swine coronary arteries in diffuse atherosclerosis

Choy

Luo

Huo

et al. 2015

IJC Heart & Vasculature

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Studies in human and non-human primates have confirmed the compensatory enlargement or positive remodeling (Glagov phenomenon) of coronary vessels in the presence of focal stenosis. To our knowledge, this is the first study to document arterial enlargement in a metabolic syndrome animal model with diffuse coronary artery disease (DCAD) in the absence of severe focal stenosis. Two different groups of Ossabaw miniature pigs were fed a high fat atherogenic diet for 4 months (Group I) and 12 months (Group II), respectively. Group I (6 pigs) underwent contrast enhanced computed tomographic angiography (CCTA) and intravascular ultrasound (IVUS) at baseline and after 4 months of high fat diet, whereas Group II (7 pigs) underwent only IVUS at 12 months of high fat diet. IVUS measurements of the left anterior descending (LAD), left circumflex (LCX) and right coronary (RCA) arteries in Group I showed an average increase in their lumen cross-sectional areas (CSA) of 25.8%, 11.4%, and 43.4%, respectively, as compared to baseline. The lumen CSA values of LAD in Group II were found to be between the baseline and 4 months values in Group I. IVUS and CCTA measurements showed a similar trend and positive correlation. Fractional flow reserve (FFR) was 0.91±0.07 at baseline and 0.93±0.05 at 4 months with only 2.2%, 1.6% and 1% stenosis in the LAD, LCX and RCA, respectively. The relation between percent stenosis and lumen CSA shows a classical Glagov phenomenon in this animal model of DCAD.

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Association of hyperviscosity and subclinical atherosclerosis in obese schoolchildren

Abstract: Hyperviscosity is related to subclinical atherosclerosis in obese schoolchildren. Viscosity parameters contribute new information in addition to body mass index, blood pressure and blood lipids and may help to facilitate risk stratification in obese paediatric patients.

Cited by 14 publications

References 24 publications

Erythrocyte Hyperaggregation in Obesity: Determining Factors and Weight Loss Influence

Erythrocyte Hyperaggregation in Obesity: Determining Factors and Weight Loss Influence

Elevated plasma homocysteine in obese schoolchildren with early atherosclerosis

Compensatory enlargement of Ossabaw miniature swine coronary arteries in diffuse atherosclerosis

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