Platelet Adhesion to Foreign Surfaces Under Controlled Conditions of Whole Blood Flow

Ef, Grabowski; Didisheim, Paul; Jc, Lewis; Jt, Franta; Jq, Stropp

doi:10.1097/00002480-197700230-00040

Cited by 94 publications

(31 citation statements)

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“…58 It is important to remember that species differences are biomaterial dependent, with the response of any given species significantly affected by the material being investigated. 59 Furthermore, laboratory measures of coagulation cannot be used in isolation to predict graft performance; for instance, canines demonstrate generally superior patency for ePTFE conduits compared with sheep despite shorter coagulation times in vitro. 44,60 Baboon.…”

Section: Comparative Hematologymentioning

confidence: 99%

Animal models for the assessment of novel vascular conduits

Byrom

Bannon

White

et al. 2010

Journal of Vascular Surgery

155

132

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The development of an ideal small-diameter conduit for use in vascular bypass surgery has yet to be achieved. The ongoing innovation in biomaterial design generates novel conduits that require preclinical assessment in vivo, and a number of animal models have been used for this purpose. This article examines the rationale behind animal models used in the assessment of small-diameter vascular conduits encompassing the commonly used species: baboons, sheep, pigs, dogs, rabbits, and rodents. Studies on the comparative hematology for these species relative to humans are summarized, and the hydrodynamic values for common implant locations are also compared. The large- and small-animal models are then explored, highlighting the characteristics of each that determine their relative utility in the assessment of vascular conduits. Where possible, the performance of expanded polytetrafluoroethylene is given in each animal and in each location to allow direct comparisons between species. New challenges in animal modeling are outlined for the assessment of tissue-engineered graft designs. Finally, recommendations are given for the selection of animal models for the assessment of future vascular conduits.

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Section: Comparative Hematologymentioning

confidence: 99%

Animal models for the assessment of novel vascular conduits

Byrom

Bannon

White

et al. 2010

Journal of Vascular Surgery

155

132

View full text Add to dashboard Cite

show abstract

“…This species difference brings to mind that between human and animal platelets with respect to adherence to foreign surfaces. Human platelets adhere poorly to certain biomaterials (7,8) and glass (unpublished observations), whereas rabbit and dog platelets adhere readily. It will be of interest to determine whether the present human-bovine species difference extends to cardiovascular biomaterials (e.g.…”

Section: Resultsmentioning

confidence: 82%

Human versus bovine endothelial cell culture on glass and tissue-culture plastic

Grabowski

McDonnell

1993

Journal of Tissue Culture Methods

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SUMMARY: This work demonstrates that human umbilical vein endothelial cells (HUVECs; Passages 1 and 5) attach to and grow on glass poorly in comparison to bovine aortic endothelial cells (BAECs; Passage 5). Seventeen hours after seeding passage 5 cells, there are 6.0 + 0.1 × 103 HUVECs/cm 2 (mean + SE, n = 12) on gelatin-coated glass, vs. 29.3 _+ 1.5 × 10 3 BAECs/cm 2. This poor attachment and growth is due to a dependence of HUVECs on surface charge and preadsorbed fibronectin not shared by BAECs, because both cell types proliferate on tissue culture plastic and HUVECs can be made to grow comparably well on gelatin-coated glass by the further addition of poly-L-lysine and fibronectin. These data indicate the existence of a human-bovine species difference with respect to endothelial celt adhesion to and growth on glass.

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“…Although the tissue reactivity of these animals to implants is largely similar, there are substantial quantitative and qualitative haemofolical differences between species, resulting in wide ranging thrombogenic response to artificial materials [37][38][39][40][41][42][43][44][45].…”

Section: Animal Modelmentioning

confidence: 99%

“…Further, this testing always has the limitation that haematologically, no animal corresponds exactly to man. For example, the platelets of the monkey, sheep and calf are much more resistant to aggregation with adenosine disphosphate (ADP), thrombin and collagen than human platelets, and pig platelets do not respond to ADP, even at a very high concentration [39][40][41][42]. The adhesion of dog platelets to some polymeric substrates is three times greater than those of the human [38].…”

Section: Animal Modelmentioning

confidence: 99%

Degradable, microporous vascular prosthesis from segmented polyurethane

Gogolewski

Galletti

1986

Colloid & Polymer Sci

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Abstract:. Small caliber (1.5 mm I. D.) vascular prostheses have been prepared from fractionated segmented polyurethane.The microporous and compliant prosthesis when implanted in the abdominal aorta of the rat, induced the growth of a neo-conduit, with a cellular structure similar to that of the natural artery. The process of growth of the neo-artery was accompanied by a progressive degradation of the prosthesis.

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Platelet Adhesion to Foreign Surfaces Under Controlled Conditions of Whole Blood Flow

Cited by 94 publications

References 0 publications

Animal models for the assessment of novel vascular conduits

Animal models for the assessment of novel vascular conduits

Human versus bovine endothelial cell culture on glass and tissue-culture plastic

Degradable, microporous vascular prosthesis from segmented polyurethane

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