Degradable, microporous vascular prosthesis from segmented polyurethane

Gogolewski, S; Galletti, G

doi:10.1007/bf01410635

Cited by 29 publications

(11 citation statements)

References 18 publications

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“…The potential of various synthetic degradable scaffolds used alone or seeded with cells to support the regeneration of body organs and tissues primarily in the cardiovascular system of experimental animals was extensively investigated in the early 1980s. [2][3][4][5][6] During the past decade, scaffolds from natural resorbable polymers such as collagen, gelatine, fibrin, and alginates, or synthetic resorbable polymers primarily polyhydroxyacids such as polyglycolide, polylactides, and copolymers of glycolide with lactides have been extensively tested for their capability to support the growth of chondrocytes harvested from various animal species. Bovine chondrocytes cultured in gels from collagen type I isolated from rat tail tendon increased initially in number, but from day 6 onward, they dedifferentiated into fibroblast-like cells.…”

Section: Introductionmentioning

confidence: 99%

In vitro growth and activity of primary chondrocytes on a resorbable polylactide three-dimensional scaffold

Gugala

Gogolewski

2000

J. Biomed. Mater. Res.

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Sheep articular chondrocytes were cultured for 3, 6, and 9 weeks on a three-dimensional porous scaffold from poly(L/DL-lactide) 80/20%. Cell growth and activity was estimated from the amount of proteoglycans attached to the polylactide scaffold and the amounts of DNA and proteins measured in the cell lysate. Cell morphology was assessed from scanning electron microscopy. Histochemical staining of proteoglycans present in the sponge was used to visualize the chondrocyte ingrowth in the scaffold. The amounts of DNA, proteins, and proteoglycans increased with time of culturing. Chondrocytes on the polylactide scaffold maintained their round shape. The cell ingrowth into the sponge progressed with time of culturing and proceeded from the upper surface of the sponge toward its lower surface. At 9 weeks, the chondrocytes filled the whole scaffold and reached the opposite side of the sponge. The proteoglycans network was, however, more dense at the upper half of the scaffold.

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Section: Introductionmentioning

confidence: 99%

In vitro growth and activity of primary chondrocytes on a resorbable polylactide three-dimensional scaffold

Gugala

Gogolewski

2000

J. Biomed. Mater. Res.

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“…Degradable polyurethane vascular prostheses, when implanted in the abdominal aorta of the rat, induced neo-artery growth [10,11].…”

Section: Introductionmentioning

confidence: 99%

Polyurethane vascular prostheses in pigs

Gogolewski¹,

Galletti

Ussia

1987

Colloid & Polymer Sci

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Microporous, compliant vascular prostheses made from segmented polyurethanes of various molecular stability, have been implanted in the infrarenal aorta of young pigs. Prostheses prepared from a hydrolytically stable polyetherurethane showed a limited patency up to 1 month. Composke prostheses with the wall made from a hydrolyticaUy stable polyurethane and the lumen side prepared from a degradable polyurethane, were patent up to one year. A degradable layer of this composke prosthesis induced the growth of a neo-artery. Prostheses prepared from a degradable polyurethane alone, were substituted within 4 months wkh a functional neo-artery.

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“…The latter three polymers were used previously for the construction of vascular prostheses [13][14][15].…”

Section: Methodsmentioning

confidence: 99%

“…The aim of the present study was to establish whether some selected polyurethanes, previously used for the preparation of vascular prostheses [13][14][15], can also be utilized for construction of potential pericardial substitutes. In addition to stable polyurethanes, degradable polyurethane and/or polyurethane-polyhydroxyacid composites were also evaluated in order to determine whether the deliberate degradation of the pericardial substitute improves the healing pattern of the pericardium.…”

Section: Introductionmentioning

confidence: 99%

Polyurethane microporous membranes as pericardial substitutes

Gogolewski¹,

Walpoth

Rheiner³

1987

Colloid & Polymer Sci

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Pericardial substitutes were prepared from stable and degradable segmented polyurethanes and/or polyurethane/polyhydroxybutyrate composites.Polyurethane membranes implanted as pericardial substitute in the rabbit, did not activate adhesion and epicardial reaction over 3 months.Polyurethane/polyhydroxybutyrate membranes induced minimal adhesion or epicardial reaction, yet stimulated the growth of epithelium on the polymeric substrate and reduced the incidence of infection.

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Degradable, microporous vascular prosthesis from segmented polyurethane

Cited by 29 publications

References 18 publications

In vitro growth and activity of primary chondrocytes on a resorbable polylactide three-dimensional scaffold

In vitro growth and activity of primary chondrocytes on a resorbable polylactide three-dimensional scaffold

Polyurethane vascular prostheses in pigs

Polyurethane microporous membranes as pericardial substitutes

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