Platelet a granule release in diabetes mellitus

Sacchi, Stefano; Curci, G; Piccinini, L; Cucci, F.; Messerotti, Andrea; Roncaia, R; Benedetti, P.

doi:10.3109/00365518509160990

Cited by 18 publications

(7 citation statements)

References 7 publications

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“…But insulin administration has normalized platelet activity to PGI 2 in coronary heart diseases both in vitro and in vivo [115, 116]. Vitamin E deficiency plays a crucial role in platelet aggregation, where α -tocopherol supplementation in response to ADP decreases TxA 2 [117].…”

Section: Platelet Dysfunction In Cardiovascular Disorder (Cvd) Andmentioning

confidence: 99%

Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis

Ghoshal

Bhattacharyya

2014

The Scientific World Journal

269

219

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Platelets are small anucleate cell fragments that circulate in blood playing crucial role in managing vascular integrity and regulating hemostasis. Platelets are also involved in the fundamental biological process of chronic inflammation associated with disease pathology. Platelet indices like mean platelets volume (MPV), platelets distributed width (PDW), and platelet crit (PCT) are useful as cheap noninvasive biomarkers for assessing the diseased states. Dynamic platelets bear distinct morphology, where α and dense granule are actively involved in secretion of molecules like GPIIb , IIIa, fibrinogen, vWf, catecholamines, serotonin, calcium, ATP, ADP, and so forth, which are involved in aggregation. Differential expressions of surface receptors like CD36, CD41, CD61 and so forth have also been quantitated in several diseases. Platelet clinical research faces challenges due to the vulnerable nature of platelet structure functions and lack of accurate assay techniques. But recent advancement in flow cytometry inputs huge progress in the field of platelets study. Platelets activation and dysfunction have been implicated in diabetes, renal diseases, tumorigenesis, Alzheimer's, and CVD. In conclusion, this paper elucidates that platelets are not that innocent as they keep showing and thus numerous novel platelet biomarkers are upcoming very soon in the field of clinical research which can be important for predicting and diagnosing disease state.

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Section: Platelet Dysfunction In Cardiovascular Disorder (Cvd) Andmentioning

confidence: 99%

Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis

Ghoshal

Bhattacharyya

2014

The Scientific World Journal

269

219

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“…In diabetic patients, elevation of levels of (3-thromboglobulin and platelet factor 4 released from a-granules of platelets when platelets are activated has also been described (10)(11)(12)(13). Recently, enhanced biosynthesis of thromboxane in platelets, which enhances thrombotic tendency (14), has been reported.…”

Section: Platelet Function In Diabetic Patientsmentioning

confidence: 99%

Mechanism on Disorders of Coagulation and Fibrinolysis in Diabetes

Matsuda

Morishita²,

Jokaji³

et al. 1996

Diabetes

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Determination of various important parameters of coagulation and fibrinolysis, clinical characteristics, and levels of serum lipid were compared in 193 patients with NIDDM and 50 control subjects. Levels of fibrinogen, tissue factor pathway inhibitor (TFPI), thrombin-anti-thrombin complex, and plasminogen activator inhibitor 1 in plasma increased significantly in the diabetic patients. Levels of TFPI correlated significantly with levels of total cholesterol. In the patients with coronary heart disease or cerebral infarction, levels of lipoprotein(a) increased significantly. From these results, we have concluded that there is a thrombotic tendency or at least an imbalance between the hemostatic and thrombosis-protecting system in diabetic patients, especially in patients with angiopathy.

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“…Changes in the regulation of the arachidonic acid metab- olism resulting in increased proaggregatory thromboxane formation were reported [2,3,8,11], but could not be confirmed recently for type I diabetics with or without retinopa thy [12], a-Granule proteins such as 0-thromboglobulin ((3-TG) and platelet factor 4 (PF-4) are released during platelet activa tion [13]. Plasmatic concentrations of these proteins were found to be increased in dia betics [3,[14][15][16][17][18], reflecting a higher degree o f'in vivo' platelet activation. This has been shown for patients without microangiopathy and even more for newly diagnosed type I diabetics [19,20].…”

Section: Introductionmentioning

confidence: 99%

Elevated Platelet Activation in Type I Diabetics with Chronic Complications under Long-Term Near-Normoglycemic Control

Tschöepe

Ostermann²,

Huebinger³

et al. 1990

Pathophysiol Haemos Thromb

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A prethrombotic state with altered, hyperactive platelets may contribute to the development of diabetic late complications. Whether increased platelet ‘in vivo’ activation can be reduced by tight metabolic control is controversial. We studied plasma markers of platelet activation in 64 long-term, microangiopathic type I diabetics after at least 18 months of intensive treatment for near-normoglycemia. Both platelet factor 4 and β-thromboglobulin proved to be significantly (p ≤ 0.05) elevated in comparison with healthy controls: 15.8 (sdf 2)/77.6 (sdf 1.9) vs. 8.9 (sdf 1.6)/45.1 (sdf 2) ng/ml (sdf = standard deviation factor). We found no significant correlations with any metabolic parameter (actual blood glucose, mean blood glucose, HbA 1 triglycerides, cholesterol) or with the duration of intensive treatment. It is therefore concluded, that platelet ‘in vivo’ activation takes place in type I diabetics even after long-term near-normoglycemic control. This deviation could be regarded as indicator of an additional risk for the development of vascular complications.

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Platelet a granule release in diabetes mellitus

Cited by 18 publications

References 7 publications

Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis

Overview of Platelet Physiology: Its Hemostatic and Nonhemostatic Role in Disease Pathogenesis

Mechanism on Disorders of Coagulation and Fibrinolysis in Diabetes

Elevated Platelet Activation in Type I Diabetics with Chronic Complications under Long-Term Near-Normoglycemic Control

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