Plasticizer concentration and the performance of a diffusion-controlled polymeric drug delivery system

Chamarthy, Sai Prasanth; Pinal, Rodolfo

doi:10.1016/j.colsurfa.2008.05.047

Cited by 69 publications

(33 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The plant based polymers have been studied various research group for their application in different pharmaceutical dosage forms like matrix controlled system, film coating agents, buccal films, microspheres, nanoparticles, viscous liquid formulations like ophthalmic solutions, suspensions, implants and their efficacy have been reported (Pandey, Khuller, 2004;Chamarthy, Pinal, 2008;Alonso-Sande et al, 2009). These have also been utilized as viscosity enhancers, stabilizers, disintegrants, solubilisers, emulsifiers, suspending agents, gelling agents and bioadhesives, binders in the above mentioned dosage forms (Guo,et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Physico-chemical and structural characterization of mucilage isolated from seeds of Diospyros melonoxylon Roxb.

Singh¹,

Bothara²

2014

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

Mucilage was isolated from the seeds of Diospyros melonoxylonRoxb., a plant growing naturally in the forests of India. Various physico-chemical methods like particle analysis, scanning electron microscopy, differential scanning calorimetry, differential thermal analysis, thermogravimetry analysis, molecular weight by gel permeation chromatography, rheometry, elemental analysis, x-ray diffraction spectrometry, zeta potential, fourier transform infrared spectroscopy, 1D(1H and 13C) (NMR) have been employed to characterize this gum in the present study. Particle analyses suggest that mucilage had particle size in nanometer. SEM analysis suggested that the mucilage had irregular particle size. The glass transition temperature of the gum observed was 78 °C and 74 °C by DSC and DTA respectively. The Thermogravimetry analysis suggested that mucilage had good thermal stability with two stage decomposition. The molecular weight of mucilage was determined to be 8760, by gel permeation chromatography, while the viscosity of mucilage was observed to be 219.1 cP. The XRD pattern of the mucilage indicated a complete amorphous nature. Elemental analysis of the gum revealed specific contents of carbon, hydrogen, nitrogen and sulfur. The major functional groups identified from FT-IR spectrum include 3441 cm-1 (-OH), 1632 cm-1 (-COO-), 1414 cm-1 (-COO-) and 1219 cm-1 (-CH3CO). Analysis of mucilage by paper chromatography and 1D NMR indicated the presence of sugars.

show abstract

Section: Introductionmentioning

confidence: 99%

Physico-chemical and structural characterization of mucilage isolated from seeds of Diospyros melonoxylon Roxb.

Singh¹,

Bothara²

2014

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

show abstract

“…For example, a serious case of patients generating an immune response to an essential natural human protein, recombinant human erythropoietin (EPO), has led to studies that focus on the potential leaching of chemicals from rubber stoppers of pre-filled syringes (Casadevall et al 2005). There is also the expectation that an interaction may occur with the final drug delivery format itself, for example any change in plasticizing effects due to competing actions of formulation components will lead to unpredictability in a controlled dosing technique (Chamarthy et al 2008). It is also critical to ensure a stable formulation when including a high loading of nanoparticulates, as is often the case in pharmaceutical printing.…”

Section: Ancillary Equipmentmentioning

confidence: 99%

Inkjet printing for pharmaceutics – A review of research and manufacturing

Daly

Harrington

Martin

et al. 2015

International Journal of Pharmaceutics

263

185

View full text Add to dashboard Cite

Abstract:Global regulatory, manufacturing and consumer trends are driving a need for change in current pharmaceutical sector business models, with a specific focus on the inherently expensive research costs, high-risk capital-intensive scale-up and the traditional centralised batch manufacturing paradigm. New technologies, such as inkjet printing, are being explored to radically transform pharmaceutical production processing and the end-to-end supply chain. This review provides a brief summary of inkjet printing technologies and their current applications in manufacturing before examining the business context driving the exploration of inkjet printing in the pharmaceutical sector. We then examine the trends reported in the literature for pharmaceutical printing, followed by the scientific considerations and challenges facing the adoption of this technology. We demonstrate that research activities are highly diverse, targeting a broad range of pharmaceutical types and printing systems. To mitigate this complexity we show that by categorising findings in terms of targeted business models and Active Pharmaceutical Ingredient (API) chemistry we have a more coherent approach to comparing research findings and can drive efficient translation of a chosen drug to inkjet manufacturing.

show abstract

“…Modified release includes delayed release, extended release (prolonged, sustained), and pulsatile release (Chamarthy & Pinal, 2008).…”

Section: Drug Release Influenced By Plasticizersmentioning

confidence: 99%

“…The theophylline release profile from soluble starch plasticized with sorbitol exhibits two valleys, which can be explained as a simultaneous plasticizing effect of water penetrating from the dissolution medium and the antiplasticizing effect of sorbitol contained in the formulation (Chamarthy & Pinal, 2008).…”

Section: Effect Of Plasticizer Concentration On Drug Releasementioning

confidence: 99%