“…Recently published papers dealing with electrospun oral drug delivery systems reported similar productivities (Nagy et al, 2010Verreck et al, 2003;Brewster et al, 2004,b;Yu et al, 2013a,b;Vrbata et al, 2013;Wagner et al, 2011;Balogh et al, 2014;Li et al, 2013b;Williams et al, 2012;Ignatious et al, 2010). High speed electrospinning (HSES) combines electrostatic (Lukas et al, 2008) and high speed rotational (Sebe et al, 2013) jet generation and fiber elongation, thus improving the productivity significantly (Table 1).…”
Section: Comparison Of Technological Aspects (Snes Hses Sd)mentioning
confidence: 86%
“…Such nanofibers proved to be valuable in the fields of filtration , composites , textiles, catalysts , medicine anti-counterfeiting (Huang et al, 2010) and medical researches (wound dressing (Rosic et al, 2013), wound healing (Macri et al, 2012;Pelipenko et al, 2013), topical therapy (Huang et al, 2012a(Huang et al, ,b, 2014Nagy et al, 2014) and tissue engineering Driscoll et al, 2013;Nagy et al, 2013)). Electrospinning technology has recently attracted an increased academic and industrial attention because it is an effective way to prepare nanofibrous drug formulations with an enhanced dissolution (Verreck et al, 2003;Brewster et al, 2004;Nagy et al, 2010,c;Yu et al, 2013a,b,c,c;Vrbata et al, 2013;Wagner et al, 2011;Balogh et al, 2014;Li et al, 2013b;Williams et al, 2012;Yan et al, 2014) by combining a number of strategies and approaches. These include increasing the specific surface area; forming nano-amorphous solid dispersion (NASD); enhancing wettability and solubility; achieving supersaturation and hindering precipitation .…”
“…Recently published papers dealing with electrospun oral drug delivery systems reported similar productivities (Nagy et al, 2010Verreck et al, 2003;Brewster et al, 2004,b;Yu et al, 2013a,b;Vrbata et al, 2013;Wagner et al, 2011;Balogh et al, 2014;Li et al, 2013b;Williams et al, 2012;Ignatious et al, 2010). High speed electrospinning (HSES) combines electrostatic (Lukas et al, 2008) and high speed rotational (Sebe et al, 2013) jet generation and fiber elongation, thus improving the productivity significantly (Table 1).…”
Section: Comparison Of Technological Aspects (Snes Hses Sd)mentioning
confidence: 86%
“…Such nanofibers proved to be valuable in the fields of filtration , composites , textiles, catalysts , medicine anti-counterfeiting (Huang et al, 2010) and medical researches (wound dressing (Rosic et al, 2013), wound healing (Macri et al, 2012;Pelipenko et al, 2013), topical therapy (Huang et al, 2012a(Huang et al, ,b, 2014Nagy et al, 2014) and tissue engineering Driscoll et al, 2013;Nagy et al, 2013)). Electrospinning technology has recently attracted an increased academic and industrial attention because it is an effective way to prepare nanofibrous drug formulations with an enhanced dissolution (Verreck et al, 2003;Brewster et al, 2004;Nagy et al, 2010,c;Yu et al, 2013a,b,c,c;Vrbata et al, 2013;Wagner et al, 2011;Balogh et al, 2014;Li et al, 2013b;Williams et al, 2012;Yan et al, 2014) by combining a number of strategies and approaches. These include increasing the specific surface area; forming nano-amorphous solid dispersion (NASD); enhancing wettability and solubility; achieving supersaturation and hindering precipitation .…”
“…relatively lower temperature and mechanical activity) compared to temperature-based and mechanical-based methods make them more flexible in terms of selecting the best compound and excipient, as long as both components are miscible and soluble in the solvent system used. However, more stringent criteria are required for temperature-based methods, including criteria for the T g and the T m of both the compound and the excipient, the viscosity of the excipient, the miscibility of the components, the extrudability of the mixture, and the potential degradation of the compound on exposure to high temperature during the process (74,76,103,109,129,138,150,155,175). These could limit the applicability and use of temperature-based methods in the preparation and study of amorphous formulations.Fig.…”
Section: Current Status Of Research On Amorphous Formulationsmentioning
confidence: 99%
“…The temperatures ranged from 2°C to 60°C and the relative humidity varied between 0% and 100%. The duration also varied significantly, with stability studies lasting from 24 h to two years (73,74,81,82,84,86,88,92,93,104,105,109,110,113,115,116,118,120,123,124,126,127,129,130,132,134,135,139,143,146,149,153,158,166,169,172,175,176). While most of the studies did not mention the container used for the physical stability test, a few specified, for example, whether a closed or open container was used (88,92,113,123,132,146).…”
Section: Current Status Of Research On Amorphous Formulationsmentioning
The alarming numbers of poorly soluble discovery compounds have centered the efforts towards finding strategies to improve the solubility. One of the attractive approaches to enhance solubility is via amorphization despite the stability issue associated with it. Although the number of amorphous-based research reports has increased tremendously after year 2000, little is known on the current research practice in designing amorphous formulation and how it has changed after the concept of solid dispersion was first introduced decades ago. In this review we try to answer the following questions: What model compounds and excipients have been used in amorphous-based research? How were these two components selected and prepared? What methods have been used to assess the performance of amorphous formulation? What methodology have evolved and/or been standardized since amorphous-based formulation was first introduced and to what extent have we embraced on new methods? Is the extent of research mirrored in the number of marketed amorphous drug products? We have summarized the history and evolution of amorphous formulation and discuss the current status of amorphous formulation-related research practice. We also explore the potential uses of old experimental methods and how they can be used in tandem with computational tools in designing amorphous formulation more efficiently than the traditional trial-and-error approach.
“…These nanofiber webs can have several applications, including medical [1][2][3], pharmaceutical [4,5], sensor [6], filtering [7][8][9], clothing, construction engineering applications as well as composites [10,11]. Nanofibers have unique properties such as high surface to mass ratio and flexibility that makes possible to use them as reinforcement of composites.…”
Abstract. The present paper investigates how the presence of nanofiber interleaves affects the compressibility of the layup during manufacturing of the composites and hence determining the theoretically attainable fiber volume fraction at the given processing pressure. The results show that up to the interleave areal density of 10 g/m 2 per nanofiber layer the decrease of fiber volume fraction does not exceed 3% for a laminate of carbon fiber woven fabric. Interleaves inside a fabric laminate are more compressible than a plain electrospun veil. It can be explained as the nanofibers penetrate between the carbon fibers when applying compression during composite manufacturing. It can be stated that there is a strong interference between the interleaves and the carbon reinforcement, which can lead to effective toughness improvement of the composite without significant alteration of fiber volume content.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
