Plasticenta: First evidence of microplastics in human placenta

Ragusa, Antonio; Svelato, Alessandro; Santacroce, Costantino; Catalano, Piera; Notarstefano, Valentina; Carnevali, Oliana; Papa, Fabrizio; Rongioletti, Mauro; Baiocco, F.; Draghi, Simonetta; D’Amore, Elisabetta; Rinaldo, Denise; Matta, Maria; Giorgini, Elisabetta

doi:10.1016/j.envint.2020.106274

Cited by 1,647 publications

(855 citation statements)

References 32 publications

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“…It is therefore key that hazard characteristics of these textile microfibers are studied in more detail, in addition to exposure levels in indoor environments. A limitation here is the detection of microplastics, as smaller particles might escape current detection methods (10,76).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, we need to gather more information about exposure levels in indoor environments to assess real-life inhalation levels. A limitation here is the detection of microplastics, as smaller particles might escape current detection methods ( 10, 74 ). Especially our finding that epithelial differentiation and repair mechanisms are affected most by microplastics exposure, suggests airborne microplastics may be most harmful to young children with developing airways and to people undergoing high levels of epithelial repair.…”

Section: Discussionmentioning

confidence: 99%

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Inhalable textile microplastic fibers impair lung repair

Dijk

Song

Eck

et al. 2021

Preprint

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Synthetic textiles shed fibers that accumulate indoors and this results in continuous exposure when indoors. High exposure to microplastic fibers in nylon flock workers has been linked to the development of airway and interstitial lung disease, but the exact health effects of microplastic fibers on the lungs are unknown. Here we determined effects of polyester and nylon textile microplastic fibers on airway and alveolar epithelial cells using human and murine lung organoids. We observed that particularly nylon microfibers had a negative impact on the growth and development of airway organoids. We demonstrated that this effect was mediated by components leaking from nylon. Moreover, our data suggested that microplastic textile fibers may especially harm the developing airways or airways undergoing repair. Our results call for a need to assess exposure and inhalation levels in indoor environments to accurately determine the actual risk of these fibers to human health.TeaserAirborne fibers shed from synthetic textiles, in particular nylon, can inhibit repair of the cells coating the airways

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Inhalable textile microplastic fibers impair lung repair

Dijk

Song

Eck

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…They were discovered on peak of Everest (Napper et al 2020 ) and at the depths of the deep ocean (Zhang et al 2020a ; Courtene-Jones et al 2020 ). In humans, existence of microplastics in human stool (Schwabl et al 2019 ) and for the first time MP fragments in human placenta (Ragusa et al 2021 ) were confirmed.…”

Section: Current Studies On Microplastic Pollutionmentioning

confidence: 93%

“…Presence of microplastics in tap water (Tong et al 2020), sea salt (Selvam et al 2020), and bottled water (Mason et al 2018) are proven studies on how many ways they can reach the human body. Recent studies of microplastics in human stool (Zhang et al 2021) and placenta (Ragusa et al 2021) are examples of its presence in humans. If plastics can harm humans so badly, then what happens when we consume such minute particles which are even more dangerous still needs to be studied.…”

Section: Introductionmentioning

confidence: 99%

Effect of microplastics in water and aquatic systems

Issac

Kandasubramanian

2021

Environ Sci Pollut Res

440

100

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Graphical abstract Surging dismissal of plastics into water resources results in the splintered debris generating microscopic particles called microplastics. The reduced size of microplastic makes it easier for intake by aquatic organisms resulting in amassing of noxious wastes, thereby disturbing their physiological functions. Microplastics are abundantly available and exhibit high propensity for interrelating with the ecosystem thereby disrupting the biogenic flora and fauna. About 71% of the earth surface is occupied by oceans, which holds 97% of the earth’s water. The remaining 3% is present as water in ponds, streams, glaciers, ice caps, and as water vapor in the atmosphere. Microplastics can accumulate harmful pollutants from the surroundings thereby acting as transport vectors; and simultaneously can leach out chemicals (additives). Plastics in marine undergo splintering and shriveling to form micro/nanoparticles owing to the mechanical and photochemical processes accelerated by waves and sunlight, respectively. Microplastics differ in color and density, considering the type of polymers, and are generally classified according to their origins, i.e., primary and secondary. About 54.5% of microplastics floating in the ocean are polyethylene, and 16.5% are polypropylene, and the rest includes polyvinyl chloride, polystyrene, polyester, and polyamides. Polyethylene and polypropylene due to its lower density in comparison with marine water floats and affect the oceanic surfaces while materials having higher density sink affecting seafloor. The effects of plastic debris in the water and aquatic systems from various literature and on how COVID-19 has become a reason for microplastic pollution are reviewed in this paper.

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“…On the other side, plastic in agricultural J o u r n a l P r e -p r o o f soils poses a risk for drinking water supplies (Wanner, 2021). The first evidence of microplastic in human placenta was reported recently (Ragusa et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases

et al. 2021

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Plasticenta: First evidence of microplastics in human placenta

Cited by 1,647 publications

References 32 publications

Inhalable textile microplastic fibers impair lung repair

Inhalable textile microplastic fibers impair lung repair

Effect of microplastics in water and aquatic systems

Synthesis and characterization of polyethylene terephthalate (PET) precursors and potential degradation products: Toxicity study and application in discovery of novel PETases

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