Plasmonic Sensors for Monitoring Biological and Chemical Threat Agents

Saylan, Yeşeren; Akgönüllü, Semra; Deni̇zli̇, Adil

doi:10.3390/bios10100142

Cited by 43 publications

(30 citation statements)

References 97 publications

(138 reference statements)

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“…Localized surface plasmon resonance (LSPR)-based sensors have been widely used in various research fields such as biology, environment, and clinical research 11 – 13 . LSPR occurs at the nano-sized metal structures owing to the isolated electronic oscillation 14 .…”

Section: Introductionmentioning

confidence: 99%

Nanoplasmonic immunosensor for the detection of SCG2, a candidate serum biomarker for the early diagnosis of neurodevelopmental disorder

Lim

Sung

Jo³

et al. 2021

Sci Rep

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The neural circuits of the infant brain are rapidly established near 6 months of age, but neurodevelopmental disorders can be diagnosed only at the age of 2–3 years using existing diagnostic methods. Early diagnosis is very important to alleviate life-long disability in patients through appropriate early intervention, and it is imperative to develop new diagnostic methods for early detection of neurodevelopmental disorders. We examined the serum level of secretogranin II (SCG2) in pediatric patients to evaluate its potential role as a biomarker for neurodevelopmental disorders. A plasmonic immunosensor performing an enzyme-linked immunosorbent assay (ELISA) on a gold nanodot array was developed to detect SCG2 in small volumes of serum. This nanoplasmonic immunosensor combined with tyramide signal amplification was highly sensitive to detect SCG2 in only 5 μL serum samples. The analysis using the nanoplasmonic immunosensor revealed higher serum SCG2 levels in pediatric patients with developmental delay than in the control group. Overexpression or knockdown of SCG2 in hippocampal neurons significantly attenuated dendritic arborization and synaptic formation. These results suggest that dysregulated SCG2 expression impairs neural development. In conclusion, we developed a highly sensitive nanoplasmonic immunosensor to detect serum SCG2, a candidate biomarker for the early diagnosis of neurodevelopmental disorders.

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Section: Introductionmentioning

confidence: 99%

Nanoplasmonic immunosensor for the detection of SCG2, a candidate serum biomarker for the early diagnosis of neurodevelopmental disorder

Lim

Sung

Jo³

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The test result is usually not provided to the patient until the next day with such methods ( Figure 1 ). As a result, decentralized testing as a point-of-care (PoC) concept is critical for the timely and accurate detection of such diseases [ 38 , 39 , 40 ] and any conditions that require further downstream studies [ 41 , 42 , 43 , 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Biosensors as Nano-Analytical Tools for COVID-19 Detection

Pradhan

Lahare

Sinha

et al. 2021

Sensors

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Selective, sensitive and affordable techniques to detect disease and underlying health issues have been developed recently. Biosensors as nanoanalytical tools have taken a front seat in this context. Nanotechnology-enabled progress in the health sector has aided in disease and pandemic management at a very early stage efficiently. This report reflects the state-of-the-art of nanobiosensor-based virus detection technology in terms of their detection methods, targets, limits of detection, range, sensitivity, assay time, etc. The article effectively summarizes the challenges with traditional technologies and newly emerging biosensors, including the nanotechnology-based detection kit for COVID-19; optically enhanced technology; and electrochemical, smart and wearable enabled nanobiosensors. The less explored but crucial piezoelectric nanobiosensor and the reverse transcription-loop mediated isothermal amplification (RT-LAMP)-based biosensor are also discussed here. The article could be of significance to researchers and doctors dedicated to developing potent, versatile biosensors for the rapid identification of COVID-19. This kind of report is needed for selecting suitable treatments and to avert epidemics.

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“…Light scattering by assemblies of nanoparticles underpins many important applications of advanced nanomaterials, notably in the realm of optical sensing, [1][2][3][4] spectroscopy, [5][6][7][8] nanooptics, [9][10][11] and light-harvesting technologies. 12 It is also key to their characterisation.…”

Section: Introductionmentioning

confidence: 99%