Plasmonic Optical Fiber-Grating Immunosensing: A Review

Guo, Tuan; González-Vila, Álvaro; Loyez, Médéric; Caucheteur, Christophe

doi:10.3390/s17122732

Cited by 109 publications

(83 citation statements)

References 143 publications

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“…This feature makes TFBG a self-referenced system in strain and temperature for refractive index measurements. Sensitivity to SRI can be significantly improved through the excitation of surface plasmon resonance (SPR) [12,19,21,29]. An SPR is an oscillation of electrons at a metal-dielectric interface.…”

Section: Introductionmentioning

confidence: 99%

Multimodal plasmonic optical fiber grating aptasensor

et al. 2020

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Tilted fiber Bragg gratings (TFBGs) are now a well-established technology in the scientific literature, bringing numerous advantages, especially for biodetection. Significant sensitivity improvements are achieved by exciting plasmon waves on their metal-coated surface. Nowadays, a large part of advances in this topic relies on new strategies aimed at providing sensitivity enhancements. In this work, TFBGs are produced in both single-mode and multimode telecommunication-grade optical fibers, and their relative performances are evaluated for refractometry and biosensing purposes. TFBGs are biofunctionalized with aptamers oriented against HER2 (Human Epidermal Growth Factor Receptor-2), a relevant protein biomarker for breast cancer diagnosis. In vitro assays confirm that the sensing performances of TFBGs in multimode fiber are higher or identical to those of their counterparts in single-mode fiber, respectively, when bulk refractometry or surface biosensing is considered. These observations are confirmed by numerical simulations. TFBGs in multimode fiber bring valuable practical assets, featuring a reduced spectral bandwidth for improved multiplexing possibilities enabling the detection of several biomarkers.

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Section: Introductionmentioning

confidence: 99%

Multimodal plasmonic optical fiber grating aptasensor

et al. 2020

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“…MOFs can either be divided into two main categories depending on their structure, hollow-core MOFs (HC-MOFs) and solid-core MOFs or distinguished depending on their light guidance principles ( Figure 3). Among the different structures of OFSs and related microstructures [23], sensors based on geometry-modified fibers (D-shaped, polished, etched, and tapered) [20,[24][25][26], grating-assisted fibers [27][28][29], and MOF [30,31] represent three of the most widely developed OFS groups (Figure 2).…”

Section: Microstructured Optical Fiber-based Optical Sensorsmentioning

confidence: 99%

Functionalized Microstructured Optical Fibers: Materials, Methods, Applications

et al. 2020

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Microstructured optical fiber-based sensors (MOF) have been widely developed finding numerous applications in various fields of photonics, biotechnology, and medicine. High sensitivity to the refractive index variation, arising from the strong interaction between a guided mode and an analyte in the test, makes MOF-based sensors ideal candidates for chemical and biochemical analysis of solutions with small volume and low concentration. Here, we review the modern techniques used for the modification of the fiber’s structure, which leads to an enhanced detection sensitivity, as well as the surface functionalization processes used for selective adsorption of target molecules. Novel functionalized MOF-based devices possessing these unique properties, emphasize the potential applications for fiber optics in the field of modern biophotonics, such as remote sensing, thermography, refractometric measurements of biological liquids, detection of cancer proteins, and concentration analysis. In this work, we discuss the approaches used for the functionalization of MOFs, with a focus on potential applications of the produced structures.

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“…The effective refractive index of the cladding is determined by the indices of the core, the cladding and the surrounding medium [9]. In comparison with Fiber Bragg Gratings (FBG) in sub-micron grating period, which couples the forward propagating mode to the backward counterpropagating mode within the fiber core, LPFG sensors have the unique capability of monitoring the change in ambient 3 of 17 refractive index with extended applications in chemical, environmental, biological and other related fields [10][11][12][13][14].…”

Section: Long Period Fiber Gratings (Lpfg) Sensormentioning

confidence: 99%

Corrosion-Induced Mass Loss Measurement under Strain Conditions through Gr/AgNW-Based, Fe-C Coated LPFG Sensors

Guo

Fan

Chen

2020

Sensors

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In this study, graphene/silver nanowire (Gr/AgNW)-based, Fe-C coated long period fiber gratings (LPFG) sensors were tested up to 72 hours in 3.5 w.t% NaCl solution for corrosion-induced mass loss measurement under four strain levels: 0, 500, 1000 and 1500 µε. The crack and interfacial bonding behaviors of laminate Fe-C and Gr/AgNW layer structures were characterized using Scanning Electron Microscopy (SEM) and electrical resistance measurement. Both optical transmission spectra and electrical impedance spectroscopy (EIS) data were simultaneously measured from each sensor. Under increasing strains, transverse cracks appeared first and were followed by longitudinal cracks on the laminate layer structures. The spacing of transverse cracks and the length of longitudinal cracks were determined by the bond strength at the weak Fe-C and Gr/AgNW interface. During corrosion tests, the shift in resonant wavelength of the Fe-C coated LPFG sensors resulted from the effects of the Fe-C layer thinning and the NaCl solution penetration through cracks on the evanescent field surrounding the LPFG sensors. Compared with the zero-strained sensor, the strain-induced cracks on the laminate layer structures initially increased and then decreased the shift in resonant wavelength in two main stages of the Fe-C corrosion process. In each corrosion stage, the Fe-C mass loss was linearly related to the shift in resonant wavelength under zero strain and with the applied strain taken into account in general cases. The general correlation equation was validated at 700 and 1200 µε to a maximum error of 2.5% in comparison with 46.5% from the zero-strain correlation equation.

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Plasmonic Optical Fiber-Grating Immunosensing: A Review

Cited by 109 publications

References 143 publications

Multimodal plasmonic optical fiber grating aptasensor

Multimodal plasmonic optical fiber grating aptasensor

Functionalized Microstructured Optical Fibers: Materials, Methods, Applications

Corrosion-Induced Mass Loss Measurement under Strain Conditions through Gr/AgNW-Based, Fe-C Coated LPFG Sensors

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