Plasmonic nanomaterials for biodiagnostics

Howes, Philip D.; Rana, Subinoy; Stevens, Molly M.

doi:10.1039/c3cs60346f

Cited by 285 publications

(226 citation statements)

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“…Energy transfer between QDs and proximal donors or acceptors can be extremely efficient, and they can be functionalized with large numbers and varieties of functional molecules, factors that are vital for QD biosensors (3). Plasmonic nanoparticles exhibit unique optical properties due to LSPR (4). AuNPs receive particular attention because of their stability and ease of synthesis.…”

mentioning

confidence: 99%

Colloidal nanoparticles as advanced biological sensors

Howes

Chandrawati

Stevens

2014

Science

894

686

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Colloidal nanoparticle biosensors have received intense scientific attention and offer promising applications in both research and medicine. We review the state of the art in nanoparticle development, surface chemistry, and biosensing mechanisms, discussing how a range of technologies are contributing toward commercial and clinical translation. Recent examples of success include the ultrasensitive detection of cancer biomarkers in human serum and in vivo sensing of methyl mercury. We identify five key materials challenges, including the development of robust mass-scale nanoparticle synthesis methods, and five broader challenges, including the use of simulations and bioinformatics-driven experimental approaches for predictive modeling of biosensor performance. The resultant generation of nanoparticle biosensors will form the basis of high-performance analytical assays, effective multiplexed intracellular sensors, and sophisticated in vivo probes.Evolution has given rise to organisms of staggering complexity. Our now extensive knowledge of biological systems pales in comparison to the remaining mysteries. Unraveling these requires tools that probe the molecular machinery of life and provide detailed feedback on complex networks of subtle interactions. Such tools are cornerstones of biomedical research and practice, and improvements in these lead directly to a better understanding of fundamental biology, monitoring of health, and diagnosis of disease. Colloidal nanoparticle biosensors are a class of biological probe that will not only yield improved biological sensing but also provide a step change in our ability to probe the biomolecular realm. Nanoparticles can act as high-performance sensors because nanomaterials exhibit unique and useful behaviors not present in their bulk form: for example, bright tunable fluorescence from semiconductor nanoparticles and localized surface plasmon resonance (LSPR) phenomena in metallic nanoparticles. These particles exhibit intense responses to incident light (or other stimuli), and the ability to modulate this response by interaction with target analytes makes them excellent biosensor signal transducers. Outputs can be quantitative or qualitative depending on the functionality of

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confidence: 99%

Colloidal nanoparticles as advanced biological sensors

Howes

Chandrawati

Stevens

2014

Science

894

686

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“…Metal nanoparticles (such as gold and silver) show many interesting optical, electronic, and chemical properties, which can be used in a range of applications involving photography, catalysis, biological sensors, and drug delivery 26, 27, 28, 29, 30, 31. For example, metal nanoparticles can be used as structural building blocks to construct more complex objects in a bottom‐up fashion, holding promise for nanoelectronics and nanorobotics applications 32, 33.…”

Section: Introductionmentioning

confidence: 99%

Observation of Metal Nanoparticles for Acoustic Manipulation

et al. 2017

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Use of acoustic trapping for the manipulation of objects is invaluable to many applications from cellular subdivision to biological assays. Despite remarkable progress in a wide size range, the precise acoustic manipulation of 0D nanoparticles where all the structural dimensions are much smaller than the acoustic wavelength is still present challenges. This study reports on the observation of metal nanoparticles with different nanostructures for acoustic manipulation. Results for the first time exhibit that the hollow nanostructures play more important factor than size in the nanoscale acoustic manipulation. The acoustic levitation and swarm aggregations of the metal nanoparticles can be easily realized at low energy and clinically acceptable acoustic frequency by hollowing their nanostructures. In addition, the behaviors of swarm aggregations can be flexibly regulated by the applied voltage and frequency. This study anticipates that the strategy based on the unique properties of the metal hollow nanostructures and the manipulation method will be highly desirable for many applications.

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“…However, in order to make the leap from bench to body, further analysis must be completed in physiologically representative media, clinical samples and in vivo. [52] While diagnostic information can be extracted using chemometrics clinicians require simple yes/no answers to dispense a diagnosis or prognosis. Therefore, any transition to a clinical environment will require coupling of the data collection and analysis so that single definitive answers can be provided.…”

Section: Raman Spectroscopy and Ex Vivo/in Vivo Applications For The mentioning

confidence: 99%

Surface enhanced Raman spectroscopy (SERS): Potential applications for disease detection and treatment

McAughtrie

Faulds

Graham

2014

Journal of Photochemistry and Photobiology C: Photochemistry Re

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This version is available at https://strathprints.strath.ac.uk/49189/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the +44 (0) Highlights: A range of diseases can be detected by Raman and SERS in vitro, ex vivo and in vivo  In vivo multiplexed detection of cancer was achieved  SERS is also a key step in disease treatment  Studies must be further extended to a physiologically relevant medium and in vivo  The potential exists for the application of the techniques in a clinical setting

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Plasmonic nanomaterials for biodiagnostics

Cited by 285 publications

References 50 publications

Colloidal nanoparticles as advanced biological sensors

Colloidal nanoparticles as advanced biological sensors

Observation of Metal Nanoparticles for Acoustic Manipulation

Surface enhanced Raman spectroscopy (SERS): Potential applications for disease detection and treatment

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