Plasmonic nano-arrays for ultrasensitive bio-sensing

Abstract

Surface plasmon resonance (SPR) and localized SPR (LSPR) effects have been shown as the principles of some highlysensitive sensors in recent decades. Due to the advances in nano-fabrication technology, the plasmon nano-array sensors based on SPR and LSPR phenomena have been widely used in chemical and bioloical analysis. Sensing with surface-enhanced field and sensing for refractive index changes are able to identify the analytes quantitatively and qualitatively. With the newly developed ultrasensitive plasmonic biosensors, platforms with excellent performance have been built for various biomedical applications, including point-of-care diagnosis and personalized medicine. In addition, flexible integration of plasmonics nano-arrays and combining them with electrochemical sensing have significantly enlarged the application scenarios of the plasmonic nano-array sensors, as well as improved the sensing accuracy.

One-step rapid quantification of SARS-CoV-2 virus particles via low-cost nanoplasmonic sensors in generic microplate reader and point-of-care device

“…The detection technique of one-step rapid quantification of the SARS-CoV-2 pseudovirus was based on a label-free LSPR biosensor with extraordinary optical transmission (EOT) effect( Ebbesen et al, 1998 ; Hu et al, 2018 ; Jiang et al, 2018 ). EOT phenomenon is attributed to the strong field-enhanced plasma excitation in the vicinity of the nanoarrays induced by grating coupling of light at normal incidence illumination, which can simplify optical systems design and generate a high sensitivity to minute local refractive index changes( Ebbesen et al, 1998 ; Najiminaini et al, 2012 ).…”

Fabrication and Characterization of a Metallic–Dielectric Nanorod Array by Nanosphere Lithography for Plasmonic Sensing Application

“…The measured sensitivities are also shown in the inset of the figure, and these results are remarkably higher than those of previous reported experimental works [43][44][45][64][65][66][67]. In addition, Table S2 (see Supplemental Material) also shows the comparison of sensing performance for different reported plasmonic nanosensors in the literature [68][69][70][71][72][73][74][75][76]. The sensitivity indicates the change in the peak wavelength of the absorbance spectrum versus the change in the refractive index of the dropped liquid.…”

Magnetic Particles: Their Applications from Sample Preparations to Biosensing Platforms

“…The rapid and widespread advancement of SPR technology has been done by using magnetic materials for the intensity of the sensitivity of reflected light at a specific angle called the resonant angle [70]. The changing color of the solution can be observed due to the change in reflectance angle or wavelength against time in SPR system [71,72]. Immunoassays with SPR devices have been successfully developed to detect the extracellular vesicles by using antibodies against CD81 [73].…”