2011
DOI: 10.1021/nn2034204
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Plasmonic Mach–Zehnder Interferometer for Ultrasensitive On-Chip Biosensing

Abstract: We experimentally demonstrate a plasmonic Mach-Zehnder interferometer (MZI) integrated with a microfluidic chip for ultrasensitive optical biosensing. The MZI is formed by patterning two parallel nanoslits in a thin metal film, and the sensor monitors the phase difference, induced by surface biomolecular adsorptions, between surface plasmon waves propagating on top and bottom surfaces of the metal film. The combination of a nanoplasmonic architecture and sensitive interferometric techniques in this compact sen… Show more

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Cited by 155 publications
(131 citation statements)
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References 52 publications
(112 reference statements)
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“…In a finite one, on the other hand, part of the leaked waves will be reflected back to the interface and contribute more to the SLG absorption. The dominant effect in photoresponse, however, remains in the Au/air SPP, as inferred by the Fourier amplitudes in Figs.3b-e, and confirmed by the absorp- Besides photodetection, SPP+incident wave interference in a MGM architecture also lends itself to labelfree surface plasmon biosensing [68][69][70][71], whereby SLG assumes the role of an integrated transducer providing direct electrical readout, thus eliminating the need for optical measurements. The use of SLG as an integrated transducer was reported in a dielectric waveguide sensor geometry [72], but not in surface plasmon sensing.…”
mentioning
confidence: 57%
“…In a finite one, on the other hand, part of the leaked waves will be reflected back to the interface and contribute more to the SLG absorption. The dominant effect in photoresponse, however, remains in the Au/air SPP, as inferred by the Fourier amplitudes in Figs.3b-e, and confirmed by the absorp- Besides photodetection, SPP+incident wave interference in a MGM architecture also lends itself to labelfree surface plasmon biosensing [68][69][70][71], whereby SLG assumes the role of an integrated transducer providing direct electrical readout, thus eliminating the need for optical measurements. The use of SLG as an integrated transducer was reported in a dielectric waveguide sensor geometry [72], but not in surface plasmon sensing.…”
mentioning
confidence: 57%
“…The propagation constant exhibits roughly a linear dependence on the refractive index with a slope 1 1 23.76 rad m RIU s − − = ⋅µ ⋅ around 830 nm (RIU, refractive index unit). The slope increases with decreasing the wire cross section and represents the sensitivity to the index change which may find applications in plasmonic sensing [39]. We will later exploit such dependence of wavevector on the refractive index to control the emission of a nanoantenna.…”
Section: Waveguiding On a Single Nanowirementioning
confidence: 99%
“…However, their sensing capability is generally limited by the relatively low sensitivity, broad spectral linewidth and weak resonance intensity [10][11]. The reported refractive index (RI) sensitivities (detection limits) for these nanoplasmonic sensors are one to two orders of magnitude lower (larger) than those of typical prism-based sensing systems [12][13]. Another widely used nanoplasmonic sensing technique is SPP interferometry, which uses the phase-sensitive interference to control the linewidth of the interference pattern, which may improve the sensing resolution [14][15][16].…”
Section: Introductionmentioning
confidence: 99%