Plasmonic Core–Satellites Nanostructures with High Chirality and Bioproperty

Xu, Liguang; Hao, Changlong; Yin, Honghong; Liu, Liqiang; Ma, Wei; Wang, Libing; Kuang, Hua; Xu, Chuanlai

doi:10.1021/jz401014b

Cited by 41 publications

(39 citation statements)

References 54 publications

(67 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Electromagnetic hotspots formed by controlled aggregation or assembly of plasmonic nanostructures are known to be highly SERS-active. 22,46 In fact, it has been demonstrated that the contribution of a relatively small number of electromagnetic hotspots (63 out of 10 6 active sites) can be quite significant (∼25%) in the overall SERS signal, which underscores the importance of electromagnetic hotspots in the design of SERS probes. 47 Higher-magnification TEM images reveal sub-3 nm interstices that formed between the satellites on AuNS surface ( Figure 3A).…”

Section: Chemistry Of Materialsmentioning

confidence: 99%

Off-Resonant Gold Superstructures as Ultrabright Minimally Invasive Surface-Enhanced Raman Scattering (SERS) Probes

et al. 2015

View full text Add to dashboard Cite

Surface-enhanced Raman scattering (SERS) tags that serve as exogenous contrast agents for SERS-based bioimaging are comprised of size-and shape-controlled plasmonic nanostructures. For maximum SERS activity and image contrast, the localized surface plasmon resonance (LSPR) wavelength of SERS tags based on individual nanostructures must match with the excitation wavelength (typically in the near-infrared (NIR) therapeutic window, i.e., 650−900 nm). However, under the resonant excitation, these SERS tags typically exhibit very high photothermal conversion efficiency, resulting in excessive heat that can perturb or even damage the biological species being imaged. Here, we demonstrate bioenabled synthesis of a novel class of ultrabright SERS probes with built-in and accessible electromagnetic hotspots formed by densely packed satellite nanoparticles grown on a plasmonic core. Through the rational choice of the shape of the core, the LSPR wavelength of Au superstructures can be tuned to be either off-or on-resonant with the NIR excitation without sacrificing their high SERS activity. Consequently, the photothermal efficiency of these ultrabright SERS tags can be tuned to realize either contrast agents with minimal heating and perturbation or multifunctional theranostic agents that can image and photothermally kill the targeted cells.S urface-enhanced Raman scattering (SERS), which involves the large enhancement of Raman scattering from molecules adsorbed on (or in close proximity to) nanostructured metal surfaces, is emerging as a powerful bioimaging modality for image-guided interventions in intraoperative settings. 1−3 SERS offers numerous advantages such as ultrasensitivity, large multiplexing capability due to narrow line widths (∼2 nm), chemical specificity (quantized vibrational fingerprint of the Raman reporters), excellent photostability, absence of interference from water, and noninvasive near-infrared (NIR) excitation and emission, which enable deeper penetration into soft tissues. 4−8 Conventional SERS probe synthesis involves the adsorption of Raman reporters on size-and shape-controlled plasmonic nanostructures, followed by coating them with glass layers (such as silica or alumina) and modification with targeting ligands such as antibodies or aptamers for biological specificity. 9 It is known that the SERS enhancement from individual nanostructures is highly dependent on the relative positions of excitation wavelength and localized surface plasmon resonance (LSPR) wavelength of the plasmonic nanostructures employed as SERS medium. For maximum SERS enhancement, the LSPR wavelength of the nanostructures is shown to be λ λ λ λ ≈ + − LSPR ExcStokes Exc

show abstract

Section: Chemistry Of Materialsmentioning

confidence: 99%

Off-Resonant Gold Superstructures as Ultrabright Minimally Invasive Surface-Enhanced Raman Scattering (SERS) Probes

et al. 2015

View full text Add to dashboard Cite

show abstract

“…In our previous work, we found that, due to the dipole–dipole interaction between particles during the assembly of self‐assembled nanosuperstructures, a strong chiral signal is produced at the position of the surface plasmon resonance peak . Already described chiral superstructures include nanotweezers and nanotubes .…”

Section: Introductionmentioning

confidence: 99%

Chiral Shell Core–Satellite Nanostructures for Ultrasensitive Detection of Mycotoxin

Cai

Hao

Sun

et al. 2018

Small

Self Cite

View full text Add to dashboard Cite

Herein, the design of a DNA-based chiral biosensor is described utilizing the self-assembly of shell core-gold (Au) satellite nanostructures for the detection of mycotoxin, ochratoxin A (OTA). The assembly of core-satellite nanostructures based on OTA-aptamer binding exhibits a strong chiral signal with an intense circular dichroism (CD) peak. The integrity of the assembly of core-satellite nanostructures is limited to some extent in the presence of different levels of OTA. Correspondingly, the chiral intensity of assembly is weakened with increasing OTA concentrations, allowing quantitative determination of the target. The developed chiral sensor shows an excellent linear relationship between the CD signal and concentrations of OTA in the range of 0.1-5 pg mL with a limit of detection as low as 0.037 pg mL . The effectiveness of the biosensor in a sample of red wine is verified and a good recovery rate is obtained. These results suggest that the strategy has great potential for practical application.

show abstract

“…Strong chiroptical activity, together with unprecedented regulated intensities and peak positions, is not only vital for chiral plasmonic assemblies, but is urgently required for ultrasensitive and multivariable biosensing applications . Conventionally, adjusting the intensity is generally achieved by extensive synthesizing of building blocks of different sizes and myriad shapes and assembling these into a variety of predesigned chiral nanoscale assemblies, but the feasible fabrication of assemblies with tunable and strong chiroptical activity still poses great challenges …”

Section: Introductionmentioning

confidence: 99%

Shell‐Programmed Au Nanoparticle Heterodimers with Customized Chiroptical Activity

Zhao

et al. 2014

Small

Self Cite

View full text Add to dashboard Cite

Chiral plasmonic assemblies with strong and tunable chiroptical activity are emerging materials yet challenging to fabricate. Moreover, shell-programmed chiroptical regulation is really rare. Here, the chiroptical activity of core-shell (CS) nanoparticles (NPs) heterodimers (HDs) with different types and thicknesses of the shell but featuring the same gap was exploited. It was found that the type of shell guided the position of the chiral peaks, and the shell thickness tuned the intensity but also moderately affected the wavelength shift at invariable interparticle distance. Shell deposition intensified the hot-spot chirality, and evidently guided the enantiomorphous chiral configuration, resulting in a startlingly intense, asymmetric, dipolar coupling strength. The magnitude of the chiroptical activity showed an 8-10 fold enhancement with a maximum anisotropy factor (g-factor) of 1.5 × 10(-2) . Shell-driven chiroptical regulation opens new avenues to feasibly fabricate chiroptically active materials with desired chiroptical response for the development of switchable recognition units for sensitive and various target detections.

show abstract

Plasmonic Core–Satellites Nanostructures with High Chirality and Bioproperty

Cited by 41 publications

References 54 publications

Off-Resonant Gold Superstructures as Ultrabright Minimally Invasive Surface-Enhanced Raman Scattering (SERS) Probes

Off-Resonant Gold Superstructures as Ultrabright Minimally Invasive Surface-Enhanced Raman Scattering (SERS) Probes

Chiral Shell Core–Satellite Nanostructures for Ultrasensitive Detection of Mycotoxin

Shell‐Programmed Au Nanoparticle Heterodimers with Customized Chiroptical Activity

Contact Info

Product

Resources

About