Chiral Shell Core–Satellite Nanostructures for Ultrasensitive Detection of Mycotoxin

Cai, Jiarong; Hao, Changlong; Sun, Maozhong; Ma, Wei; Xu, Chuanlai; Kuang, Hua

doi:10.1002/smll.201703931

Cited by 63 publications

(51 citation statements)

References 59 publications

(70 reference statements)

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“…CD‐based sensing systems can also be based on the formation of more complicated Ag and Au nanomaterials, including trimer, tetramer, and polymer. Ochratoxin A (OTA) aptamer conjugated Ag core–Au shell nanoparticles (24.8 nm) and its complementary strand functionalized Au nanoparticles (15 nm) were used to fabricate satellite nanostructures for detecting OTA that is one of the most‐abundant food‐contaminating mycotoxins . Through DNA hybridization, the Au nanoparticles were anchored to Ag core–Au shell nanoparticles to form satellite nanostructures, leading to an intense CD peak at 521 nm.…”

Section: Sensing Applicationsmentioning

confidence: 99%

“…[26] Ligand exchange after synthesis Assembling nanoparticles into chiral strucutres Au-Ag heterodimer, [32] Au nanoparticle dimer, [45] Au nanorod dimer, [40c] Au double helice, [29] Au linear chain, [30] Ag nanoparticle chain, [37] side-by-side assemblies of Au nanorods, [31] polymers composed of Ag core-Au shell nanoparticles and Au nanoparticles. [50] for the preparation of chiral and achiral Au nanomaterials, respectively.…”

Section: Examples Of Chiral Nanomaterialsmentioning

confidence: 99%

“…Ochratoxin A (OTA) aptamer conjugated Ag core-Au shell nanoparticles (24.8 nm) and its complementary strand functionalized Au nanoparticles (15 nm) were used to fabricate satellite nanostructures for detecting OTA that is one of the most-abundant foodcontaminating mycotoxins. [50] Through DNA hybridization, the Au nanoparticles were anchored to Ag core-Au shell nanoparticles to form satellite nanostructures, leading to an intense CD peak at 521 nm. The aptamer interacts with OTA to form a certain conformation, leading to decreases in its hybridization with its complementary strand on the Au nanoparticle.…”

Section: Cd-based Sensing Systemsmentioning

confidence: 99%

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Chiral Ag and Au Nanomaterials Based Optical Approaches for Analytical Applications

Xü

Lin

2019

Part & Part Syst Charact

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Sensing of chiral compounds has gained great attentions for many decades. Chiral nanomaterials with a greater surface area, optical properties, and stability have however not been well realized in this field. Herein, strategies for the preparation of chiral Ag and Au nanomaterials are focused upon, including Ag and Au nanoparticles conjugated with chiral molecules with/without containing fluorophores, chiral nanoassemblies of Ag and Au nanoparticles, and chiral Ag and Au nanoclusters. The chirality of nanomaterials originates from their core and/or ligand, meanwhile that for nanoassemblies results from their complex spatial configuration. An emphasis is given to circular dichroism, colorimetry/UV–vis absorption, and fluorescence detection modes for sensing enantiomers and achiral analytes using the chiral Ag and Au nanomaterials. Several interesting examples for quantitation of DNA, proteins, peptides, drugs, and pollutants are provided to highlight their potential as sensitive and selective nanomaterials for enantiomer recognition and sensing of achiral analytes. Several important issues to be solved when using chiral nanomaterials for chiral recognition are specified. Some strategies for improving the sensitivity and selectivity of chiral nanomaterials for chiral recognition are suggested. The aim is to bring more attention to the potential of chiral nanomaterials for sensing important analytes such as chiral drugs.

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Section: Sensing Applicationsmentioning

confidence: 99%

Section: Examples Of Chiral Nanomaterialsmentioning

confidence: 99%

Section: Cd-based Sensing Systemsmentioning

confidence: 99%

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Chiral Ag and Au Nanomaterials Based Optical Approaches for Analytical Applications

Xü

Lin

2019

Part & Part Syst Charact

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“…When constructing chiral heterostructures, it is difficult to control nucleation and growth dynamics; [ 22 ] herein, site‐selective fabrication of asymmetric chiral Au heterocrystalline structures remains a significant challenge. In previous report, we and other group found that nanoscale chirality mainly originated from the chiral geometries of fabricated nanostructures, [ 23–32 ] and the chiral configuration was tunable by assembly time and molecular triggers. Once assembled, it is very difficult to tailor the wavelength of chiroptical bands unless changes are made to components of the assembled unit, or additional components are added by the postgrowth strategy, such as Ag or Au.…”

Section: Introductionmentioning

confidence: 99%

Chiral AuCuAu Heterogeneous Nanorods with Tailored Optical Activity

Wang

et al. 2020

Adv Funct Materials

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Here, a facile wet-chemistry route for the selective growth of crystalline copper (Cu) along the sides of gold nanorods (Au NRs) in the presence of a hexadecylamine (HDA) is reported. The resulting heterostructures feature part etching of copper by galvanic replacement reaction and form crystalline AuCu alloy metal on one side of the Au NRs. By virtue of the dipeptide (cysteine-phenylalanine, Cys-Phe) ligand used during synthesis, the AuCuAu heteronanorods (HNRs) exhibit strong circular dichroism (CD) in the wavelength range of 400-1000 nm. The plasmonic chirality can be tailored by increasing the length of the Au NRs, the scale of Cu nanocrystals on the Au NRs, and the amount of gold chloride for postgrowth, resulting in an anisotropy factor (g factor) as high as 0.57 × 10 −2 . The strong CD signals are attributed to the local electromagnetic field. Under circular polarized light (CPL) illumination, the chiral plasmonic AuCuAu nanostructure exhibits high efficiency for light polarization dependent reactive oxygen species ( 1 O 2 ) that is 22.31 times that of Au NRs. The results of this study demonstrate that the chiral enantiomer provides a chirality dependent avenue for highly efficient phototherapy.

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“…The selective responses of chiral nanoassemblies to external molecules have allowed their application in chiral configuration switching and as bio‐interacting components or substrates for biomonitoring, and in the development of various chirality‐based biosensors. We and others have developed chirality‐based biosensors for a range of small molecules (antibiotics, toxins, and chemicals), macromolecules (DNA and protein), and biomarkers in living cells (protein and microRNA). The combination of chirality‐, Raman‐, and fluorescence (multiple signal)‐based single or multitarget detection can lead to reliable and accurate monitoring of fine‐scale biological states.…”

Section: Introductionmentioning

confidence: 99%

Chirality‐Based Biosensors

Wang

et al. 2018

Adv Funct Materials

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109

120

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The fabrication of chiral nanostructures gives rise to characteristic chiroptical activity, which can be used for chirality-based biosensors. Great progress is made in the use of nanoassemblies for the construction of chiral nanoparticle dimers, pyramids, helices, and twisted structures, and their chiroptical activities correlate with diverse structural geometries and enantiomeric configurations. In DNA-hybridization-based chiral nanoassemblies, the assembly parameters, such as the components, gaps, multicomponents, and the aftergrowth of metal, can result in multiple bands and enhanced chiroptical effects. Based on known chiral nanostructures, the existing chiral nanoassembly-based biosensors together with their targets and signal amplification strategies are reviewed. Chirality involves multiple signals, and multitarget biosensors are introduced with newly developed chiral architectures for the accurate and reliable monitoring of biomarkers in living cells. The interactions between chiral nanoarchitectures and biosystems are also highlighted, which are important not only in the chiral dynamic switching of nano-objects for biomonitoring, but also in manipulating cell growth, proliferation, and adhesion. The future perspectives on chiral fabrication and its use in biosensors are also comprehensively discussed. and future perspectives in chiral fabrication to enhance the chiroptical properties for emerging biosensors application.

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Chiral Shell Core–Satellite Nanostructures for Ultrasensitive Detection of Mycotoxin

Cited by 63 publications

References 59 publications

Chiral Ag and Au Nanomaterials Based Optical Approaches for Analytical Applications

Chiral Ag and Au Nanomaterials Based Optical Approaches for Analytical Applications

Chiral AuCuAu Heterogeneous Nanorods with Tailored Optical Activity

Chirality‐Based Biosensors

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