Plasmodesmata Conductivity Regulation: A Mechanistic Model

Dorokhov, Yuri L.; Ershova, Natalia M.; Sheshukova, Ekaterina V.; Komarova, Tatiana V.

doi:10.3390/plants8120595

Cited by 25 publications

(28 citation statements)

References 134 publications

(221 reference statements)

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“…mRNA translation in vitro (Karpova et al, 1997;Karpova et al, 1999), we suggest that MP may interact with both viral and cellular mRNAs translated on ER-linked polyribosomes and participate in the inhibition of translation of messengers encoding proteins involved in the stress response and regulation of plasmodesmal permeability (Dorokhov et al, 2019;Ganusova and Burch-Smith, 2019).…”

Section: Possible Mechanisms Of Cell Conditioning To Facilitate the Imentioning

confidence: 96%

“…their influence indirectly by interacting with factors that then influence Pd conformation, such as callose (Amsbury et al, 2017) and Pd-associated proteins (PdAPs) (Dorokhov et al, 2019). Unlike many PdAPs, callose has been convincingly shown to negatively regulate the Pd aperture (Levy et al, 2007a;Zavaliev et al, 2011;Wu et al, 2018).…”

Section: Possible Mechanisms Of Cell Conditioning To Facilitate the Imentioning

confidence: 99%

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The Tobamoviral Movement Protein: A “Conditioner” to Create a Favorable Environment for Intercellular Spread of Infection

et al. 2020

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During their evolution, viruses acquired genes encoding movement protein(s) (MPs) that mediate the intracellular transport of viral genetic material to plasmodesmata (Pd) and initiate the mechanisms leading to the increase in plasmodesmal permeability. Although the current view on the role of the viral MPs was primarily formed through studies on tobacco mosaic virus (TMV), the function of its MP has not been fully elucidated. Given the intercellular movement of MPs independent of genomic viral RNA (vRNA), this characteristic may induce favorable conditions ahead of the infection front for the accelerated movement of the vRNA (i.e. the MP plays a role as a "conditioner" of viral intercellular spread). This idea is supported by (a) the synthesis of MP from genomic vRNA early in infection, (b) the Pd opening and the MP transfer to neighboring cells without formation of the viral replication complex (VRC), and (c) the MP-mediated movement of VRCs beyond the primary infected cell. Here, we will consider findings that favor the TMV MP as a "conditioner" of enhanced intercellular virus movement. In addition, we will discuss the mechanism by which TMV MP opens Pd for extraordinary transport of macromolecules. Although there is no evidence showing direct effects of TMV MP on Pd leading to their dilatation, recent findings indicate that MPs exert their influence indirectly by modulating Pd external and structural macromolecules such as callose and Pdassociated proteins. In explaining this phenomenon, we will propose a mechanism for TMV MP functioning as a conditioner for virus movement.

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Section: Possible Mechanisms Of Cell Conditioning To Facilitate the Imentioning

confidence: 96%

Section: Possible Mechanisms Of Cell Conditioning To Facilitate the Imentioning

confidence: 99%

The Tobamoviral Movement Protein: A “Conditioner” to Create a Favorable Environment for Intercellular Spread of Infection

et al. 2020

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“…2B ). Viruses often express the proteins that ensure virion motility by modifying channels to facilitate the transmission of the infection to a neighboring cell [ 20 ]. This is how a local infection of a plant takes place.…”

Section: The Most Significant Phytopathogensmentioning

confidence: 99%

“…This is how a local infection of a plant takes place. In order to infect an entire plant, a virus must enter its vascular system, where it then moves passively through the sieve tubes of the phloem with the flow of substances: this is how it can infect cells distant from the primary site of the infection [ 19 , 20 ].…”

Section: The Most Significant Phytopathogensmentioning

confidence: 99%

Infectious plant diseases: etiology, current status, problems and prospects in plant protection

et al. 2020

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In recent years, there has been an increase in the number of diseases caused by bacterial, fungal, and viral infections. Infections affect plants at different stages of agricultural production. Depending on weather conditions and the phytosanitary condition of crops, the prevalence of diseases can reach 7080% of the total plant population, and the yield can decrease in some cases down to 8098%. Plants have innate cellular immunity, but specific phytopathogens have an ability to evade that immunity. This article examined phytopathogens of viral, fungal, and bacterial nature and explored the concepts of modern plant protection, methods of chemical, biological, and agrotechnical control, as well as modern methods used for identifying phytopathogens.

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“…These inclusion bodies at structurally modified PDs may serve as docking and conducting structures coordinating different viral proteins in the intercellular movement of viral replication vesicles and virions. In addition, VPg also may positively influence cell-to-cell potyvirus movement inducing proteasome-mediated degradation of plant protein remorin, thus preventing formation of remorin-specific plasma membrane nanodomains, which reduce membrane plasticity, and subsequent PD closure [5] – [7] , [44] , [60] , [86] – [90] .…”

Section: Potyvirusesmentioning

confidence: 99%

Small hydrophobic viral proteins involved in intercellular movement of diverse plant virus genomes

Morozov

Solovyev

2020

AIMS Microbiology

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Most plant viruses code for movement proteins (MPs) targeting plasmodesmata to enable cell-to-cell and systemic spread in infected plants. Small membrane-embedded MPs have been first identified in two viral transport gene modules, triple gene block (TGB) coding for an RNA-binding helicase TGB1 and two small hydrophobic proteins TGB2 and TGB3 and double gene block (DGB) encoding two small polypeptides representing an RNA-binding protein and a membrane protein. These findings indicated that movement gene modules composed of two or more cistrons may encode the nucleic acid-binding protein and at least one membrane-bound movement protein. The same rule was revealed for small DNA-containing plant viruses, namely, viruses belonging to genus Mastrevirus (family Geminiviridae ) and the family Nanoviridae . In multi-component transport modules the nucleic acid-binding MP can be viral capsid protein(s), as in RNA-containing viruses of the families Closteroviridae and Potyviridae . However, membrane proteins are always found among MPs of these multicomponent viral transport systems. Moreover, it was found that small membrane MPs encoded by many viruses can be involved in coupling viral replication and cell-to-cell movement. Currently, the studies of evolutionary origin and functioning of small membrane MPs is regarded as an important pre-requisite for understanding of the evolution of the existing plant virus transport systems. This paper represents the first comprehensive review which describes the whole diversity of small membrane MPs and presents the current views on their role in plant virus movement.

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Plasmodesmata Conductivity Regulation: A Mechanistic Model

Cited by 25 publications

References 134 publications

The Tobamoviral Movement Protein: A “Conditioner” to Create a Favorable Environment for Intercellular Spread of Infection

The Tobamoviral Movement Protein: A “Conditioner” to Create a Favorable Environment for Intercellular Spread of Infection

Infectious plant diseases: etiology, current status, problems and prospects in plant protection

Small hydrophobic viral proteins involved in intercellular movement of diverse plant virus genomes

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