Plasmatic parameters of coagulation activation in thrombotic microangiopathy

Sagripanti, A; Carpi, Angelo; Baicchi, U; Morganti, Marina; Rosaia, B.; Nicolini, Andrea; Mittermayer, C

doi:10.1016/s0753-3322(96)89668-5

Cited by 14 publications

(8 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, profound DIC is a rare complication in the absence of placental abruption. The fall in anti‐thrombin levels seen in pre‐eclampsia is not found in TTP (Sagripanti et al , 1996) and may, therefore, be of diagnostic value.…”

Section: Pre‐eclampsiamentioning

confidence: 96%

“…However, schistocytes may be absent from the peripheral blood film in the first 24–48 h following clinical presentation. Routine coagulation profiles are usually normal (Monteagudo et al , 1991; Sagripanti et al , 1996; Rock et al , 1998), although slight increases in D‐dimer, fibrin degradation products and thrombin–anti‐thrombin complex (TAT) may be seen (Monteagudo et al , 1991; Sagripanti et al , 1996; Wada et al , 1998). Secondary DIC may, however, arise from prolonged tissue ischaemia and is an ominous prognostic indicator.…”

Section: Laboratory Features and Investigationmentioning

confidence: 99%

See 1 more Smart Citation

Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias

et al. 2003

View full text Add to dashboard Cite

Section: Pre‐eclampsiamentioning

confidence: 96%

Section: Laboratory Features and Investigationmentioning

confidence: 99%

Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias

et al. 2003

View full text Add to dashboard Cite

“…An acute‐phase response may contribute to a prothrombotic state (Munford 2001) as a result of endothelial perturbation, increased activity of blood coagulation and attenuated fibrinolysis. A prothrombotic state is reflected by the presence of increased concentrations of proteins like von Willebrand factor (vWF) and plasminogen activator inhibitor‐1 (PAI‐1), or protein cleavage products as prothrombin fragment 1+2 (F1+2) and D‐dimer (Sagripanti et al 1996). Indeed, elevated plasma levels of these markers have been associated with a higher risk for recurrent ischaemic events in patients with a history of coronary heart disease or ischaemic stroke (Lindgren et al 1996, Cote et al 2000, Danesh et al 2001, Lowe et al 2001, Barber et al 2004).…”

mentioning

confidence: 99%

Periodontitis is characterized by elevated PAI‐1 activity

Bizzarro

Velden

Heggeler

et al. 2007

J Clinic Periodontology

View full text Add to dashboard Cite

Objectives: Periodontitis is a chronic infectious disease and has been associated with cardiovascular diseases (CVD). We investigated whether plasma levels of markers of a prothrombotic state were elevated in patients with periodontitis in comparison with healthy controls. Materials and methods: Untreated patients with moderate (n=53) and severe periodontitis (n=38) and healthy controls (n=39) were recruited. Levels of von Willebrand factor (vWF), prothrombin fragment 1+2 (F1+2), plasminogen activator inhibitor‐1 (PAI‐1) activity and D‐dimer were measured as markers of a prothrombotic state. Results: The erythrocyte sedimentation rate (ESR), plasma C‐reactive protein (CRP) and leucocyte counts (WBC) were significantly higher in patients with periodontitis. No statistically significant difference was found among the three groups for vWF (p=0.264), F1+2 (p=0.295) and D‐dimer (p=0.572). However, PAI‐1 was clearly elevated in the severe periodontitis group (p=0.001), even after adjusting for potential confounding factors (padj=0.004). Moreover, more patients than controls were having vWF and PAI‐1 levels above the respective population medians. Conclusions: In periodontitis, elevated levels of PAI‐1 activity are observed compared with healthy controls. This may increase the potential for impaired fibrinolysis, a condition that results in a prothrombotic state. We suggest that this state, if left untreated, may contribute to an increased risk for CVD.

show abstract

“…Previous studies in native kidneys focused on PAI-1, a prothrombotic factor by at least two mechanisms: inhibition of fibrinolysis by inhibiting the tPA-and uPA-mediated activation of plasminogen to plasmin (9) and inactivation of activated protein C (10). Serum studies in HUS (11), TMA (12), and primary and bone marrow transplantYassociated TTP (13) have found elevated PAI-1 serum levels, whereas results in diarrhea-positive HUS were conflicting (14,15). Two tissuebased studies showed increased glomerular PAI-1 compared with normal controls (16) by immunofluorescence and later also by in situ hybridization (17).…”

Section: Discussionmentioning

confidence: 99%

Glomerular mRNA Expression of Prothrombotic and Antithrombotic Factors in Renal Transplants With Thrombotic Microangiopathy

Agustian

Bockmeyer²,

Modde³

et al. 2013

Transplantation

View full text Add to dashboard Cite

The glomerular capillary bed seems to contribute to all subtypes of rTx-TMA by down-regulation of the endothelial transcription factors KLF2 and KLF4, indicating dedifferentiation with subsequent up-regulation of PAI-1 and down-regulation of tPA, resulting in inhibition of local fibrinolysis. Decreased glomerular expression of ADAMTS13 and CD55 could be an additional pathway toward microthrombosis exclusively in HR-TMA.

show abstract

Plasmatic parameters of coagulation activation in thrombotic microangiopathy

Cited by 14 publications

References 17 publications

Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias

Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias

Periodontitis is characterized by elevated PAI‐1 activity

Glomerular mRNA Expression of Prothrombotic and Antithrombotic Factors in Renal Transplants With Thrombotic Microangiopathy

Contact Info

Product

Resources

About