Periodontitis is characterized by elevated PAI‐1 activity

Abstract

Objectives: Periodontitis is a chronic infectious disease and has been associated with cardiovascular diseases (CVD). We investigated whether plasma levels of markers of a prothrombotic state were elevated in patients with periodontitis in comparison with healthy controls. Materials and methods: Untreated patients with moderate (n=53) and severe periodontitis (n=38) and healthy controls (n=39) were recruited. Levels of von Willebrand factor (vWF), prothrombin fragment 1+2 (F1+2), plasminogen activator inhibitor‐1 (PAI‐1) activity and D‐dimer were measured as markers of a prothrombotic state. Results: The erythrocyte sedimentation rate (ESR), plasma C‐reactive protein (CRP) and leucocyte counts (WBC) were significantly higher in patients with periodontitis. No statistically significant difference was found among the three groups for vWF (p=0.264), F1+2 (p=0.295) and D‐dimer (p=0.572). However, PAI‐1 was clearly elevated in the severe periodontitis group (p=0.001), even after adjusting for potential confounding factors (padj=0.004). Moreover, more patients than controls were having vWF and PAI‐1 levels above the respective population medians. Conclusions: In periodontitis, elevated levels of PAI‐1 activity are observed compared with healthy controls. This may increase the potential for impaired fibrinolysis, a condition that results in a prothrombotic state. We suggest that this state, if left untreated, may contribute to an increased risk for CVD.

A 3′ UTR transition within DEFB1 is associated with chronic and aggressive periodontitis

“…The Dutch CP patient cohort is a collection of three study groups as previously described. [34][35][36] Inclusion criteria for the German and Dutch AgP patients were age at diagnosis p35 years and X2 teeth with X50% periodontal bone loss. A set of full-mouth dental radiographs or panorex was available for confirmative periodontal bone scoring.…”

Levels of C-Reactive Protein and Protein C in Periodontitis Patients with and without Cardiovascular Disease

“…Although periodontitis has a chronic nature, acute-phase elements are also a part of the innate immunity in periodontitis and confirm that, in periodontitis, a systemic inflammation is present [30,31] . There are a number of studies which compare periodontal infections and the systemic markers of inflammation, particularly CRP [32][33][34][35] . Bizzarro et al [35] compared the CRP levels of periodontitis patients to those of periodontally healthy patients and found a statistically significant difference.…”

“…There are a number of studies which compare periodontal infections and the systemic markers of inflammation, particularly CRP [32][33][34][35] . Bizzarro et al [35] compared the CRP levels of periodontitis patients to those of periodontally healthy patients and found a statistically significant difference. In agreement with Bizzarro et al [35] , most studies have shown a relationship between CRP and periodontal disease severity [34,36,37] .…”

“…Bizzarro et al [35] compared the CRP levels of periodontitis patients to those of periodontally healthy patients and found a statistically significant difference. In agreement with Bizzarro et al [35] , most studies have shown a relationship between CRP and periodontal disease severity [34,36,37] . On the contrary, there are some studies that have found no relationship between healthy and periodontitis patients [8,33] .…”

Os sanum in corpore sano : (een gezonde mond in een gezond lichaam)

“…Patiënten met parodontitis hebben hogere spiegels van PAI-1 (plasminogeen activator inhibitor-1), een molecuul dat de afbraak van een microthrombus remt (84). PAI-1 wordt beschouwd als een haemostatische factor die kan bijdragen aan de predispositie voor hart-en vaatziekten (85).…”