Plasmatic levels of interleukin-1ß and interleukin-6 in newborn infants with fever

Silveira, Rita de Cássia dos Santos; Procianoy, Renato Soibelmann

doi:10.2223/jped.253

Cited by 4 publications

(3 citation statements)

References 22 publications

(31 reference statements)

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“…In the newborn, the septic shock is predominantly cold and characterized by Although the systemic inflammatory response, characterized by tachycardia, tachypnea, hyperthermia and leukocytosis is more frequently triggered by infection, there are several systemic inflammatory response syndrome (SIRS) promoters during the immediate neonatal period as traumatic delivery, severe perinatal asphyxia, metabolism innate errors, surgical procedures, among other conditions also responsible for inflammatory mediators release, and these, through the pro-inflammatory events cascade, culminating in septic shock. [12][13][14][15][16][17] Early detection and reversal of shock improves rate of survival. 18 This could be one of the main reasons for high mortality in present study as most of patients presented in decompensated shock.…”

Section: Discussionmentioning

confidence: 99%

Clinical profile and short-term outcomes in neonates with septic shock

Sujana

Meshram

Lakhkar

2019

Int J Contemp Pediatr

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Background: Neonatal sepsis is a syndrome causing severe organ dysfunction triggered by a dysregulated host in response to an infection, affecting millions of neonates. In such situations, early identification and management in the initial hours dramatically improves the outcome. Hence, it was taken up to study the incidence, clinical profile and short-term outcomes of neonates with septic shock.Methods: Hospital based prospective observational study on 95 neonates admitted to neonatal intensive care unit in the department of Paediatrics at Acharya Vinobha Bhave rural hospital, Sawangi, Wardha from 1st August 2016 to 31st July 2018.Neonates diagnosed with septic refractory shock were enrolled after taking IEC approval and assent form and those with non-septic aetiology shock were excluded. Statistical analysis was done to establish correlation between neonatal variables and outcome.Results: 95 neonates fulfilled the inclusion criteria and were recruited. Out of these, 37 and 53 were outborn and inborn respectively. Maximum neonates were preterm and males. Neonates with birth weight 1000-1499 grams to those less than 1000 was 4.2:1. Normal vaginal delivery was more common as compared to lower segment caesarean section (LSCS). Blood culture positivity was in 44.2%. Age of presentation with shock ranged from 1 to 20 days and duration of shock ranged from 2 hours to 192 hours. Most infants were ventilated (84%) and it was more among those who died.Conclusions: Septic shock is the most common type, carrying high morbidity and mortality (more than 60%). Laboratory and clinical parameters (TLC, Platelet count, CRP, Blood culture, duration of shock, HR, RR, BP or arterial blood gas) (p>0.05) did not carry a prognostic value in predicting the outcome of such neonates. Early identification and intervention remains the key in managing such a challenging neonatal condition.

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Section: Discussionmentioning

confidence: 99%

Clinical profile and short-term outcomes in neonates with septic shock

Sujana

Meshram

Lakhkar

2019

Int J Contemp Pediatr

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“…Examinations of histological tissues have demonstrated that teething process is associated with a progressive inflammatory reaction in the periodontal tissue which causes soreness and swelling of the gums before tooth eruption (de França Landim et al, 2013). The fever occurring during teething is an integral part of the acute inflammatory reaction of teething process and is produced by cytokines (Shapira et al, 2003;Silveira & Procianoy, 1998). Cytokines are small protein signalling molecules, which are known to induce fever (Krause et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Teething induced fever in a 9-month old child: a case report

Dika

Iddi

Kayange

2018

Tanzania J Hlth Res

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The association between teething and fever has attracted considerable interest because studies have reported controversial results. These discordant results have posed a challenge in the management of fever occurring during teething. The objective of this paper is to supplement previous studies which showed association between teeth eruption and fever and highlight mismanagement of teething induced fever. A 9-month old baby girl presented with fever during teeth eruption. Despite of no malaria parasites seen on blood slide and lack of features and laboratory investigations suggestive of urinary tract infection or bacteremia, the child was treated with antimalarial drugs and prescribed antibiotics. This case study demonstrates that unrecognized teething induced fever leads to unnecessary use of anti-malarial drugs and antibiotics. We recommend paediatricians to consider teething as one of the causes of fever among children.

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“…1,4,[10][11][12] The fever response is considered an integral part of the acute inflammatory reaction and is produced by interleukin-1 (IL-1), which is an endogenous pyrogen that activates specialized receptors located in the hypothalamus. 13 IL-1 is produced by different cells, including macrophages, monocytes, osteoclasts, A cells, neutrophils, fibroblasts and epithelial cells [14][15][16][17] and is secreted in the extracellular fluid in two molecular forms, alpha and beta, both of which have proinflammatory effects. The main effects of IL-1 are to activate macrophages, stimulate the biosynthesis of prostaglandins by macrophages and fibroblasts, stimulate the synthesis of antibodies, be chemotactic for polymorphonuclear neutrophils, stimulate the synthesis of lymphokines by T lymphocytes, cause fever through the stimulus of hypothalamic cells and stimulate bone resorption.…”

Section: -9mentioning

confidence: 99%

Assessment of Gingival Mucosa of Infant Rats during Teething

Carvalho

et al. 2013

JCDP

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Aim:The aim of the present study was to perform a histological analysis of the gingival mucosa in infant rats undergoing the teething process. Materials and methods:Eighteen Wistar rats between 8 and 15 days of life were distributed among three groups: group A-without teething; group B-eruption of incisors; and group C-eruption of incisors and molars. The samples included teeth and periodontal tissue from the region of the incisors and molars of each animal. Fragments were processed for histological analysis and submitted to immunohistochemical analysis. Results:In the 8-day-old rats, mild inflammatory infiltrate predominated with mononuclear cells in the pericoronal follicles of the incisors and molars. At 12 days of age, all animals exhibited moderate inflammation in the pericoronal follicles and epithelium of the incisors and mild inflammatory infiltrate with predominantly mononuclear cells in the molars. At 15 days of age, moderate neutrophilic exudate was found in the pericoronal follicles and epithelium of the incisors and molars. Immunohistochemical analysis revealed positivity for interleukin1b in the pericoronal follicles in the pre-eruption phase. Conclusion:An inflammatory reaction with progressive intensity occurs during the teething process, the response of which is preceded by the release of interleukin-1b.Clinical significance: Morphological proof of events that occur during teething that can affect the dynamics of the physiologic process manifesting as clinical symptoms.

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Plasmatic levels of interleukin-1ß and interleukin-6 in newborn infants with fever

Cited by 4 publications

References 22 publications

Clinical profile and short-term outcomes in neonates with septic shock

Clinical profile and short-term outcomes in neonates with septic shock

Teething induced fever in a 9-month old child: a case report

Assessment of Gingival Mucosa of Infant Rats during Teething

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