Assessment of Gingival Mucosa of Infant Rats during Teething

Ev, Landim; Mg, de Carvalho; Carvalho, de; Granville-Garcia, Ana Flávia; F, Lima Rde; Em, de Brito Costa

doi:10.5005/jp-journals-10024-1441

Cited by 2 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a rat model [43], Landim et al investigated the gingival mucosa of infant rats at different days of postnatal life and showed an inflammatory reaction with progressive intensity that occurred during teething process, and was initiated by the release of IL-1β.…”

Section: Academic Journal Of Pediatrics and Neonatologymentioning

confidence: 99%

It's Alright, Ma (I'm only Teething...) Dispelling the Myth from the Teeth

Pollak¹

2017

AJPN

View full text Add to dashboard Cite

Historical perspectiveFrom time immemorial, teething has been blamed for all manner of childhood illnesses. References to teething pain appear as early as 3000 BC on Sumerian clay tablets. The Atharva Veda, a sacred Hindu text written around 1000 BC, included a prayer for the safe cutting of a child's teeth, and the Homeric hymns, dating from the ninth century BC, give mention to a "teething worm" [1]. The first known description of specific aspects of dentition may be found in the Indian treatise Kashyap Samhita [2]. Later texts, namely the AstangaSamgraha, written by the Ayurvedic scholar Vagbhata in the seventh century BC, list the symptoms and

show abstract

Section: Academic Journal Of Pediatrics and Neonatologymentioning

confidence: 99%

It's Alright, Ma (I'm only Teething...) Dispelling the Myth from the Teeth

Pollak¹

2017

AJPN

View full text Add to dashboard Cite

show abstract

Role of Innate Inflammation in the Regulation of Tissue Remodeling during Tooth Eruption

et al. 2021

View full text Add to dashboard Cite

Tooth eruption is characterized by a coordinated complex cascade of cellular and molecular events that promote tooth movement through the eruptive pathway. During tooth eruption, the stratum intermedium structurally changes to the papillary layer with tooth organ development. We previously reported intercellular adhesion molecule-1 (ICAM-1) expression on the papillary layer, which is the origin of the ICAM-1-positive junctional epithelium. ICAM-1 expression is induced by proinflammatory cytokines, including interleukin-1 and tumor necrosis factor. Inflammatory reactions induce tissue degradation. Therefore, this study aimed to examine whether inflammatory reactions are involved in tooth eruption. Reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed sequential expression of hypoxia-induced factor-1α, interleukin-1β, and chemotactic factors, including keratinocyte-derived chemokine (KC) and macrophage inflammatory protein-2 (MIP-2), during tooth eruption. Consistent with the RT-PCR results, immunohistochemical analysis revealed KC and MIP-2 expression in the papillary layer cells of the enamel organ from the ameloblast maturation stage. Moreover, there was massive macrophage and neutrophil infiltration in the connective tissue between the tooth organ and oral epithelium during tooth eruption. These findings suggest that inflammatory reactions might be involved in the degradation of tissue overlying the tooth organ. Further, these reactions might be induced by hypoxia in the tissue overlying the tooth organ, which results from decreased capillaries in the tissue. Our findings indicate that bacterial infections are not associated with the eruption process. Therefore, tooth eruption might be regulated by innate inflammatory mechanisms.

show abstract

Assessment of Gingival Mucosa of Infant Rats during Teething

Cited by 2 publications

References 22 publications

It's Alright, Ma (I'm only Teething...) Dispelling the Myth from the Teeth

It's Alright, Ma (I'm only Teething...) Dispelling the Myth from the Teeth

Role of Innate Inflammation in the Regulation of Tissue Remodeling during Tooth Eruption

Contact Info

Product

Resources

About