Plasmas for Treating Cancer: Opportunities for Adaptive and Self-Adaptive Approaches

Keidar, Michael; Beilis, I. I.; Trink, Barry; Sherman, Jonathan H.

doi:10.1016/j.tibtech.2017.06.013

Cited by 140 publications

(108 citation statements)

References 41 publications

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“…[1][2][3] Major applications of medical plasmas are wounds, skin-derived diseases and, as off-label use, palliation in cancer patients. [4][5][6][7][8][9][10][11][12] CAPs offer a well-documented efficacy in inactivating bacteria 13 that may contribute to the stimulation of wound healing processes. 14,15 Plasma treatment inuences cell or tissue physiology at various levels, including metabolism, signaling, and cell fate, leading to immunomodulation, angiogenesis, tissue proliferation, or migration.…”

Section: Introductionmentioning

confidence: 99%

On a heavy path – determining cold plasma-derived short-lived species chemistry using isotopic labelling

et al. 2020

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Section: Introductionmentioning

confidence: 99%

On a heavy path – determining cold plasma-derived short-lived species chemistry using isotopic labelling

et al. 2020

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“…This increase in reactive species is the main trigger that initiates tumour cell death. The specific responses here are apoptosis, growth inhibition, cell cycle arrest, DNA and mitochondrial damage, and even immunogenic cell death [110]. The actual result, however, is dose-dependent [111][112][113].…”

Section: Use Of Cap For Tumour Treatmentmentioning

confidence: 97%

Cold Atmospheric Plasma: A Powerful Tool for Modern Medicine

Braný

Dvorska

Halašová

et al. 2020

IJMS

186

138

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Cold atmospheric plasma use in clinical studies is mainly limited to the treatment of chronic wounds, but its application in a wide range of medical fields is now the goal of many analyses. It is therefore likely that its application spectrum will be expanded in the future. Cold atmospheric plasma has been shown to reduce microbial load without any known significant negative effects on healthy tissues, and this should enhance its possible application to any microbial infection site. It has also been shown to have anti-tumour effects. In addition, it acts proliferatively on stem cells and other cultivated cells, and the highly increased nitric oxide levels have a very important effect on this proliferation. Cold atmospheric plasma use may also have a beneficial effect on immunotherapy in cancer patients. Finally, it is possible that the use of plasma devices will not remain limited to surface structures, because current endeavours to develop sufficiently miniature microplasma devices could very likely lead to its application in subcutaneous and internal structures. This study summarises the available literature on cold plasma action mechanisms and analyses of its current in vivo and in vitro use, primarily in the fields of regenerative and dental medicine and oncology.

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“…Cold atmospheric plasma (CAP) is an incompletely ionized type of physical plasma (the fourth state of matters). It contains reactive oxygen and nitrogen species with speci c species being highly dependent on the gas used [5,6]. CAP has been widely applied in many bio-related elds such as bacterial disinfection, cell transfection, dentistry and wound healing [7][8][9][10][11], with its selectivity against cancer cells being rstly reported in 2007 [12].…”

Section: Introductionmentioning

confidence: 99%

Cold Atmospheric Plasma Selectively Induces G0/G1 Cell Cycle Arrest and Apoptosis in AR-Independent Prostate Cancer Cells

Meng

Zhang

et al. 2020

Preprint

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BackgroundAndrogen receptor-independent prostate cancers do not respond to androgen blockage therapies and suffer from high recurrence rate. We aim to contribute to the establishment of novel therapeutic approaches against such malignancies.Methods We examined whether and how cold atmospheric plasma delivers selectivity against AR-independent prostate cancers using human normal epithelial prostatic cells PNT1A and AR-negative DU145 prostate cancer cells.ResultsWe show that cold atmospheric plasma could selectively halt cell proliferation and migration in androgen receptor-independent cells as a result of induced cell apoptosis and G0/G1 stage cell cycle arrest, and such outcomes were achieved through modulations on the MAPK and NF-kB pathways in response to physical plasma induced intracellular redox level. ConclusionOur study reports cold atmospheric plasma induced reduction on the proliferation and migration of androgen receptor-independent prostate cancer cells that offers novel therapeutic insights on the treatment of such cancers, and provides the first evidence on physical plasma induced cell cycle G0/G1 stage arrest that warrants the exploration on the synergistic use of cold atmospheric plasma and drugs such as chemotherapies in eradicating such cancer cells.

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Plasmas for Treating Cancer: Opportunities for Adaptive and Self-Adaptive Approaches

Cited by 140 publications

References 41 publications

On a heavy path – determining cold plasma-derived short-lived species chemistry using isotopic labelling

On a heavy path – determining cold plasma-derived short-lived species chemistry using isotopic labelling

Cold Atmospheric Plasma: A Powerful Tool for Modern Medicine

Cold Atmospheric Plasma Selectively Induces G0/G1 Cell Cycle Arrest and Apoptosis in AR-Independent Prostate Cancer Cells

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