Plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma: case report

Romero, Ivana Lopes; Campos, Felipe Augusto Garcez de; Damasceno, Renato Wendell; Filho, José Vital; Bison, Simone Haber Duellberg Von Faber

doi:10.1590/s0004-27492009000200020

Cited by 10 publications

(7 citation statements)

References 10 publications

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“…Literature review identified a total of 111 previously reported cases in 68 articles regarding orbital involvement in patients with systemic MM (Table 2). 4,6-61…”

Section: Resultsmentioning

confidence: 99%

Orbital Involvement in Multiple Myeloma

Shoji

Chen

Topilow

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To characterize clinical and radiographic features, management, and outcomes of patients with orbital involvement of multiple myeloma (MM). Methods: A retrospective chart review identified patients with MM and orbital involvement confirmed by histopathology at a single institution between 1995 and 2021. A comprehensive literature review was performed via PubMed to identify all previously reported cases of orbital MM. Results: Retrospective review identified 7 patients (43% male, mean age 68.7 years). Presenting symptoms included proptosis and diplopia. Orbital lesions were primarily located laterally (42.8%) with associated extraocular muscle (57.1%) or lacrimal gland (42.9%) involvement. Five patients (71.4%) had a previous diagnosis of systemic MM. Six patients received chemoradiation (85.7%). All patients had improvement of orbital disease with 2 patients deceased due to disease at follow-up (mean 8.9 months). Literature review identified 111 cases (46.8% male, mean age 58.6 years). 48.6% presented with orbital disease as the first manifestation of systemic MM. Lesions were most commonly located superolaterally (20.2%) with extraocular muscle infiltration (25.2%), lacrimal gland involvement (7.2%), and orbital bony destruction (39.6%). Treatments included chemoradiation, chemotherapy, or radiation alone. Approximately half (51.4%) of patients experienced improvement in orbital disease following treatment, and 48.6% were deceased at follow-up (mean 20.1 months). Conclusions: This study provides a new retrospective study and updated comprehensive literature review regarding orbital MM. Given its poor prognosis, characterization of orbital MM is essential for early diagnosis. Orbital MM is often unilateral, located superolaterally, and may represent the first manifestation of systemic disease. Treatment includes chemotherapy and radiation, which may improve orbital disease; however, the overall prognosis remains poor.

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“…Literature review identified a total of 111 previously reported cases in 68 articles regarding orbital involvement in patients with systemic MM (Table 2). 4,6-61…”

Section: Resultsmentioning

confidence: 99%

Orbital Involvement in Multiple Myeloma

Shoji

Chen

Topilow

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…Since most plasmacytomas are not truly solitary; often the orbital component is the presenting sign for systemic disease. [ 5 ]…”

Section: Discussionmentioning

confidence: 99%

Masquerading solitary plasmacytoma; an eyelid lump in disguise

et al. 2021

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“…9,10 Romero et al described a case of SPB involving the lacrimal gland with secondary transformation into MM at 5 years. 9 Their case presented differently with progressive pain and bony involvement on computerized tomography. Agrawal et al described two cases of plasmacytoma involving the lacrimal gland.…”

Section: Discussionmentioning

confidence: 99%

Extramedullary plasmacytoma arising from the lacrimal gland

Sia

Cannon

Selva

2010

Clinical Exper Ophthalmology

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An 80-year-old man presented with an 8-week history of painless swelling in the right lacrimal gland region with infero-medial dystopia of the globe. The lesion was excised and histology confirmed an orbital plasmacytoma. Multiple myeloma screening was negative and a solitary extramedullary plasmacytoma arising from the lacrimal gland was diagnosed. The patient was subsequently treated with radiotherapy.

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Plasmacytoma of the orbit involving lacrimal gland with secondary transformation into multiple myeloma: case report

Cited by 10 publications

References 10 publications

Orbital Involvement in Multiple Myeloma

Orbital Involvement in Multiple Myeloma

Masquerading solitary plasmacytoma; an eyelid lump in disguise

Extramedullary plasmacytoma arising from the lacrimal gland

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