Plasmacytoma of the larynx diagnosed by fine‐needle aspiration cytology: A case report

Abstract

Extramedullary plasmacytoma is a rare lesion. The use of fine-needle aspiration for diagnosis of plasmacytoma has been described in a few sporadic reports. To the best of our knowledge, none of these reports described the cytologic findings from plasmacytoma of the larynx. We report on a case of laryngeal plasmacytoma in a 79-yr-old man diagnosed by fine-needle aspiration cytology. The patient had a history of a plasmacytoma involving the sixth thoracic vertebra diagnosed in 1996, which progressed to multiple myeloma in 1997. He received treatment in the form of local radiation to the skeletal vertebrae and chemotherapy. Two years later, the patient presented with a large neck mass. Computed tomography (CT) was done at an outside facility, and the radiologic impression was of a large right glottic carcinoma with invasion into the right thyroid cartilage. Because of the history of multiple myeloma, a fine-needle aspiration (FNA) biopsy was performed of the laryngeal mass. Cytologic examination demonstrated atypical plasma cells arranged in a dissociative fashion, consistent with a plasmacytoma. Although there are previous surgical pathology reports of laryngeal plasmacytoma, to the best of our knowledge, this is the first report of plasmacytoma of the larynx diagnosed by FNA cytology.

Solitary Extramedullary Plasmacytoma of the Thyroid Gland

“…Indeed, the differential diagnosis is not only with lymphoma but also with the medullary and undifferentiated carcinomas [6]. FNAC with research of monoclonal cells expressing kappa light chains allowed the diagnosis in rare cases [7]. One of the most difficult issues in the diagnosis of solitary plasmacytoma of the thyroid is to rule out a multiple myeloma.…”

Extramedullary plasmacytoma of thyroid - a mimicker of medullary carcinoma at fine needle aspiration cytology: A case report

“…[12] There are many reported cases of solitary plasmacytomas of the extrathyroidal sites diagnosed on fine needle aspiration cytology (FNAC) in literature. [34] A diagnosis of solitary plasmacytoma of the thyroid made during FNAC, however, to the best of our knowledge, is rare and unique. [4] The present case illustrates the difficulty in arriving at an FNAC diagnosis of solitary plasmacytoma of the thyroid, due to the presence of atypical Hurthle cells and the associated amyloid in the tumor.…”

A Case of Multiple Myeloma: Mimicking Carcinoma Larynx

“…EMP is typically presents as a welllocalized submucosal swelling, sometimes with polypoidal configuration. Presenting symptoms of EMP of head and neck are frequently secondary to local destruction and tumor mass [2,[6][7][8].…”