A Case of Multiple Myeloma: Mimicking Carcinoma Larynx

Nochikattil, Santhosh Kumar; Iype, Elizabeth Mathew; Ramrao, Surnare Kailash; Nair, P Sindhu; Thomas, Shaji

doi:10.1007/s12070-016-0987-z

Cited by 4 publications

(10 citation statements)

References 14 publications

(10 reference statements)

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“…El acúmulo de células plasmáticas monoclonales neoplásicas sin evidencia de patología sistémica se denomina plasmocitoma solitario, que se definirá como óseo o extramedular según se localice en la médula ósea o fuera de la misma. Es habitual la progresión de la forma solitaria a mieloma múltiple 2 , 4 , que es la diseminación sistémica de la enfermedad 2 , 4 .…”

Section: Discussionunclassified

“…La afectación laríngea es poco frecuente, suponiendo tan solo el 0,4% del total de cánceres laríngeos y menos de un 1% del total de los cánceres en cabeza y cuello 2 , 3 .…”

Section: Discussionunclassified

“…Los plasmocitomas son lesiones únicas, mientras que el mieloma múltiple es la forma sistémica de la enfermedad 1 - 5 . La afectación laríngea es poco frecuente, suponiendo menos del 1% de los tumores en esta localización 2 , 3 . Para el diagnóstico de la afectación cervical son necesarios un estudio cervical con tomografía computarizada (TAC) y la biopsia 5 , 6 .…”

Section: Introductionunclassified

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Multiple myeloma with laryngeal affectation: an uncommon cause of dysphonia

Fernández

Fuertes

Torres

et al. 2023

An Sist Sanit Navar

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Resumen Las neoplasias de células plasmáticas suponen un conjunto de enfermedades caracterizadas por la proliferación tumoral de dichas células en forma de lesión única (plasmocitoma) o enfermedad sistémica (mieloma). La afectación cartilaginosa laríngea es inusual y su manifestación clínica es similar a la de un carcinoma laríngeo. Describimos el caso de un paciente varón de 70 años con disfonía tras un diagnóstico reciente de mieloma múltiple. Después de realizar los estudios radiológico e inmunohistoquímico se diagnosticó la afectación laríngea por este tumor. Actualmente el paciente está siendo tratado con lenalidomida, dexametasona y bortezomib.

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Section: Discussionunclassified

“…La afectación laríngea es poco frecuente, suponiendo tan solo el 0,4% del total de cánceres laríngeos y menos de un 1% del total de los cánceres en cabeza y cuello 2 , 3 .…”

Section: Discussionunclassified

Section: Introductionunclassified

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Multiple myeloma with laryngeal affectation: an uncommon cause of dysphonia

Fernández

Fuertes

Torres

et al. 2023

An Sist Sanit Navar

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“…In two of the ten cases, a MM had been known in the patient's history [3, 22]. In four of the remaining eight cases, the pathologic clinical findings in the larynx led to the diagnosis of MM [20, 21, 25, 26]. In one of the remaining four cases, additionally to the findings in the larynx, there was a solitary plasmacytoma of the rib [24].…”

Section: Discussionmentioning

confidence: 99%

Rare Differential Diagnosis of Dyspnea: Extramedullary Plasmocytoma (EMP) of the Larynx—Case Report and Review of the Latest Literature of Laryngeal EMP and Laryngeal Involvement of Multiple Myeloma

Steinke

Schneider

Welkoborsky

2019

Case Reports in Otolaryngology

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Multiple myeloma (MM) of the larynx is extremely rare. It can be either a laryngeal manifestation of a general multiple myeloma or it can occur as a primary laryngeal mass, which is then called extramedullary plasmocytoma (EMP). We present the case of an 81-year-old male patient who was admitted for dyspnea. He had a history of multiple myeloma but was in complete remission since some years. Histological and immunohistological examination of tissue samples revealed an EMP. The patient was first treated by laser surgery in order to reduce the tumor mass and secure the airway. Afterwards, he was systematically treated by radiation therapy with 60 Gy, which achieved a good response and complete remission proven by control laryngoscopy and histological examination of tissue samples taken from the former tumor area three months after laser excision. The latest literature in the field is reviewed. There were only ten cases of EMP in the larynx or laryngeal involvement of MM published within the last five years (Pubmed was searched for “larynx,” “laryngeal” and “EMP,” “Extramedullary Myeloma,” “Multiple Myeloma,” and “MM”). Due to its rarity, there are currently no evidence-based therapeutic guidelines available. For their development, multicenter studies are required.

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“…In den letzten 10 Jahren wurden 7 Case Reports publiziert, die von einer extramedullären Infiltration des Larynx bei bekanntem Multiplem Myelom berichten [1,3,5,6,10,12,14]. Es erfolgte bei allen eine erfolgreich größenreduzierende Radiotherapie des laryngealen Befundes.…”

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