Plasmacytoma arising from a focus of chronic osteomyelitis. A case report.

Roger, Douglas J.; Bono, James V.; Singh, Jaswant

doi:10.2106/00004623-199274040-00018

Cited by 6 publications

(5 citation statements)

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“…It may be related to some focal immunogenetic modulation in response to previous chronic involvement with LCH. Interestingly, a parallel of sorts could be drawn here with reports of plasmacytoma arising in areas of chronic osteomyelitis [40]. Although previous radiation to the site may have played a role [41], given the extreme rarity of such an association with XRT, we believe that the background of LCH was likely a significant adjunct.…”

Section: Discussionsupporting

confidence: 68%

Solitary Plasmacytoma in the Setting of Langerhans Cell Histiocytosis

2002

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Langerhans cell histiocytosis (LCH) is an intriguing disorder characterized by the accumulation of specialized dendritic cells called Langerhans cells in several diverse tissues and body sites. It has been cited in numerous case reports to be associated with a wide variety of malignant neoplasms. Although many hypotheses have been suggested, the basis for such associations remains essentially unknown. We describe another association here that to our knowledge has not been reported thus far: a solitary plasmacytoma occurring at a site of previous involvement by LCH. This constitutes a new addition to the now fairly lengthy list of malignant neoplasms that have been reported to occur in the setting of LCH. The possible reasons for such an association are discussed along with a brief review of LCH.

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Section: Discussionsupporting

confidence: 68%

Solitary Plasmacytoma in the Setting of Langerhans Cell Histiocytosis

2002

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“…Discussion SCC is the most common type of malignant tumour that evolves at the site of chronic osteomyelitis [3,8,11]. Fibrosarcoma [1,9,12,13], myeloma [7], lymphoma [7,12], plasmacytoma [15] angiosarcoma [2,4,14,16], rhabdomyosarcoma [7], and malignant fibrous histiocytoma [4,6,10] also have been reported. The latency period is between 20 and 50 years [7,8,20].…”

Section: Resultsmentioning

confidence: 99%

Squamous cell carcinoma arising in chronic osteomyelitis

Sağlık

Arıkan

Altay

et al. 2001

International Orthopaedics (SICOT)

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Squamous cell carcinoma (SCC) is a rare but well-documented complication of chronic osteomyelitis. Between February 1991 and March 1999, 13 cases (12 men and one woman) of SCC arising in chronic osteomyelitis were diagnosed and treated in our clinic. Mean age was 56.5 (38-70) years. Twelve patients underwent amputation and one underwent limb salvage. Average follow-up was 56 (24-121) months. Among the 13 patients two died of the disease. Treatment of choice for these tumours has been amputation.Resume Carcinome cellulaire squameux est une complication d'ostéomyélite, peu fréquente, mais bien connue. Entre le février 91-mars 99, dans notre clinique, nous ont constate 13 malades (12 hommes et 1 femme) a qui nous ont vu la maladie développe a la base d'ostéomyélite chronique. L'age moyen était 56.5. (38-70) 12 malades ont subi une amputation et dans l'autre l'extrémité a été gardée. La surveillance a duré à peu près 56 (24-121) mois. Parmi ces 13 malades seulement deux sont morts. Pour ces tumeurs on peut dire que l'amputation est la méthode la plus efficace.

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“…Moreover, in 1984, Parsons [ 16 ] described the case of a 68-year-old man with chronic osteomyelitis (40 years) diagnosed with solitary myeloma presenting as a lower femoral fracture. Finally, Roger [ 17 ] reported a 42-year-old man with chronic osteomyelitis presenting with a pathological fracture in the femur; this patient suffered trauma from an accident 20 years prior, and postoperative histopathology results from the tissue around the fracture were used to diagnose SBP. To our knowledge, we are reporting the seventh case of SBP with chronic osteomyelitis (Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

“…Author Age (yr) Sex Site Osteomyelitis history Symptoms 1 Loeper [12] (1947) 30 Male Femur 27 yr Sinus tract 2 Heilmann [13] (1957) 66 Male Both femora UN Paget disease characteristics 3 Baitz [14] (1964) UN UN femur 40 yr Sinus tract 4 Wohlenber [15] (1970) UN UN UN UN UN 5 Parsons [16] (1984) 68 Male Femur 40 yr Sinus and ulcer on the lateral thigh 6 Roger [17] (1992)…”

Section: Case Nomentioning

confidence: 99%

Solitary bone plasmacytoma of the tibia presenting as chronic osteomyelitis: A rare case report and literature review

et al. 2023

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Rationale: Plasmacytoma is a rare plasma cell dyscrasia that grows within the axial skeleton or soft tissue structures as solitary or multiple masses. The primary types are solitary plasmacytoma, including solitary bone plasmacytoma (SBP) and solitary extramedullary plasmacytoma, and multiple solitary plasmacytomas. SBP is characterized by localized proliferation of monoclonal plasma cells and is rare. However, SBP with chronic osteomyelitis is even rarer. Patient concerns: A 47-year-old man previously diagnosed with chronic osteomyelitis presented with repeated discharge and ulceration in the front of his right tibia. Diagnosis, interventions and outcomes: Lower extremity magnetic resonance imaging (MRI) and computed tomography (CT) examinations showed dead bone formation and surrounding inflammatory edema. Thus, the patient underwent dead bone excision and fenestration of the bone marrow cavity. The histopathologic examination results indicated plasmacytoma. Therefore, we administered radiotherapy with satisfactory results. Lessons: Physicians should pay close attention to chronic osteomyelitis because it may be accompanied by plasmacytoma. Postoperative pathological and immunohistochemical examinations are crucial, and surgical resection of the lesion and local radiotherapy are effective treatment methods.

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Plasmacytoma arising from a focus of chronic osteomyelitis. A case report.

Cited by 6 publications

References 0 publications

Solitary Plasmacytoma in the Setting of Langerhans Cell Histiocytosis

Solitary Plasmacytoma in the Setting of Langerhans Cell Histiocytosis

Squamous cell carcinoma arising in chronic osteomyelitis

Solitary bone plasmacytoma of the tibia presenting as chronic osteomyelitis: A rare case report and literature review

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