Plasmacytoid Urothelial Carcinoma of the Bladder: Histological and Clinical Features of 5 Cases

Fritsche, Hans Martin; Burger, Maximilian; Denzinger, Stefan; Goebell, Peter J.; Hartmann, Arndt

doi:10.1016/j.juro.2008.07.035

Cited by 75 publications

(83 citation statements)

References 7 publications

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“…All of these cases lacked E-cadherin expression. 43,46,49,51,57 In our study, all four cases of plasmacytoid urothelial carcinoma, and two cases of urothelial carcinoma with mixed plasmacytoid and signet ring cell differentiation and urothelial carcinoma with signet ring cell differentiation lacked E-cadherin expression (Fisher's exact test, P-value p0.0001). Angiolymphatic invasion was identified in half of these cases and the depth of invasion ranged from lamina propria invasion to extravesical extension.…”

Section: Discussionmentioning

confidence: 49%

“…Three large series and numerous case reports have been published. [21][22][23][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60] This variant of urothelial carcinoma is considered to be a poorly differentiated neoplasm with aggressive behavior and poor prognosis. Microscopically, these tumors are diffusely infiltrative and the individual cells are often discohesive.…”

Section: Discussionmentioning

confidence: 99%

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E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinoma

et al. 2011

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Loss of E-cadherin expression has been linked to the invasive phenotypes of a variety of neoplasms, including lobular breast cancer. The expression of E-cadherin in variants of urothelial carcinoma relative to usual-type urothelial carcinoma, maximum depth of invasion and angiolymphatic invasion has not been well characterized. A total of eight cases of micropapillary urothelial carcinoma, four cases of plasmacytoid urothelial carcinoma, two cases of urothelial carcinoma with signet ring cell differentiation and two cases of urothelial carcinoma with mixed plasmacytoid and signet ring cell differentiation, all obtained from cystectomy/cystoprostatectomy cases, were identified. In all nine cases of usual-type invasive and noninvasive high-grade urothelial carcinoma were also included in the study. Immunohistochemical staining of E-cadherin was performed in all cases. Pathological parameters including depth of invasion and presence of angiolymphatic invasion were documented. Maximum depth of invasion: In micropapillary urothelial carcinoma, extravesical extension was seen in three of eight cases; muscularis propria invasion in four of eight cases; and lamina propria invasion in one of eight cases. In plasmacytoid urothelial carcinoma, extravesical extension was observed in two of four cases, and muscularis propria invasion and lamina propria invasion in one of four cases each. In urothelial carcinoma with signet ring cell differentiation, extravesical extension and muscularis propria invasion was seen in one of two cases each. In urothelial carcinoma with mixed plasmacytoid and signet ring cell differentiation, muscularis propria invasion and lamina propria invasion was observed in one of two cases each. In usual-type high-grade urothelial carcinoma, extravesical extension was seen in six of nine cases and noninvasive in three of nine cases. In angiolymphatic invasion, micropapillary urothelial carcinoma was observed in eight of eight cases; plasmacytoid urothelial carcinoma in two of four cases; urothelial carcinoma with signet ring cell differentiation in one of two cases; and urothelial carcinoma with mixed plasmacytoid and signet ring cell differentiation in one of two cases. Usual-type high-grade urothelial carcinoma was seen in six of nine cases. E-cadherin expression: All eight cases of micropapillary urothelial carcinoma were positive for E-cadherin in the micropapillary component and adjacent usual-type urothelial carcinoma. The four cases of plasmacytoid urothelial carcinoma, two cases of urothelial carcinoma with signet ring cell differentiation and two cases of urothelial carcinoma with mixed plasmacytoid and signet ring cell differentiation were all negative for E-cadherin. All nine additional cases of usual-type high-grade urothelial carcinoma were diffusely positive for E-cadherin. E-cadherin is diffusely positive in usual-type urothelial carcinoma and micropapillary urothelial carcinoma, irrespective of pathological stage and angiolymphatic invasion. Loss of E-cadherin expression may be a marker of...

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinoma

et al. 2011

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“…36,37 Although there is insufficient evidence to make any concrete recommendations from these small case series, this variant has displayed aggressive behaviour in the cases described thus far.…”

Section: Plasmacytoidmentioning

confidence: 92%

Histologic variants of urothelial bladder cancer and nonurothelial histology in bladder cancer

Chalasani

Chin

Izawa

2013

CUAJ

158

113

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Bladder cancer can be classified histologically as urothelial or non-urothelial. Urothelial cancer has a propensity for divergent differentiation, which has increasingly been recognized in recent years due to heightened awareness and improved immunohistochemistry techniques. Furthermore, the recent World Health Organization classification of urothelial cancers improved clarity on this issue, with its listing of 13 histologic variants of urothelial cancer. The divergent differentiation patterns include, amongst others, squamous, glandular, micropapillary, nested, lymphepithelioma-like, plasmacytoid and sarcomatoid variants of urothelial cancer. Attempts to quantify the amount of divergent differentiation present, such as using the nonconventional differentiation number, have been made recently, which will improve the ability to compare publications from different centres. Genetic-based studies have indicated that the histologic variants of urothelial cancer arise from a common clonal precursor. Mostly, the current evidence suggests that urothelial cancer with divergent differentiation has a worse prognosis when compared with pure urothelial cancer. This article will review the current literature on variant histologies of urothelial cancer, and well as new developments in pure squamous cell carcinoma, small cell carcinoma and adenocarcinoma of the bladder.

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“…Since 2011, at least 71 cases have been reported in the literature [2]. Plasmacytoid urothelial carcinoma is rare, accounting for less than 3% of invasive urothelial carcinomas [3]. The main histologic findings include dyshesive, oval to round plasmacytoid cells arranged in cords, nests, single file or with sheet-like growth.…”

Section: Discussionmentioning

confidence: 99%

“…The main histologic findings include dyshesive, oval to round plasmacytoid cells arranged in cords, nests, single file or with sheet-like growth. The malignant cells contain abundant eosinophilic cytoplasm, eccentric, enlarged hyperchromatic nuclei, small nucleoli, and numerous mitoses [3,4,5,6,7]. …”

Section: Discussionmentioning

confidence: 99%

Metastatic Plasmacytoid Urothelial Carcinoma: A Case Report and Review of the Literature

Olsen¹,

Anderson²

2013

Acta Cytologica

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Plasmacytoid urothelial carcinoma is a rare form of invasive urothelial carcinoma first described in 1991 by Sahin et al. [Acta Cytol 1991;35:277-280]. Since this original publication, over 70 cases of plasmacytoid urothelial carcinoma have been described. A small number of cytologic descriptions have been published, including cases involving cerebrospinal fluid cytology, bladder washings and urine cytology. To our knowledge, we describe the first fine needle aspiration of metastatic plasmacytoid urothelial carcinoma in a 75-year-old man who presented with a pathologic fracture of the L4 vertebral body. One of the diagnostic pitfalls in the cytologic evaluation of this rare malignancy is the positive staining with CD138. While CD138 is a marker for plasma cell differentiation, it is also positive in plasmacytoid urothelial carcinoma. In addition to recognizing the cytomorphologic details, a full immunohistochemical panel is helpful in properly characterizing this entity. A brief discussion of long-term prognosis and treatment benefit is provided.

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Plasmacytoid Urothelial Carcinoma of the Bladder: Histological and Clinical Features of 5 Cases

Cited by 75 publications

References 7 publications

E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinoma

E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinoma

Histologic variants of urothelial bladder cancer and nonurothelial histology in bladder cancer

Metastatic Plasmacytoid Urothelial Carcinoma: A Case Report and Review of the Literature

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