E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinoma

Lim, Matthew; Adsay, Volkan; Grignon, David J.; Osunkoya, Adeboye O.

doi:10.1038/modpathol.2010.187

Cited by 47 publications

(27 citation statements)

References 55 publications

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“…In our study, we observed re-expression of E-cadherin that was more expressed in pT3 local tumors (69.3%) and that were able to disseminate or recur locally. Interestingly, in agreement with our data, a recent study published by Lim et al (22) found normal expression of E-cadherin in both usual and micropapillary urothelial bladder carcinomas, and that was independent of tumor stage, tumor grade or presence of microvascular invasion. In their study, they proposed that loss of E-cadherin expression may be a characteristic of a histologically special plasmocytoid or signed ring cell urothelial carcinoma.…”

Section: Discussionsupporting

confidence: 82%

Immune expression of E-cadherin and α, β and γ-Catenin adhesion molecules and prognosis for upper urinary tract urothelial carcinomas

et al. 2012

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ARTIcLE INFO _________________________________________________________ ___________________Introduction: Cell adhesion molecules (CAM) are required for maintaining a normal epithelial phenotype, and abnormalities in CAM expression have been related to cancer progression, including bladder urothelial carcinomas. There is only one study that correlates E-cadherin and α-, β-and γ-catenin expression with prognosis of upper tract urothelial carcinomas. Our aim is to study the pattern of immune expression of these CAMs in urothelial carcinomas from the renal pelvis and ureter in patients who have been treated surgically. Our goal is to correlate these expression levels and characteristics with well-known prognostic parameters for disease-free survival. Materials and Methods: We evaluated specimens from 20 patients with urothelial carcinomas of the renal pelvis and ureter who were treated with nephroureterectomy or ureterectomy between June 1997 and January 2007. CAM expression was evaluated by immunohistochemistry in a tissue microarray and correlated with histopathological characteristics and patient outcomes after a mean follow-up of 55 months. Results: We observed a relationship between E-cadherin expression and disease recurrence. Disease recurrence occurred in 87.5% of patients with strong E-cadherin expression. Only 50.0% of patients with moderate expression and 0% of patients with weak or no expression of E-cadherin had disease recurrence (p = 0.014). There was also a difference in disease-free survival. Patients with strong E-cadherin expression had a mean disease-free survival rate of 49.1 months, compared to 83.9 months for patients with moderate expression (p = 0.011). Additionally, an absence of α-catenin expression was associated with tumors that were larger than 3 cm (p = 0.003). Conclusions: We demonstrated for the first time that immune expression of E-cadherin is related to tumor recurrence and disease-free survival rates, and the absence of α-catenin expression is related to tumor size in upper tract urothelial carcinomas.

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Section: Discussionsupporting

confidence: 82%

Immune expression of E-cadherin and α, β and γ-Catenin adhesion molecules and prognosis for upper urinary tract urothelial carcinomas

et al. 2012

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“…Only in case of T4 tumors, the expression of all markers showed stable high values. These observations are in agreement with the results of Lim et al (2011). Divergence in the case of E-cadherin expression in T4 tumors can be explained by the fact that in our group we had only one patient in this stage.…”

Section: Disscussionsupporting

confidence: 82%

Immunohistochemical Analysis of Urothelial Bladder Cancers

Bevizova¹

2013

OnLine Journal of Biological Sciences

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Malignant cancers of urinary bladder are the second most common malignancy of the urinary tract and the fourth most common malignancy in general, especially in men. The aim of this study was a retrospective analysis of selected markers (p53, Ki-67 and E-cadherin) of urinary bladder cancers from the Department of Urology in Bratislava, Slovak Republic between years 2007 and 2009. We analysed 244 patients (202 males, 42 females) with diagnosed bladder cancer via cystoscopy and subsequent transurethral resection. Patients' age varied from 36 to 98 years. Obtained samples were fixed by 10% buffered formalin for 24 to 48 h. Subsequently, they were dehydrated in ascending ethanol series and embedded in paraffin. The parafin sections of 5 µ m were prepared by microtome and they were stained by haematoxylin and eosin. The antibodies against to p53, Ki-67 and E-cadherin were used in immunohistochemical analysis. Statistical evaluation was performed via SPSS using non-parametric Kruskal-Wallis test and p values<0.05 were considered statistically significant. No significant differences in the expression of selected markers were found between genders. Expression of p53 and Ki-67, in G1 and G2 of low grade tumours was lower in comparison to their expression in G3 tumors. Expression of E-cadherin was the opposite in this case. The expression of p53 and Ki-67 positively correlated with tumor's depth of invasion, while the expression of E-cadherin significantly decreased. In case of T4 tumors, the expression of all markers exhibited consistently high values. When analysing tumor multiplicity, the expression of p53 and Ki-67 significantly decreased, while the expression of E-cadherin significantly increased. Based on the obtained results it can be concluded that the analysis of p53, Ki-67 and E-cadherin expression is essential for diagnostics and prognostics of bladder cancer and should be routinely used in daily practise together with "conventional" markers to improve prognosis estimation.

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“…Positivity for epithelial markers, including cytokeratins and epithelial membrane antigen, confirms the epithelial nature of plasmacytoid UC [6, 7, 9]. It has recently been reported that the majority of plasmacytoid UCs show negative or markedly reduced membranous staining for E-cadherin, which mediates cell-to-cell adhesion, suggesting that the loss of E-cadherin expression may be a prominent feature of plasmacytoid UC [9, 10]. In the present case, only the plasmacytoid UC component was negative for membranous E-cadherin, whereas the other histological components were positive for membranous E-cadherin, which is consistent with previous reports [9, 10].…”

Section: Discussionmentioning

confidence: 97%

“…Several previous studies have examined the immunohistochemical features of plasmacytoid UC [6, 7, 9, 10]. CD138 is typically positive in plasmacytoid UC, as is the case in many other carcinomas as well as plasma cell neoplasia [7, 9].…”

Section: Discussionmentioning

confidence: 99%

A Case of Urinary Bladder Urothelial Carcinoma with Squamous, Glandular, and Plasmacytoid Differentiation

et al. 2014

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We report an extremely rare case of urothelial carcinoma (UC) of the urinary bladder with diverse histological differentiation into squamous, glandular, and plasmacytoid components. A 65-year-old man presented with gross hematuria. Cystoscopy showed a papillary-growing tumor with a wide-based stalk on the left wall of the urinary bladder. Based on the clinical diagnosis of locally invasive bladder cancer, the patient underwent radical cystectomy. Histological examination of the cystectomy specimen revealed UC with histological differentiation into multiple tumor subtypes. The tumor was composed of squamous cell carcinoma with marked keratinization, adenocarcinoma characterized by tall columnar cells with scattered goblet cells, conventional high-grade invasive UC and UC in situ, and plasmacytoid UC composed of discohesive cancer cells with eccentric nuclei and eosinophilic cytoplasm that diffusely infiltrated the bladder wall through the serosal surface. Immunohistochemically, the loss of membranous E-cadherin expression was noted only in the plasmacytoid UC component. The patient developed local recurrences 2 months postoperatively and died of the disease 6 months postoperatively. It is critical to correctly diagnose the histological variants of UC to predict a patient's prognosis and to determine the optimal treatment.

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E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinoma

Cited by 47 publications

References 55 publications

Immune expression of E-cadherin and α, β and γ-Catenin adhesion molecules and prognosis for upper urinary tract urothelial carcinomas

Immune expression of E-cadherin and α, β and γ-Catenin adhesion molecules and prognosis for upper urinary tract urothelial carcinomas

Immunohistochemical Analysis of Urothelial Bladder Cancers

A Case of Urinary Bladder Urothelial Carcinoma with Squamous, Glandular, and Plasmacytoid Differentiation

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