Plasmablastic Lymphoma in an Immunocompetent Patient with MDS/MPN with Ring Sideroblasts and Thrombocytosis—A Case Report

Abstract

Plasmablastic lymphoma (PBL) is a rare, aggressive type of B-cell non-Hodgkin lymphoma with the vast majority of patients responding poorly to treatment or progressing shortly thereafter. Cyclophosphamide-doxorubicin-vincristine-prednisolone (CHOP) or CHOP-like regimens have disappointing results in this setting. We report a case of PBL arising in a previously diagnosed myelodysplastic/myeloproliferative (MDS/MPN) with ring sideroblasts and thrombocytopenia (RS-T), HIV-negative patient treated with the combination of CHOP and bortezomib. The patient achieved complete metabolic response, which has lasted one year, longer by far than would have been expected with the sole use of CHOP.

Coexistence of Myeloid and Lymphoid Neoplasms: A Single-Center Experience

“…A trial of lenalidomide was performed, which resulted in transfusion dependency, so treatment was stopped prematurely after a few days. On the other hand, the underlying MDS/MPN-RS-T did not seem to adversely affect treatment outcome of Patient 6, a fitter patient, who received 6 cycles of bortezomib/CHOP, resulting in an astonishing relapse-free survival, as previously reported [16].…”