Plasma xanthine oxidase, superoxide dismutase and glutathione peroxidase activities and uric acid levels in severe and mild pre‐eclampsia

Abstract

The aim of the present study was to measure plasma uric acid (UA) levels and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and xanthine oxidase (XO) activities and to evaluate the relationship between these parameters and the severity of pre-eclampsia. Twenty-five pre-eclamptic, 15 healthy pregnant and 15 non-pregnant women were enrolled in this study. Increased mean plasma XO activity was found to be higher in both pre-eclampsia groups than in the healthy pregnant group. Plasma UA levels were the highest in the severe pre-eclampsia group among the study groups. SOD and GSH-Px activities were significantly lower in both pre-eclampsia groups than in the healthy pregnant group (p < 0.005 and p < 0.001, respectively). Increased XO and decreased SOD and GSH-Px activities may contribute to the pathophysiological mechanisms of pre-eclampsia and increased UA may serve a protective role responding to superoxide radicals arising from increased XO activity or other sources in pre-eclampsia.

Total Antioxidant Capacity and Antioxidant Enzymes in Serum, Saliva, and Gingival Crevicular Fluid of Preeclamptic Women With and Without Periodontal Disease

“…Although some studies 45,46 documented an imbalance between increased oxidant status and a decreased antioxidant system in women with preeclampsia, contradictory results were reported in other studies. Increased, 47,48 decreased, 49 or unaltered 50,51 glutathione peroxidase activity and decreased 50 or unaltered 48 superoxide dismutase activity in the serum of pregnant women with preeclampsia have been reported.…”

Total oxidant, antioxidant, and paraoxonase levels in babies born to pre‐eclamptic mothers

“…Meanwhile, a few studies in the literature have examined the severity of pre‐eclampsia and the degree of oxidative stress in the baby . Chamy et al .…”

Serum uric acid as a novel marker for uterine atony and post-spinal vasopressor use during cesarean delivery

“…3 Indeed, oxidative stress is considered an essential contributor to the development and maintenance of preeclampsia, 4 and serum UA has subsequently been proposed as an appropriate marker for the severity of this stress. 5,6 Oxidative stress is witnessed in patients with heart failure, 7 for whom an elevated serum UA correlates with depressed myocardial contractility, impaired hemodynamic responses, and increased vascular tone, 8 and serves as an independent predictor of a poor prognosis. 9 In such cases, XO is the major source of elevated UA and ROS.…”