Plasma Volume in Sickle Cell Disease

Barreras, Luis; Lw, Diggs; Lipscomb, Alys

doi:10.1097/00007611-196604000-00019

Cited by 14 publications

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“…Measurements of systemic hemodynamics are relevant to and offer insights regarding this recognized reduction in mean arterial pressure in patients with SCD. In these patients, total blood volume (106), plasma volume (14), and cardiac output and index (20,28,68) are all increased; systemic vascular resistances are significantly reduced, attaining no more than 50–60% of control values (28,104). The augmentation in cardiac output and the reduction in systemic vascular resistances are both heightened during sickle crisis as compared to these indices determined in patients during steady state (104).…”

Section: Overview Of Systemic and Regional Hemodynamics In Scdmentioning

confidence: 99%

The Perfusion Paradox and Vascular Instability in Sickle Cell Disease

2004

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Sickle cell disease (SCD) exhibits a curious coexistence of contrasting perfusion profiles in the circulatory system: hypoperfusion is endemic in microcirculatory beds occluded by hemoglobin S-containing erythrocytes while hyperperfusion characterizes the systemic (macro)circulation and a number of regional vascular circuits. This review highlights this perfusion paradox of SCD, focusing on forearm blood flow and the renal circulation, and exploring the extent to which alterations in vasoactive systems (such as nitric oxide and prostanoids) are involved. Also reviewed are the mechanisms and pathways that contribute to altered vascular reactivity and vascular instability observed in SCD. Finally, the possibility that the induction of heme oxygenase-1, recently described in SCD, may confer a protective response in the vasculature and other tissues is discussed.

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