Renal Manifestations of Sickle Cell Disease

National Study on Natural History of Renal Allografts in Sickle Cell Disease or Trait

“…The crisis is commonly painful and less commonly aplastic in type but may also be hemolytic or sequestration in type [8], Renal abnormalities in pa tients with sickle cell disease include infarction of renal parenchyma [1,2], intermittent hematuria with medullary necrosis [3,4], morphologic alteration of the so-called 'sickle nephropathy' [4], thromboticcrises [2], and nephrotic syndrome [4,5], In sickle cell trait, hematuria [9] has been reported. In view of the fact that at least an estimated 240 people with renal allografts are continually living in the face of these supposed complications, we searched the literature for any such report, but there were only two.…”

Sickle cell disease: chest and abdominal manifestation-A CT based study

“…It may be associated with complications and finally renal failure. Also, there is a possible bacterial infection of the scarred renal tissues and functional tubule abnormalities in conjunction with the compromised immunity, leading to abscess formation [26,27] Table(3) presented the lungs CT manifestation in SCA : pleural effusion, pneumonia ,atelectasis, ground glass nodules ,consolidation ,fibrosis lung abscess which was found in different ages as well; at all types of SCD including Hb SS ,Hb SC ,Hb SB 0-thalassemia ,Hb SB+ thalassemia that are presented in table ( 8) Similar studies have mentioned that the acute chest syndrome is one of the most common causes of hospitalization and even death of SCA patients, pulmonary vascular obstruction. [28]and pleural effusion may also be seen, [29,30] Patients with SCA may develop obstructive or restrictive lung diseases, when there is a progressive decline in the pulmonary functions .This may be explained by established fibrotic lung changes from repeated episodes of pulmonary infective and vaso-occlusive events.…”

Sickle Cell Disease in the Sudan: Clinical and Biochemical Aspects

“…The kidney suffers multiple functional abnormalities and the well recognized one is the impaired ability to concentrate the urine, known as hyposthenuria (5,144). Even the heterozygous sickle cell individuals are known to suffer from this abnormality (14).…”

“…Even the heterozygous sickle cell individuals are known to suffer from this abnormality (14). Other abnormalities in the kidney include glomerular sclerosis, vascular congestion, edema, focal scarring and occasional papillary necrosis (144). It has been reported that 25% of patients with sickle cell disease have abnormal protein excretion in urine (32,65).…”