Plasma vitamin D and parathormone are associated with obesity and atherogenic dyslipidemia: a cross-sectional study

Abstract

BackgroundLow concentrations of plasma vitamin D (25(OH)D) have been associated with the development of metabolic syndrome (MetS), obesity, diabetes and cardiovascular disease. The objective of this study was to quantify the associations between 25(OH)D and parathormone (PTH) plasma levels and obesity, the presence of MetS, diabetes or atherogenic dyslipidemia (AD) in a large sample of individuals with different degrees of adiposity.MethodsRetrospective study of all patients who had attended the obesity clinics in a Spanish hospital between 2009 and 2011, and whose concentrations of PTH, 25(OH)D, calcium and alkaline phosphatase had been determined (n=316, 75.9% women). Individuals were categorized by degree of adiposity, presence of MetS, and other comorbidities.ResultsPTH increased but 25(OH)D and calcium decreased with increasing adiposity. The prevalence of 25(OH)D deficiency or insufficiency increased with obesity (<10% when BMI<45kg/m2, and 26% when >50). The prevalence of hyperparathyroidism increased from 12% in non-obese to 47.5% in morbidly obese individuals with BMI>50 kg/m2. Low plasma 25(OH)D and high PTH concentrations were associated with an increased risk of MetS and AD. These associations disappeared, except in the case of AD for 25(OH)D when adjusting for BMI. Regression analysis revealed that BMI and age or seasonality were independent predictors of PTH and 25(OH)D levels, respectively.ConclusionsBMI was the variable most strongly associated with plasma 25(OH)D and PTH concentrations in our study. Low 25(OH)D and high PTH concentrations were not independently associated with an increased risk of MetS, or diabetes. Our data support a possible contribution of plasma 25(OH)D to the pathogenesis of hypertriglyceridemia and AD through inflammation.

e relationship between vitamin D de ciency and erythrocyte sedimentation rate in patients with diabetes

“…Hyperglycemia and dyslipidemia may affect each other causally (27). Furthermore, similar to our study, low 25(OH)D levels were associated with obesity and dyslipidemia in previous studies (27,28). There are data demonstrating that vitamin D deficiency may influence dyslipidemia through various mechanisms such as insulin secretion, lipotoxicity, gastrointestinal calcium absorption, inflammation, and increase in the parathyroid hormone level (27).…”

Interplay of vitamin D and metabolic syndrome: A review

“…The results revealed higher prevalence of vitamin D deficiency with increased adiposity further an increase in hyperparathyroidism was observed from 12 percent in non-obese to 47.5 percent in morbidly obese individuals with BMI > 50 kg/m 2 . Higher risk of metabolic syndrome and atherogenic dyslipidemia was found strongly associated with low serum 25(OH) D and high PTH concentrations [47]. On the contrary, Kienreich et al [7], reported no significant effect of vitamin D status on obesity.…”

Relationship Between Parathormone and Obesity-Linked Disorders

“…In these studies, there was no correlation between PTH and MetS after adjustment for confounders. 24,25 In hyperparathyroidism, there were alterations in glucose metabolism as demonstrated in several studies. [26][27][28][29][30][31] The prevalence of diabetes mellitus in primary hyperparathyroidism was three-fold higher than the expected prevalence in the general population.…”