e relationship between vitamin D de ciency and erythrocyte sedimentation rate in patients with diabetes

Kaya, Tezcan; Akçay, Emine Ülkü; Ertürk, Zeynep; Ergenç, Hasan; Tamer, Ali

doi:10.3906/sag-1712-28

Cited by 4 publications

(4 citation statements)

References 30 publications

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“…The association between vitamin D deficiency and increased risk of inflammation and respiratory infections was stated in many studies; a study by Lehouck et al 28 showed the role of high vitamin D supplements in reducing COPD exacerbations. In addition to a study conducted by Kaya et al 29 who reported the strong association between vitamin D with ESR as a marker of inflammation in diabetic patients. Furthermore, Panfili et al, 30 stated that vitamin D deficiency contributes to acute respiratory distress syndrome (ARDS), and indicated that vitamin D has a role in preventing lung fibrosis which is a common complication and a long-term concern in these patients.…”

Section: Discussionmentioning

confidence: 84%

Vitamin D deficiency as a predictor of severity in patients with COVID-19 infection

et al. 2021

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Background: As an immune modulator, vitamin D has been implicated in the coronavirus disease 2019 (COVID-19) severity. This study aimed to investigate the association between vitamin D levels and the severity of COVID-19 infection. Methods: A cross-sectional study, which included 124 patients diagnosed with COVID-19 and were selected from Ain Shams University Hospitals and assigned to two groups; mild and severe COVID-19. All patients underwent detailed history taking, clinical data, and different laboratory investigations as complete blood count, blood urea nitrogen, serum creatinine, liver enzymes, C-reactive protein, D-dimer, ferritin and serum vitamin D concentration. In addition to findings of initial chest computed tomography (CT) were recorded. COVID-19 Reporting and Data System (CO-RADS) and CT chest severity scores (CT SS) were reported. Results: In this study of 124 COVID-19-positive individuals, a high prevalence of hypovitaminosis D was found (97.6%). Lower vitamin D levels were significantly associated with more severe COVID-19 cases ( p-value < 0.001), higher blood levels of inflammatory markers including (D-dimer, CRP, and ferritin), a higher CT SS and longer disease duration. Serum vitamin D can be used as a predictor for the severity of COVID-19 infection with a specificity of 96.6%, and sensitivity of 45.5%. Conclusion: The high frequency of hypovitaminosis D in severe COVID-19 patients provides further evidence of a potential link to poor prognosis and severity of the disease, so vitamin D deficiency may be a marker of poor prognosis in these patients.

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Section: Discussionmentioning

confidence: 84%

Vitamin D deficiency as a predictor of severity in patients with COVID-19 infection

et al. 2021

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“…16 Studies have confirmed that vitamin D can have impacts on all of these pathophysiological pathways through vitamin D receptors on pancreatic β cells, skeletal muscle and adipocytes. 17 First, 1.25(OH) 2 D binds to VDRs on pancreatic β cells and directly affects insulin secretion. 18,19 In addition, 1.25(OH) 2 D can increase insulin receptor expression, activate insulin receptors and enhance insulin mediated glucose transport.…”

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confidence: 99%

The Relationship Between Hemoglobin Glycation Variation Index and Vitamin D in Type 2 Diabetes Mellitus

Li¹,

Wang²,

Jia³

et al. 2021

DMSO

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Objective This study aimed to investigate the relationship between hemoglobin glycation variation index (HGI) and vitamin D in patients with type 2 diabetes mellitus (T2DM). Materials and Methods This is a cross-sectional study that recruited 347 patients with T2DM. The subjects were divided into no vitamin D deficiency group (25(OH)D ≥20 ng/mL) and vitamin D deficiency group (25(OH)D < 20 ng/mL). HGI was calculated as the difference between the measured and predicted values of HbA1c using the linear relationship between HbA1c level and fasting plasma glucose levels. All study participants were divided into high HGI and low HGI groups using the median of HGI as the boundary. At last, the subjects were divided into male group and female group, and these groups were further subdivided into vitamin D deficiency group and no vitamin D deficiency group. Results The levels of HGI were significantly higher in the vitamin D deficiency group compared with the no vitamin D deficiency group for all patients. The same was true for female patients but not for male patients. The prevalence of vitamin D deficiency in the high HGI group was higher than that in the low HGI group. The high HGI group had lower vitamin D levels compared to the low HGI group. Compared to the male group, the female group had lower vitamin D levels but higher HGI levels. A negative correlation existed between 25(OH) D and HGI in all subjects, as well as in the female-only subgroups. In the male-only subgroups, there was no correlation between them, and this positive correlation still existed after adjusting for other factors in multilinear regression analysis. Conclusion Our study showed for the first time that HGI is inversely associated with vitamin D in all patients with T2DM, and the correlation was also found in female patients, but not in male patients.

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“…18 In another study conducted in our country on 294 diabetic patients, vitamin D deficiency was found in 47.9% of patients and vitamin D insufficiency was found in 32.9% of patients. 19 Only 20.3% of the patients had sufficient 25(OH)D levels in our study, which indicates that 25(OH)D deficiency is still prevalent in our society and should be closely monitored and treated. Gender differences in the prevalence of 25(OH)D are controversial.…”

Section: Discussionmentioning

confidence: 58%

The Relationship Between Orthostatic Hypotension and Vitamin D Deficiency in Patients with Uncontrolled Type 2 Diabetes Mellitus

YİĞİT

Sivritepe

Karabulut

et al. 2022

Online Türk Sağlık Bilimleri Dergisi

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Objective: Vitamin D deficiency is common in diabetic patients, and studies showed that it could lead to neuropathy. Therefore, we aimed to determine relationship between 25-hydroxyvitamin D (25(OH)D) levels and orthostatic hypotension (OH) which is a component of autonomic neuropathy in diabetic patients.Materials and Methods: A total of 118 patients with Type 2 diabetes mellitus and aged 50-65 years were included. Patients were divided into two groups as OH present and OH not present. 25(OH)D and other variable parameters were evaluated between these two groups.Results: A total of 118 patients, 66 female and 52 male, were included in this cross-sectional study. The mean age of the patients was 56.2±3.2 years. 25(OH)D levels were found to be significantly lower in the group with OH (p<0.026). Age and sex-adjusted regression analysis were performed to examine the relationship between 25(OH)D level and OH. It was found that 25(OH)D didn’t predict the presence of OH in the univariate and multivariate analyses (p >0.05).Conclusion: 25(OH)D levels are significantly lower in diabetic patients with OH. Although an independent relationship between them has not been demonstrated, it can be thought that correcting Vitamin D deficiency will be beneficial in the treatment of OH.

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e relationship between vitamin D de ciency and erythrocyte sedimentation rate in patients with diabetes

Cited by 4 publications

References 30 publications

Vitamin D deficiency as a predictor of severity in patients with COVID-19 infection

Vitamin D deficiency as a predictor of severity in patients with COVID-19 infection

The Relationship Between Hemoglobin Glycation Variation Index and Vitamin D in Type 2 Diabetes Mellitus

The Relationship Between Orthostatic Hypotension and Vitamin D Deficiency in Patients with Uncontrolled Type 2 Diabetes Mellitus

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