Plasma vitamin C assay in women of reproductive age in Kampala, Uganda, using a colorimetric method

Kowal, Paul; Tumwesigye, Nazarius Mbona; Wandabwa, Julius; Wamuyu-Maina, Gakenia; Bimenya, G. S.; Okong, Pius

doi:10.1111/j.1365-3156.2011.02907.x

Cited by 14 publications

(11 citation statements)

References 29 publications

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“…The vitamin C status of pregnant women is often lower than non-pregnant women, presumably due to hemodilution and active transfer of vitamin C to the fetus (Juhl et al, 2017a). Women with complications of pregnancy can have lower vitamin C status still (Kiondo et al 2012). A significant correlation was recently reported between poor vitamin C status and increased risk of complications in pregnant women with type 1 diabetes (Juhl et al, 2017b).…”

Section: Factors Requiring Increased Intake: Pregnancy and Lactationmentioning

confidence: 99%

Discrepancies in global vitamin C recommendations: a review of RDA criteria and underlying health perspectives

Carr

Lykkesfeldt

2020

Critical Reviews in Food Science and Nutrition

115

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The concept of a 'recommended dietary allowance' (RDA) and similar terms describing the daily intake of essential nutrients recommended for healthy individuals is widely used by various health authorities around the world. For vitamin C, however, there remain significant discrepancies in the criteria used to establish dietary recommendations and consequently, global recommendations for daily vitamin C intake vary by more than five fold. While it appears that the scientific data underlying the recommendations are more or less the same, the interpretation differs considerably. Moreover, although a number of the assumptions used in e.g. the body pool estimates of the 1960s and 1970s have later been proven wrong and give rise to significant underestimations, these data are still used as the main support of several recommendations. Aspects that modify vitamin C requirements, such as gender, age, pregnancy, lactation, and smoking, have been taken into consideration by many but not all regulatory authorities, and are thus subject of debate. In contrast, body weight, a significant predictor of vitamin C status and requirement, has not been taken into consideration with respect to vitamin C recommendations, even in the face of the looming global obesity pandemic. The present review examines the discrepancies in vitamin C dietary recommendations of international authorities and critically discusses representative examples of criteria and the underlying health perspectives used to derive current recommended intakes of vitamin C. New biological signatures of vitamin C nutriture are also explored with regard to their potential use for future updates of dietary recommendations.

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Section: Factors Requiring Increased Intake: Pregnancy and Lactationmentioning

confidence: 99%

Discrepancies in global vitamin C recommendations: a review of RDA criteria and underlying health perspectives

Carr

Lykkesfeldt

2020

Critical Reviews in Food Science and Nutrition

115

View full text Add to dashboard Cite

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“…Pregnant women typically have lower vitamin C status compared with nonpregnant women [34]. This is most likely due to hemodilution, as well as active transfer of the vitamin to the developing fetus [95].…”

Section: Pregnancy and Lactationmentioning

confidence: 99%

Factors Affecting Vitamin C Status and Prevalence of Deficiency: A Global Health Perspective

2020

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A recent review of global vitamin C status has indicated a high prevalence of deficiency, particularly in low- and middle-income countries, as well as in specific subgroups within high-income countries. Here, we provide a narrative review of potential factors influencing vitamin C status globally. The in vivo status of vitamin C is primarily affected by dietary intake and supplement use, with those who supplement having a higher mean status and a lower prevalence of deficiency. Dietary intake can be influenced by cultural aspects such as traditional cooking practices and staple foods, with many staple foods, such as grains, contributing negligible vitamin C to the diet. Environmental factors can also affect vitamin C intake and status; these include geographic region, season, and climate, as well as pollution, the latter partly due to enhanced oxidative stress. Demographic factors such as sex, age, and race are known to affect vitamin C status, as do socioeconomic factors such as deprivation, education and social class, and institutionalization. Various health aspects can affect vitamin C status; these include body weight, pregnancy and lactation, genetic variants, smoking, and disease states, including severe infections as well as various noncommunicable diseases such as cardiovascular disease and cancer. Some of these factors have changed over time; therefore, we also explore if vitamin C status has shown temporal changes. Overall, there are numerous factors that can affect vitamin C status to different extents in various regions of the world. Many of these factors are not taken into consideration during the setting of global dietary intake recommendations for vitamin C.

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“…29 Regarding the relation between maternal age and vitamin C levels, similar to our results Kiondo et al found no association between maternal age and vitamin C levels. 30 Conclusion Maternal vitamin C level has a significant positive impact on neonatal anthropometry and placental weight while negatively correlating with placental apoptosis. This denotes an important role of vitamin C during pregnancy.…”

Section: Discussionmentioning

confidence: 98%

Maternal–cord blood vitamin C status and its relation to fetal growth and placental apoptosis

Hegazy¹,

Younis²,

Nada³

et al. 2014

Egyptian Pediatric Association Gazette

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Background: Although the antioxidant property of vitamin C as well as its endothelial function promotion are well documented, its role in fetal growth during pregnancy is still not conclusive in previous studies. Objectives: This study aimed to estimate maternal and cord blood vitamin C level and to detect its influence on neonatal growth as well as placental weight and placental apoptosis. Methods: The study was conducted on 60 healthy singleton pregnant women and their full term neonates at Ain Shams University Hospital in Egypt. Maternal and cord blood vitamin C plasma level estimation as well as quantitative analysis of placental apoptotic index were done in addition to full anthropometric assessment for delivered neonates. Results: There was a positive significant correlation between maternal and neonatal vitamin C levels (r = 0.838, P < 0.001). Positive significant correlations between maternal vitamin C levels and neonatal weight (r = 0.448 , P < 0.001), length (r = 0.67, P < 0.001), BMI (r = 0.52, P = 0.003), OFC (r = 0.60, P < 0.001) and placental weight (r = 0.373, P < 0.001) while a significant negative correlation with placental apoptotic index (r = À0.817, P < 0.001) were detected. Multiple regression analysis showed that placental weight was the most sensitive predictor of neonatal weight (t = 4.132, P < 0.001) followed by maternal vitamin C (t = 3.034, P = 0.006). Conclusion: Maternal vitamin C level has a significant positive impact on neonatal anthropometry and placental weight while negatively correlating with placental apoptosis. This denotes an important role of vitamin C in fetal and placental growth during pregnancy.

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Plasma vitamin C assay in women of reproductive age in Kampala, Uganda, using a colorimetric method

Cited by 14 publications

References 29 publications

Discrepancies in global vitamin C recommendations: a review of RDA criteria and underlying health perspectives

Discrepancies in global vitamin C recommendations: a review of RDA criteria and underlying health perspectives

Factors Affecting Vitamin C Status and Prevalence of Deficiency: A Global Health Perspective

Maternal–cord blood vitamin C status and its relation to fetal growth and placental apoptosis

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