Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring Study

Tucker, Katherine L.; Rich, Sharron; Rosenberg, Irwin H.; Jacques, Paul F.; Dallal, Gerard E.; Wilson, Peter W.F.; Selhub, Jacob

doi:10.1093/ajcn/71.2.514

Cited by 187 publications

(197 citation statements)

References 22 publications

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“…Thus, HO-B12 is a ubiquitous and sometimes predominant form of B12 in food [1]. The daily supply of B12 in a Western omnivorous diet is around 6 µg [3,4], well above the recommended daily allowance (RDA) of 2.4 µg [5].…”

Section: Introductionmentioning

confidence: 99%

Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population

et al. 2017

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Purpose We compare the effect of 8-week oral supplementation with cyano-B12 (currently used in vitamin pills) and hydroxo-B12 (predominant form in the diet) in a population with nutritional vitamin B12 deficiency. Methods Fifty-one healthy Indian adults with baseline serum cobalamin < 200 pmol/L were supplied for 8 weeks with daily oral supplements of 3-µg cyano-B12 (n = 15), 3-µg hydroxo-B12 (n = 16), or a placebo (n = 20). Blood at baseline, and each following week, was examined for total cobalamin, holotranscobalamin, methylmalonic acid, and homocysteine. Results The study groups did not differ at baseline and were characterized by [median (range)] serum cobalamin [128 (68-191)

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Section: Introductionmentioning

confidence: 99%

Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population

et al. 2017

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“…Among adults not using vitamin supplements, the relationship between plasma concentration of the vitamin and its intake from dairy products is similar to the relationship observed with the intake from cereals fortified with vitamin B 12 . However, the relationship with intake from meat, poultry or fish is weaker (5) . A Norwegian study showed that plasma vitamin B 12 increases with the amounts of vitamin B 12 provided by dairy products or fish but not with those provided by eggs or meat (6) .…”

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confidence: 99%

Bioavailability of vitamin B₁₂ in cows' milk

2011

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The natural source of vitamin B 12 in human diets comes from animal products. For example, one glass (250 ml) of milk provides approximately 50 % of the RDA (2·4 mg/d). It was hypothesised that the provision of vitamin B 12 from milk is more efficiently absorbed than the synthetic form used in vitamin supplements. Pigs (n 10) were used as a model for intestinal absorption of vitamin B 12 in humans to compare the net fluxes of vitamin B 12 across the portal-drained viscera (PDV; an indicator of intestinal absorption) after ingestion of meals complemented with conventional and vitamin B 12 -enriched (via injections to cows) milk (raw, pasteurised or microfiltrated) or with equivalent amounts of cyanocobalamin, the synthetic form used in supplements or unsupplemented. Net flux of vitamin B 12 across PDV after the ingestion of milk was positive, though not influenced by milk enrichment (P. 0·3) or technological processes (P¼0·8) and was greater than after ingestion of equivalent amounts of cyanocobalamin (cyanocobalamin v. all milk, P# 0·003). In fact, net fluxes of this vitamin were not different from 0 after either cyanocobalamin or the meal devoid of vitamin B 12 (unsupplemented v. cyanocobalamin, P¼ 0·7). The cumulative PDV fluxes during the 24 h following ingestion of meals complemented with milk varied from 5·5 to 6·8 mg. These values correspond to an efficiency of intestinal absorption of vitamin B 12 from milk varying between 8 and 10 %. Therefore, vitamin B 12 , which is abundant in cows' milk, is also substantially more available than the most commonly used synthetic form of this vitamin.

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“…This maximum folic acid limit was established because folic acid is known to mask anemia associated with vitamin B 12 deficiency, which are associated with the dose and duration of treatment with folic acid 70 . The non-occurrence of megaloblastic anemia may confuse the diagnosis and irreversible neurological damages may occur due to B 12 deficiency 10,43,70,72,90,91 . Ray et al 92 and Quinlivan et al 93 consider the possibility of adding vitamin B 12 besides folic acid, in cereal fortification programs.…”

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Fortification of industrialized foods with vitamins

Liberato

Pinheiro-Sant’Ana

2006

Rev. Nutr.

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A B S T R A C TVitamins are essential to life. Inadequate eating habits, high caloric intake and metabolic defects lead to micronutrient deficiencies, affecting more than two billion people worldwide. The increasing intake of industrialized foods, combined with low vitamin stability has led to the common practice of adding these nutrients to processed foods. This review discusses the terminology, availability, intake and risk of hypervitaminosis, due to the intake and nutritional importance of foods fortified with vitamins. The addition of nutrients should occur in foods that are effectively consumed by the target population and must meet the real needs of a significant segment of the population. In Brazil, a total of 166 products available in supermarkets are vitamin-enriched. A 10-year study involving children and adolescents in Germany showed that 90% of those surveyed used at least one fortified food. During this 10-year period, 472 fortified products were consumed. The enrichment of foods should be based on the needs of each country and, if possible, regional needs. For instance, in order to increase its intake, Vitamin D is added to foods in Denmark during the winter, mainly for the elderly. However, in Brazil, there is no evidence of the need to fortify food with this vitamin. A survey showed that of the 76 enriched dairy products, 37 contained vitamin D. Food-fortification is a very important strategy to solve nutritional deficiency problems, but it can also cause many health problems.Indexing terms: food, fortified; food habits. R E S U M O

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Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring Study

Abstract: In contrast with previous reports, plasma vitamin B-12 concentrations were associated with vitamin B-12 intake. Use of supplements, fortified cereal, and milk appears to protect against lower concentrations. Further research is needed to investigate possible differences in bioavailability.

Cited by 187 publications

References 22 publications

Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population

Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population

Bioavailability of vitamin B₁₂ in cows' milk

Fortification of industrialized foods with vitamins

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Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring Study

Cited by 187 publications

References 22 publications

Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population

Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population

Bioavailability of vitamin B12 in cows' milk

Fortification of industrialized foods with vitamins

Contact Info

Product

Resources

About

Bioavailability of vitamin B₁₂ in cows' milk