Plasma visfatin levels are positively associated with circulating interleukin-6 in apparently healthy Korean women

Seo, Ji A; Jang, Eun Suk; Kim, Baek Gil; Ryu, Ohk Hyun; Kim, Hee Young; Lee, Kye Won; Kim, Sin Gon; Choi, Kyung Mook; Baik, Sei Hyun; Choi, Dong Seop; Kim, Nan Hee

doi:10.1016/j.diabres.2007.04.016

Cited by 33 publications

(27 citation statements)

References 17 publications

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“…However, more recent in vivo and in vitro studies have suggested that visfatin may be related to insulin-resistance, endothelial dysfunction, and increased inflammation. [3][4][5][6] Despite these findings, it should be noted that comprehensive results do not yet exist about the pathophysiological role of visfatin. [4] Dialysis patients are suggested to have increased several adipocytokines (adiponectin, leptin, interleukin 6 [IL-6], tumor necrosis factor-α [TNF-α]), particularly due to low renal clearance.…”

Section: Introductionmentioning

confidence: 81%

“…[1,4,5] Additionally, a few studies have suggested that visfatin may have proinflammatory characteristics. [3,4,6] There are two studies in the literature demonstrating a positive relationship between serum level of IL-6 and visfatin. [3,6] Likewise, our study has also found an independent and significant positive relationship between visfatin and two of the important inflammatory cytokines, TNF-α and IL-6.…”

Section: Discussionmentioning

confidence: 99%

“…[3,4,6] There are two studies in the literature demonstrating a positive relationship between serum level of IL-6 and visfatin. [3,6] Likewise, our study has also found an independent and significant positive relationship between visfatin and two of the important inflammatory cytokines, TNF-α and IL-6. These results might confirm that visfatin might be a proinflammatory adipocytokine.…”

Section: Discussionmentioning

confidence: 99%

“…[8] Recently, a relationship between visfatin and these adipocytokines have been suggested in healthy subjects. [3,6] Increased levels of IL-6 and TNF-α have been demonstrated to be related with left ventricular hypertrophy (LVH) in dialysis patients. [8][9][10] This suggests a relationship between visfatin, which is thought to be a proinflammatory cytokine, and LVH, though such a relationship has not yet been explored in the literature.…”

Section: Introductionmentioning

confidence: 99%

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The Relationship of Visfatin Levels to Inflammatory Cytokines and Left Ventricular Hypertrophy in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

Erten

Ebinç

et al. 2008

Renal Failure

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Visfatin was recently defined as an adipocytokine; however, the pathophysiological role of visfatin is not completely understood. A few studies suggest that visfatin may be a new proinflammatory adipocytokine. The aim of the present study was to compare serum visfatin levels between hemodialysis and continuous ambulatory peritoneal dialysis (CAPD) patients and evaluate the relationship between visfatin levels to IL-6, TNF-α, and left ventricular hypertrophy. Serum visfatin, IL-6, and TNF-α levels were measured by using the ELISA method, and echocardiographic evaluations were performed in 31 hemodialysis patients, 30 CAPD patients, and 21 healthy volunteers. Serum visfatin levels were higher in the CAPD group (265.27 ± 387.86 ng/mL) than hemodialysis (97.68 ± 244.96 ng/mL,) and control (41.33 ± 48.87 ng/mL) groups (p = 0.04, p = 0.01, respectively). No significant difference was observed between the hemodialysis and control groups. In univariate analysis, visfatin levels were positively correlated with IL-6 (r = 0.24, p = 0.03), TNF-α (r = 0.34, p = 0.002), and BMI (r = 0.26, p = 0.03) and negatively correlated with some left ventricular diastolic parameters [Em and Em/Am (r = −0.305, p = 0.01), (r = −0.251, p = 0.03), respectively]. No relationship was found between visfatin and left ventricular mass index. In the linear regression analysis, visfatin levels independently related with TNF-( (β = 0.369, p = 0.001) and p = 0.015). This study has found significantly higher levels of serum visfatin in CAPD patients when compared to healthy individuals. Increased visfatin levels seem to associate with proinflammatory cytokines such as IL-6 or TNF-α. As for the effects of on left ventricular structure and functions, visfatin might have negative effects on left ventricular diastolic function parameters but have no effects on left ventricular mass index.

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Section: Introductionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Relationship of Visfatin Levels to Inflammatory Cytokines and Left Ventricular Hypertrophy in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

Erten

Ebinç

et al. 2008

Renal Failure

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“…Furthermore, NAMPT was found to be predominantly produced and released by the adipose tissue-derived macrophages [28]. The reported association between NAMPT and inflammatory markers raises the possibility of inflammatory properties of NAMPT [29][30][31][32]. NAMPT has been shown to upregulate IL-6, IL1b and tumour necrosis factor (TNF) a in human monocytes [30].…”

Section: Introductionmentioning

confidence: 99%

Association of increased Visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity

Catalán

Gómez-Ambrosi

Rodríguez

et al. 2010

Nutrition, Metabolism and Cardiovascular Diseases

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Background and aims: Nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine with physiological effects on the control of glucose homeostasis as well as potentially involved in inflammation. The association of circulating NAMPT concentrations with obesity has not been clearly established. The aim of the present work was to evaluate the effect of obesity on circulating concentrations and gene expression levels of NAMPT in human peripheral blood cells (PBCs) as well as its involvement in inflammation, glucose and lipid metabolism.

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Visfatin in overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: a meta‐analysis and systemic review

Chang

Lin

et al. 2011

Diabetes Metabolism Res

309

217

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There are controversies regarding the association of visfatin with overweight/obesity, type 2 diabetes mellitus, insulin resistance (IR), metabolic syndrome and cardiovascular disease in published articles. A meta-analysis was performed to identify the significance of visfatin in these diseases. We searched for relevant articles in Pubmed, Scopus and SCIE. A total of 1035 articles were surveyed and 46 articles were identified, with 14 reports reporting more than one of our investigated diseases. A total of 13 (n = 644), 19 (n = 2405), 20 (n = 2249), 5 (n = 527) and 5 (n = 851) articles/(participants) were included in each meta-analysis regarding the association of visfatin and overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases, respectively. Plasma visfatin concentrations were increased in participants diagnosed with overweight/obesity, type 2 diabetes mellitus, metabolic syndrome and cardiovascular diseases, with pooled log odds ratios of 1.164 [95% confidence interval (CI): 0.348 to 1.981, p = 0.005], 1.981 (95% CI: 1.377 to 2.584, p< 0.001), 1.094 (95% CI: 0.678 to 1.511, p < 0.001), and 2.902 (95% CI: 0.924 to 4.879, p < 0.005), respectively. The circulating visfatin level was positively associated with insulin resistance, with a Fisher's z of 0.089 (95% CI: 0.013 to 0.165, p = 0.022). No single study was found to affect the overall result of each analysis by sensitivity testing. No publication bias was found by the Egger test. Our study suggests that the use of visfatin may be promising for predicting obesity, diabetes status, insulin resistance, metabolic syndrome and cardiovascular disease.

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Plasma visfatin levels are positively associated with circulating interleukin-6 in apparently healthy Korean women

Cited by 33 publications

References 17 publications

The Relationship of Visfatin Levels to Inflammatory Cytokines and Left Ventricular Hypertrophy in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

The Relationship of Visfatin Levels to Inflammatory Cytokines and Left Ventricular Hypertrophy in Hemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

Association of increased Visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity

Visfatin in overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: a meta‐analysis and systemic review

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