Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosus

Abstract

Plasma adiponectin levels are increased in patients with renal SLE compared to healthy controls and patients with nonrenal SLE. During renal but not nonrenal SLE flare, urine adiponectin levels increase significantly. Urine adiponectin may be a biomarker of renal SLE flare.

Predictive Value of Serum and Urinary Adiponectin in Systemic Lupus Erythematosus Activity and Lupus Nephritis

“…In our study, there was significantly higher serum adiponectin level among SLE patients with LN compared to SLE patients without LN, this is in agreement with Rovin et al study in 2005 27 , who demonstrated that plasma adiponectin levels are increased in patients with renal SLE compared to healthy controls and patients with non renal SLE.…”

“…Our study showed significantly higher urinary adiponectin level in SLE patients when compared to controls and significantly higher urinary adiponectin level among SLE patients with LN when compared to patients without LN, this is concided with Rovin et al study in 2005 27 , who stated that urine adiponectin levels increased significantly with renal flare, but not non renal SLE flare.…”

Podocyte-specific Expression of C1q/TNF-α Related Protein 1 in Mice

“…A recent report showed that CTRP1 prevents collagen-induced platelet aggregation by specifically blocking von Willebrand's factor (vVW) binding to collagen [8]. In this study, we showed that CTRP1 is expressed in podocytes but not in endothelial cells or smooth muscle cells of the intrarenal arteries/arterioles, or in the endothelium of the glomerular and peritubular capillaries in the normal kidney [2]. In addition, CTRP1 expression is attenuated in the podocytes of an animal model of glomerulosclerosis.…”

Adipocytokines as driving forces in rheumatoid arthritis and related inflammatory diseases?

“…Plasma and urine adiponectin levels appear to be increased in patients with SLE, especially in those with inflammatory glomerulonephritis (61). Interestingly, full-length (containing all isoforms) but not globular adiponectin induced IL-8 and monocyte chemoattractant protein 1 in microvascular endothelial cells and monocytes (62).…”